Candidate genes underlying heritable differences in reproductive seasonality between wild and domestic rabbits

Carneiro, Miguel; Piorno, Vicente; Rubin, Carl-Johan; Alves, Joel M.; Ferrand, Nuno; Alves, Paulo C.; Andersson, Leif

doi:10.1111/age.12299

Cited by 16 publications

(20 citation statements)

References 48 publications

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“…It will be fascinating to see if similar but engineered mutations in the TSHR have similar effects in mammals. One analysis on the genetic basis of altered seasonality in rabbits picked out a number of candidate genes but TSHR was not one of them (Carneiro et al, 2015). Nevertheless, if subsequent tests in mammals should indicate a link between TSHR and domestication, then it would be of interest to see how this, in turn, might connect with the growing body of evidence that supports the NCCH.…”

Section: Current Status Of the Two Hypotheses In Light Of The Genomimentioning

confidence: 99%

Revisiting two hypotheses on the “domestication syndrome” in light of genomic data

Уилкинс¹

2017

Vestn. VOGiS

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Институт теоретической биологии берлинского университета им. Гумбольдта, берлин, Германия Доместицированные млекопитающие разных видов имеют общий набор физических и физиологических признаков, которых не было у их диких предков. Совокупность этих признаков, называемая «синдро мом одомашнивания», остается загадкой со времен Чарльза Дарвина, открывшего этот феномен. В на стоящее время существуют две общие гипотезы, объясняющие это явление, которые отчасти при менимы и к другим позвоночным, например рыбам и птицам. Одну из этих гипотез мы называем гипоте зой тиреоидных гормонов (THH), а другую -гипо тезой клеток нервного гребня (NCCH). Каждая из гипотез приводит к совершенно разным выводам на уровне генетики. Основываясь на анализе по следних данных геномных исследований, имеющих отношение к обсуждаемому вопросу, мы пришли к выводу, что более обоснованной выглядит гипотеза NCCH. Тем не менее ряд наблюдений, сделанных на курах, указывает на потенциально важную роль из мененного метаболизма тиреоидных гормонов для процесса одомашнивания. Кроме того, недав ние исследования указывают на возможность существо вания дополнительных факторов одомашнивания, оказывающих влияние на приручаемость и социаль ность и не учитываемых ни одной из рассматрива емых гипотез. Кратко обсуждаются задачи, направ ленные на выявление генетических основ «синдро ма одомашнивания» и особенностей поведения, специфичных для процесса одомашнивания млеко питающих.Ключевые слова: одомашнивание животных; «син дром одомашнивания»; Чарльз Дарвин; сравни тельная геномика; неотения; клетки нервного гребня; метаболизм тиреоидных гормонов. Domesticated mammals of many different species share a set of physical and physiological traits that are not displayed by any of their wild progenitors. This suite of traits, now termed the "domestication syndrome" (DS), has been a puzzle since Charles Darwin discovered it. Two general explanations of its basis have been proposed, which in principle, could also apply to other vertebrates, such as fish and birds, whose domesticated varieties show some of its elements. The two ideas are termed here, respectively, the thyroid hormone hypothesis or the THH, and the neural crest cell hypothesis, the NCCH. The two ideas make distinctly different genetic predictions. Here, the current relevant evidence from genomics is evaluated and it is concluded that the NCCH has more support. Nevertheless, one set of observations, from chickens, suggest a potentially important role of altered thyroid metabolism in domestication. in addition, recent studies indicate the possibility of additional genetic factors in domestication, affecting tameness and sociality, that may go beyond either hypothesis. The tasks that lie ahead to fully ascertain the genetic bases of the "domes tication syndrome" and the behaviors that characterize mammalian domestication are discussed briefly.

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Section: Current Status Of the Two Hypotheses In Light Of The Genomimentioning

confidence: 99%

Revisiting two hypotheses on the “domestication syndrome” in light of genomic data

Уилкинс¹

2017

Vestn. VOGiS

View full text Add to dashboard Cite

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“…Melatonin receptors reconcile an overabundance of intra‐integral effects reliant on the cellular ambiance (Marseglia et al., ). Melatonin effects consist of variations in intra‐integral cyclical nucleotides such as intra‐integral localization of steroid hormone receptors and directive of G protein signalling proteins (Carneiro et al., ; Teixeira‐Gomes et al., ). Melatonin receptors change day by day.…”

Section: Research Progress Of Melatonin In Animal Reproductionmentioning

confidence: 99%

“…Melatonin receptors join surplus of intraintegral effects reliant on the cellular ambiance (Papis et al, 2007;Reiter et al, 2015). These consequences consist of variations in intra-integral cyclical nucleotides, such as intra-integral localization of steroid hormone receptors and directive of G protein signalling proteins (Carneiro et al, 2015;Chuffa et al, 2015 andTeixeira-Gomes et al, 2015). The changes in melatonin receptor manifestation and changes in endogenous melatonin creation are revealed in day-to-day beat sleep syndromes.…”

Section: Characteristic Of Melatonin Receptorsmentioning

confidence: 99%

Research progress on the role of melatonin and its receptors in animal reproduction: A comprehensive review

Talpur

Chandio

Brohi

et al. 2018

Reprod Domestic Animals

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Melatonin and its receptors play a crucial role in the regulation of the animal reproductive process, primarily in follicular development. However, the role that melatonin performs in regulating hormones related with reproduction remains unclear. Melatonin and its receptors are present both in female and male animals' organs, such as ovaries, heart, brain and liver. Melatonin regulates ovarian actions and is a key mediator of reproductive actions. Melatonin has numerous effects on animal reproduction, such as protection of gametes and embryos, response to clock genes, immune-neuroendocrine, reconciliation of seasonal variations in immune function, and silence or blockage of genes. The growth ratio of reproductive illnesses in animals has raised a remarkable concern for the government, animal caretakers and farm managers. In order to resolve this challenging issue, it is very necessary to conduct state-of-the-art research on melatonin and its receptors because melatonin has considerable physiognomies. This review article presents a current contemporary research conducted by numerous researchers from the entire world on the role of melatonin and its receptors in animal reproduction, from the year 1985 to the year 2017. Furthermore, this review shows scientific research challenges related to melatonin receptors and their explanations based on the findings of 172 numerous research articles, and also represents significant proficiencies of melatonin in order to show enthusiastic study direction for animal reproduction researchers.

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“…In a study on regions targeted by selection during domestication of rabbits, SSTR1, NR3C1 and PRLR were identified within such regions (Carneiro et al, 2015). PRLR is also situated in a quantitative trait loci for growth in chickens (Kerje et al, 2003), and is differently expressed in the adrenal glands of tame and aggressive foxes (Hekman, 2017).…”

Section: The Pituitary Gland As a Regulator Of Domestication-related mentioning

confidence: 99%

Domestication and early experiences in chickens: Behavior, stress and gene expression

Løtvedt¹

2017

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A number of animal species have undergone domestication, the process of becoming adapted to living in captivity and in proximity to humans. Common for these species is that they have all developed certain traits, including changes to coat color, body size and level of fearfulness. This has been termed the domestic phenotype. Among these traits is also an attenuation of the response to stress, both behaviorally and physiologically. Thus, release of glucocorticoids such as cortisol or corticosterone is lower in domesticated species. However, the underlying mechanism for this is not yet well understood. In this thesis, we have investigated genetic mechanisms for the attenuation of the physiological stress response in ancestral chickens, the Red Junglefowl, and domesticated chickens, the White Leghorn.We found a number of genes that differed in expression between the two breeds in several tissues involved in the stress response. Among the most interesting findings were lower expression of genes involved in production and secretion of ACTH in the pituitary, and in the production of glucocorticoids in the adrenal glands, in the domesticated White Leghorns. We also found higher expression of the glucocorticoid receptor in White Leghorns, indicating that they may have a more efficient negative feedback of the physiological stress response.We then investigated the transcriptome of the chicken pituitary more closely, and we discovered that a number of genes highly involved in several important physiological axes showed differential expression between the ancestral and the domesticated breed. Among these were genes involved in the stress response, the reproductive system, and in metabolism and growth. As these traits are modified in domesticated species, our results suggest that changes to gene expression in the pituitary may be an important underlying factor of the domestic phenotype.A separate aim of this thesis was to investigate effects of hatching time in chickens on their subsequent phenotype. Time of hatching constitutes an early experience that may differ between individuals, and we therefore hypothesized that differences in hatching time would affect chickens later in life. While a number of studies have been performed on hatching time and post-hatch growth, very little work has been done on effects on behavior. We found that the time of hatching had sex-specific effects. Hatching times in females were negatively correlated with body weight, whereas in males, behaviors such as reaction to novelty and spatial learning were affected.As time of hatching is governed by various hormones, including thyroid hormone and corticosterone, we suggest that changes to the levels of these hormones could affect both hatching time and post-hatch phenotypes. Understanding these mechanisms better would be beneficial in terms of production, where batch homogeneity is important, in research on early experiences and the potential for maternal programming, and in evolutionary questions on trade-off between different life strateg...

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Candidate genes underlying heritable differences in reproductive seasonality between wild and domestic rabbits

Cited by 16 publications

References 48 publications

Revisiting two hypotheses on the “domestication syndrome” in light of genomic data

Revisiting two hypotheses on the “domestication syndrome” in light of genomic data

Research progress on the role of melatonin and its receptors in animal reproduction: A comprehensive review

Domestication and early experiences in chickens: Behavior, stress and gene expression

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