Candidate gene approach in genetic epidemiological studies of osteoarthritis-related pain

Bratuś, Anna; Aeschlimann, André; Russo, Giancarlo; Sprott, Haiko

doi:10.1016/j.pain.2013.07.031

Cited by 8 publications

(8 citation statements)

References 37 publications

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“…The presumed correlations between the covariates were visualized in diagrams based on existing literature within the field () (see Supplementary Figure 1 and 2, available in the online version of this article at http://onlinelibrary.wiley.com/doi/10.1002/acr.22460/abstract). We proposed different models ranging from simple (assuming correlation only between a few variables) to more complex models (assuming correlation between several covariates).…”

Section: Methodsmentioning

confidence: 99%

“…Slatkowsky‐Christensen et al showed that persons with symptomatic hand OA experience fibromyalgia‐like symptoms (). Knee OA studies have shown that depression, high body mass index (BMI), low socioeconomic status, and hereditary factors are associated with knee pain (). Whether these relationships also exist in persons with hand OA is unknown because of the lack of studies.…”

Section: Introductionmentioning

confidence: 99%

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Diabetes Is Associated With Increased Hand Pain in Erosive Hand Osteoarthritis: Data From a Population‐Based Study

Magnusson

Hagen

Østerås

et al. 2015

Arthritis Care & Research

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diabetes Is Associated With Increased Hand Pain in Erosive Hand Osteoarthritis: Data From a Population‐Based Study

Magnusson

Hagen

Østerås

et al. 2015

Arthritis Care & Research

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“…The increasing role of genetics in the pathogenesis of OA has been highlighted by epidemiological studies of family history and clustering, adoption studies, twin studies, and exploration of rare genetic disorders related to OA (Valdes and Spector, 2009). Several genome-wide association studies (Kerkhof et al, 2010;Zeggini et al, 2012;Pang et al, 2013) and candidate gene studies (Bratus et al, 2013;Gonzalez, 2013;Reynard and Loughlin, 2013) have suggested that polymorphisms in certain genes affects the pathogenesis of OA.…”

Section: Introductionmentioning

confidence: 99%

Effect of RAGE polymorphisms on susceptibility to and severity of osteoarthritis in a Han Chinese population: a case-control study

Yang¹,

Chuang²,

Fang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Recent studies have revealed that the inflammatory process plays a role in the pathogenesis of osteoarthritis (OA). The S100 family and receptor for advanced glycation end products (RAGE) 11363 RAGE gene in osteoarthritis ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 11362-11370 (2015) participate in regulating inflammation, even in the production of matrix metalloproteinases (MMPs). MMP-1 degrades cartilage, which may result in OA development. Moreover, polymorphisms in RAGE, S100A8, and MMP-1 have a marked effect on ligand binding and transcription regulating. In this study, we investigated the potential genetic contribution of the RAGE, S100A8, and MMP-1 genes to OA. We performed a matched case-control association study and genotyped OA patients and healthy controls, who were analyzed by polymerase chain reaction-restriction fragment length polymorphism assays. A total of 207 patients were diagnosed with knee OA and underwent total knee replacement. The control group included 207 individuals who had standard X-rays of the knee joints to confirm K/L < 2 and were matched by age and gender. Single-nucleotide polymorphisms in RAGE (-429T/C, -374T/A, and 557G/A), S100A8 (rs3795391A/G), and MMP-1 (-1607 1G/2G, -755G/T, and -519A/G) were evaluated. RAGE -374T/A, S100A8 rs3795391A/G, MMP-1 -1607 1G/2G, -755G/T, and -519A/G showed no significant difference between OA patients and healthy controls. RAGE -429T/C and 557G/A showed a significant association between OA patients and healthy controls (P = 0.016 and 0.047, respectively). In haplotype analyses, no RAGE and MMP-1 haplotypes showed associations with OA. Our results suggest that the investigated polymorphism in the RAGE gene play a role in OA in the Han Chinese population.

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“…A possible explanation could be the differences in the pain perception pathways of the two groups. Of note, polymorphisms in COMT and TRPV1 genes have recently been identified which could alter the processing of nociceptive pain associated with OA [ 29 ]. Another possible explanation could be that meniscal pathology in the offspring is morphologically different but this could not be differentiated on MRI.…”

Section: Discussionmentioning

confidence: 99%

Natural history and clinical significance of meniscal tears over 8 years in a midlife cohort

Khan

Aitken

Ding

et al. 2016

BMC Musculoskelet Disord

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BackgroundThere is limited longitudinal data available on the natural history of meniscal tears especially in middle-aged adults with a low prevalence of osteoarthritis (OA). The aim of this study was to describe the natural history of meniscal tears over 8 years and the relationship with change in knee pain and structures.MethodsOne hundred ninety eight participants [mean age 47 (28–63); 57 % female] were studied at baseline and 8 years later. Approximately half were the adult offspring of subjects who had a knee replacement performed for knee OA and the remainder were randomly selected controls. Meniscal tears/extrusion, cartilage volume/defects, bone marrow lesions (BMLs) and effusion were assessed on MRI. Knee pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index.Results22 % of the participants had at least one meniscal tear at any site at baseline. Over 8 years, 16 % of the participants had an increase in severity of meniscal tears while none improved. Increase in meniscal tear score was associated with worsening knee pain (β = +2.81 (+1.40, +4.22)), with offspring having a significantly greater increase in pain severity compared to controls. BMI and presence of osteophytes at baseline, but not knee injury, predicted change in tears, whereas change in meniscal tears was independently associated with cartilage volume loss, change in BMLs and change in meniscal extrusion.ConclusionChange in meniscal tears shares risk factors with knee OA and is independently associated with worsening knee pain and structural damage suggesting that meniscal tears are on the knee OA causal pathway.

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Candidate gene approach in genetic epidemiological studies of osteoarthritis-related pain

Cited by 8 publications

References 37 publications

Diabetes Is Associated With Increased Hand Pain in Erosive Hand Osteoarthritis: Data From a Population‐Based Study

Diabetes Is Associated With Increased Hand Pain in Erosive Hand Osteoarthritis: Data From a Population‐Based Study

Effect of RAGE polymorphisms on susceptibility to and severity of osteoarthritis in a Han Chinese population: a case-control study

Natural history and clinical significance of meniscal tears over 8 years in a midlife cohort

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