Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF

Valente, Nina Leão Marques; Vallada, Homero; Cordeiro, Quirino; Miguita, Karen; Bressan, Rodrigo A.; Andreoli, Sérgio Baxter; Mari, Jair J.; Mello, Marcelo Feijó de

doi:10.1007/s12031-011-9513-7

Cited by 74 publications

(68 citation statements)

References 64 publications

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“…There are several studies with controversial results of BDNF rs6265 in association with PTSD susceptibility [25] [29]. Our study showed the involvement of BDNF rs6265 in PTSD.…”

Section: Discussionsupporting

confidence: 57%

Genetic Polymorphisms of Nervous System Development and the Risk of Posttraumatic Stress Disorder

Avetyan¹,

Arakelyan²,

Mkrtchyan³

2018

AJMB

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Background: Posttraumatic stress disorder (PTSD) is a complex severe polygenic psychiatric disease, influenced by environmental and genetic factors. PTSD development and progression is characterized by cognitive impairment, which may result in altered processes of nervous system development and synaptic plasticity, where a number of growth factors and their receptors were shown to play important role. Since neurotrophins play an essential role in the development of central nervous system, it is widely implicated in psychiatric disorders. The aim of this study is to investigate the potential association functional polymorphisms of genes encoding netrin G1 (NTNG1), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and its receptor (NGFR) with PTSD. Methods: Study groups consisted of 200 combat veterans with PTSD and an equal number of controls with no family or past history of any psychiatric disorders. The DNA samples were genotyped for NTNG1 rs62811; BDNF rs6265; NGF rs6330, rs4839435; NGFR rs11466155, rs734194 SNPs using polymerase chain reaction with sequence specific primers. Results: According to the results, NGF rs6330 was overrepresented in patients with PTSD compared to controls. Furthermore, negative association for BDNF rs6265, NGF rs4839435 and NGFR rs734194 was observed in PTSD patients. Conclusions: In summary, BDNF rs6265, NGF rs6330, rs4839435 and NGFR rs734194 are implicated in PTSD in Armenian population. However, further research is required to provide the definitive evidence of selected polymorphism association with gene expression.

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“…There are several studies with controversial results of BDNF rs6265 in association with PTSD susceptibility [25] [29]. Our study showed the involvement of BDNF rs6265 in PTSD.…”

Section: Discussionsupporting

confidence: 57%

Genetic Polymorphisms of Nervous System Development and the Risk of Posttraumatic Stress Disorder

Avetyan¹,

Arakelyan²,

Mkrtchyan³

2018

AJMB

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“…In one study, low BDNF serum levels were associated with PTSD, while another reported no relationship to PTSD in victims of urban violence (Valente et al. 2011). However, the Met allele (one and two alleles) of BDNF Val66Met polymorphism may be associated with PTSD severity in veterans (Pivac et al.…”

Section: Introductionmentioning

confidence: 99%

Brain‐derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress

et al. 2015

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BackgroundIn addition to experiencing traumatic events while deployed in a combat environment, there are other factors that contribute to the development of posttraumatic stress disorder (PTSD) in military service members. This study explored the contribution of genetics, childhood environment, prior trauma, psychological, cognitive, and deployment factors to the development of traumatic stress following deployment.MethodsBoth pre‐ and postdeployment data on 231 of 458 soldiers were analyzed. Postdeployment assessments occurred within 30 days from returning stateside and included a battery of psychological health, medical history, and demographic questionnaires; neurocognitive tests; and blood serum for the D2 dopamine receptor (DRD2), apolipoprotein E (APOE), and brain‐derived neurotropic factor (BDNF) genes.ResultsSoldiers who screened positive for traumatic stress at postdeployment had significantly higher scores in depression (d = 1.91), anxiety (d = 1.61), poor sleep quality (d = 0.92), postconcussion symptoms (d = 2.21), alcohol use (d = 0.63), traumatic life events (d = 0.42), and combat exposure (d = 0.91). BDNF Val66 Met genotype was significantly associated with risk for sustaining a mild traumatic brain injury (mTBI) and screening positive for traumatic stress. Predeployment traumatic stress, greater combat exposure and sustaining an mTBI while deployed, and the BDNF Met/Met genotype accounted for 22% of the variance of postdeployment PTSD scores (R 2 = 0.22, P < 0.001). However, predeployment traumatic stress, alone, accounted for 17% of the postdeployment PTSD scores.ConclusionThese findings suggest predeployment traumatic stress, genetic, and environmental factors have unique contributions to the development of combat‐related traumatic stress in military service members.

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“…During each stage of screening, the literature articles were clearly identified and a consensus could be established. Finally, 6 articles [14,16,17,18,19,26] were selected. Articles in each selection step are shown in online supplementary figure S1.…”

Section: Resultsmentioning

confidence: 99%

“…The related studies were conducted in adults among European (Croatia), Asian (South Korea) and American populations (USA and Brazil). In detail, 3 articles [16,19,26] involved healthy individuals as controls, and another 2 papers [14,17] used people who suffered from the same stress as cases but without PTSD symptoms - 1 article [18 ]contained both types of controls and thus were treated separately as 2 studies. In addition, 2 articles [14,17] examined PTSD participants who were exposed to stress/traumatic events from active duty in the army.…”

Section: Resultsmentioning

confidence: 99%

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Does<b><i> BDNF</i></b> Val66Met Polymorphism Confer Risk for Posttraumatic Stress Disorder?

Wang¹

2015

Neuropsychobiology

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Background: Evidence has indicated that BDNF (brain-derived neurotrophic factor) Val66Met genetic variant could be linked to the development of posttraumatic stress disorder (PTSD). However, clinical observations studying the BDNF polymorphism and the risk of PTSD yielded contradictory results. In this meta-analysis we evaluated the association between BDNF Val66Met and PTSD risk. Method: Systematic searches in online databases retrieved 6 relevant publications. Different inherited models were utilized to perform the pooled analysis. Subgroup analyses and sensitive analyses based on Hardy-Weinberg equilibrium (HWE) test results were also carried out. Results: Our study did not found a significant overall effect of BDNF Val66Met on the susceptibility to PTSD under various genetic models. In contrast, subgroup analyses suggested that the stress status of the control group, but not ethnicity, may influence the relationship of BDNF Val66Met with PTSD risk. After the exclusion of a study that was not in HWE, our conclusions remained unchanged during the influence analyses. Conclusions: This meta-analysis suggested no genetic association of BDNF Val66Met with vulnerability to PTSD. Further research studies are warranted to clarify the impact of BDNF variants on the occurrence of PTSD.

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Candidate-Gene Approach in Posttraumatic Stress Disorder After Urban Violence: Association Analysis of the Genes Encoding Serotonin Transporter, Dopamine Transporter, and BDNF

Cited by 74 publications

References 64 publications

Genetic Polymorphisms of Nervous System Development and the Risk of Posttraumatic Stress Disorder

Genetic Polymorphisms of Nervous System Development and the Risk of Posttraumatic Stress Disorder

Brain‐derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress

Does<b><i> BDNF</i></b> Val66Met Polymorphism Confer Risk for Posttraumatic Stress Disorder?

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