Candidate Genes Involved in the Expression of Psychotic Symptoms: A Focus on Hallucinations

Sanjuán, Julio; Moltó, María Dolores; Tolosa, A.

doi:10.1007/978-1-4614-4121-2_13

Cited by 2 publications

(2 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An RDoC approach would also require an attempt to explain AH at the molecular, genetic level of analysis. However, as stated by Sanjuan et al ( 2013 ), “ although a large number of studies have examined the influence of environmental risk factors…for hallucinations…the molecular genetic predispositions has received little attention” (p. 235). This also holds for a dimensional approach to hallucinations, in that no molecular study exists of the genetic basis for “hearing voices” in non-psychotic individuals.…”

Section: Concluding Remarks Future Directions—vertical Synergymentioning

confidence: 99%

A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework

Badcock

Hugdahl

2014

Front. Hum. Neurosci.

View full text Add to dashboard Cite

The National Institute of Mental Health initiative called the Research Domain Criteria (RDoC) project aims to provide a new approach to understanding mental illness grounded in the fundamental domains of human behavior and psychological functioning. To this end the RDoC framework encourages researchers and clinicians to think outside the [diagnostic] box, by studying symptoms, behaviors or biomarkers that cut across traditional mental illness categories. In this article we examine and discuss how the RDoC framework can improve our understanding of psychopathology by zeroing in on hallucinations- now widely recognized as a symptom that occurs in a range of clinical and non-clinical groups. We focus on a single domain of functioning—namely cognitive [inhibitory] control—and assimilate key findings structured around the basic RDoC “units of analysis,” which span the range from observable behavior to molecular genetics. Our synthesis and critique of the literature provides a deeper understanding of the mechanisms involved in the emergence of auditory hallucinations, linked to the individual dynamics of inhibitory development before and after puberty; favors separate developmental trajectories for clinical and non-clinical hallucinations; yields new insights into co-occurring emotional and behavioral problems; and suggests some novel avenues for treatment.

show abstract

Section: Concluding Remarks Future Directions—vertical Synergymentioning

confidence: 99%

A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework

Badcock

Hugdahl

2014

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…This observation has led to the suggestion of FOXP2 as a potential candidate gene for schizophrenia vulnerability. In addition, common genetic variations in FOXP2 have been proposed to contribute to the etiology of this disease (Sanjuan et al 2013). In a preliminary study, we found that the common FOXP2 rs2396753 single nucleotide polymorphism (SNP) might be involved in language disorder vulnerability, including thought disorders and auditory hallucinations in schizophrenia (Sanjuan et al 2006).…”

Section: Introductionmentioning

confidence: 99%

FOXP2 expression and gray matter density in the male brains of patients with schizophrenia

Sanjuán

Castro-Martínez

García-Martí

et al. 2020

Brain Imaging and Behavior

Self Cite

View full text Add to dashboard Cite

Common genetic variants of FOXP2 may contribute to schizophrenia vulnerability, but controversial results have been reported for this proposal. Here we evaluated the potential impact of the common FOXP2 rs2396753 polymorphism in schizophrenia. It was previously reported to be part of a risk haplotype for this disease and to have significant effects on gray matter concentration in the patients. We undertook the first examination into whether rs2396753 affects the brain expression of FOXP2 and a replication study of earlier neuroimaging findings of the influence of this genetic variant on brain structure. FOXP2 expression levels were measured in postmortem prefrontal cortex samples of 84 male subjects (48 patients and 36 controls) from the CIBERSAM Brain and the Stanley Foundation Array Collections. High-resolution anatomical magnetic resonance imaging was performed on 79 male subjects (61 patients, 18 controls) using optimized voxel-based morphometry. We found differences in FOXP2 expression and brain morphometry depending on the rs2396753, relating low FOXP2 mRNA levels with reduction of gray matter density. We detected an interaction between rs2396753 and the clinical groups, showing that heterozygous patients for this polymorphism have gray matter density decrease and low FOXP2 expression comparing with the heterozygous controls. This study shows the importance of independent replication of neuroimaging genetic studies of FOXP2 as a candidate gene in schizophrenia. Furthermore, our results suggest that the FOXP2 rs2396753 affects mRNA levels, thus providing new knowledge about its significance as a potential susceptibility polymorphism in schizophrenia.

show abstract

Candidate Genes Involved in the Expression of Psychotic Symptoms: A Focus on Hallucinations

Cited by 2 publications

References 125 publications

A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework

A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework

FOXP2 expression and gray matter density in the male brains of patients with schizophrenia

Contact Info

Product

Resources

About