Candidate Genes Involved in Beneficial or Adverse Responses to Commonly Eaten Brassica Vegetables in a New Zealand Crohn’s Disease Cohort

Abstract

Crohn’s disease (CD) is one of the two manifestations of inflammatory bowel disease. Particular foods are thought with CD to exacerbate their illness. Vegetables, especially Brassicaceae, are often shunned by people with CD because of the negative effects they are alleged to have on their symptoms. Brassicaceae supply key nutrients which are necessary to meet recommended daily intakes. We sought to identify the candidate genes involved in the beneficial or adverse effects of Brassicaceae most commonly eaten, as reported by the New Zealand adults from the “Genes and Diet in Inflammatory Bowel disease Study” based in Auckland. An analysis of associations between the single nucleotide polymorphisms (SNPs) and the beneficial or adverse effects of the ten most commonly eaten Brassicaceae was carried out. A total of 37 SNPs were significantly associated with beneficial effects (p = 0.00097 to 0.0497) and 64 SNPs were identified with adverse effects (p = 0.0000751 to 0.049). After correcting for multiple testing, rs7515322 (DIO1) and rs9469220 (HLA) remained significant. Our findings show that the tolerance of some varieties of Brassicaceae may be shown by analysis of a person’s genotype.

Evaluation of diet pattern related to the symptoms of mexican patients with Ulcerative Colitis (UC): through the validity of a questionnaire

“…Another group of foods that caused symptoms in patients with UC were the cruciferous and dairy in Group C (yogurt, skimmed milk, orange, papaya, watermelon, coffee, fried potato chips, cream, lactose-free mil, baked potato and cucumber). This effect may be related to the findings from Laing et al who showed that genetic polymorphisms in DIO1 (Hormonal Regulation Peroxidase) and HLA (which regulate the activity of the IL1 and IL6) causes poor absorption of crucifers, overpopulation of E. Coli and increased inflammation in IBD patients [ 19 ]. Dairy products tend to result in a rate of sensitivity in patients with IBD ranging from 10 to 20% especially in those patients with inflammation in the terminal ileum.…”

A Personalised Dietary Approach—A Way Forward to Manage Nutrient Deficiency, Effects of the Western Diet, and Food Intolerances in Inflammatory Bowel Disease

“…This physiological reaction is the rationale for using the FODMAP dietary regime in gastrointestinal disorders like IBD [111,195]. This is based on studies with irritable bowel syndrome (IBS), where the decreased consumption of these fermentable carbohydrates has decreased abdominal symptoms (i.e., pain, flatulence, bloating, constipation, diarrhoea).…”

Nutritional Modulation of Gene Expression: Might This be of Benefit to Individuals with Crohn’s Disease?

“…Irrespective of nutrient composition, it has repeatedly been observed that foods considered to be beneficial for some individuals may actually cause adverse effects in others ( 11 , 22 ). Individuals with the diseases differ in genetic, epigenetic, and phenotypic characteristics, so it is not surprising that a single approach is unlikely to be beneficial to all.…”

“…While these chemicals have a range of effects generally considered to be beneficial in the population at large, this group of food plants also polarizes individuals with CD. Laing and coworkers associated SNPs and the beneficial or adverse effects of the 10 most commonly eaten foods in this group ( 22 ). One of the SNPs that showed exceptionally beneficial properties to individuals consuming cruciferous vegetables was in the defensin (DEFA6) gene.…”