Candidate Gene Region 15q26 and Genetic Susceptibility to Coeliac Disease in Finnish Families

Abstract

The 15q26 region appears not to be a major non-HLA susceptibility locus for gluten sensitivity in Finland, but a particular haplotype which may harbour a susceptibility gene was identified.

Genome screening of coeliac disease

“…The putative candidate loci detected in the three studies are, however, largely inconsistent and the findings have not been replicated in other populations. [15][16][17][18][19] Here we report the results of a genome screen of 24 multiplex families with coeliac disease and discuss the findings of this study in relation to previously published analyses.…”

Dexamethasone-induced selenoprotein S degradation is required for adipogenesis

“…( 44 ). Genetic variations of human SEPS1 located on chromosome 15q26.3, which was suggested to contain quantitative trait loci infl uencing infl ammation-related disorders such as type 2 diabetes, Alzheimer's disease, and celiac disease (45)(46)(47), were reported to be strongly associated with infl ammation in Mexican American individuals ( 13 ). Recently, variation in the SEPS1 gene locus has been reported to be associated with coronary heart disease ( 48 ), preeclampsia ( 49 ), gastric cancer ( 50 ), non-small cell lung cancer ( 51 ), and aggressive periodontitis ( 52 ).…”

A new locus for coeliac disease mapped to chromosome 15 in a population isolate

“…Our genome-wide scan in 60 Finnish coeliac families from the general population, which did not overlap with the present set of families implicated a region on chromosome 5q31 as well; however the strongest evidence was for linkage to 4p15 (Liu et al 2002). Replication studies in the Finnish population have also given some evidence for linkage to 5qter and 11q , but not to 15q26 (Susi et al 2001). Linkage to the CTLA-4/CD28 gene region has been shown in several populations in candidate gene studies (Djilali-Saiah et al 1998;Naluai et al 2000;King et al 2002) including the Finns (Holopainen et al 1999), even though this region has not been implicated in the genomewide scans.…”