Candidate new rotavirus species in Schreiber's bats, Serbia

Bányai, Krisztiàn; Kemenesi, Gábor; Budinski, İvana; Földes, Fanni; Zana, Brigitta; Marton, Szilvia; Varga-Kugler, Renáta; Oldal, Miklós; Kurucz, Kornélia; Jakab, Ferenc

doi:10.1016/j.meegid.2016.12.002

Cited by 175 publications

(169 citation statements)

References 27 publications

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“…For example, bats are hosts of rotaviruses, and some strains of rotavirus are genetically related to other mammalian rotaviruses, although other strains are bat-specific 7,181 . The significance of bats as a reservoir for rotavirus transmission to other mammalian species (including humans) remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Rotavirus infection

Crawford

Ramani

Tate

et al. 2017

Nat Rev Dis Primers

554

558

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Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in >200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system. In addition, rotavirus infections can lead to antigenaemia (which is associated with more severe manifestations of acute gastroenteritis) and viraemia, and rotavirus can replicate in systemic sites, although this is limited. Reinfections with rotavirus are common throughout life, although the disease severity is reduced with repeat infections. The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific immunoglobulin A has a role in both aspects. The management of rotavirus infection focuses on the prevention and treatment of dehydration, although the use of antiviral and anti-emetic drugs can be indicated in some cases.

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Section: Discussionmentioning

confidence: 99%

Rotavirus infection

Crawford

Ramani

Tate

et al. 2017

Nat Rev Dis Primers

554

558

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“…On the basis of antigenicity of VP6 protein, genus Rotavirus is classified into eight recognized species (RVA‐RVH) and two proposed species ( RVI and RVJ ), identified recently in sheltered dogs in Hungary and in bats in Serbia, respectively, although confirmation by the International Committee on Taxonomy of Viruses is pending . Among these, RVA to RVC, RVE, RVH, and RVI are known to infect mammals, and RVA is the most widespread species in most, if not all, mammalian hosts .…”

Section: Classification Of Rvmentioning

confidence: 99%

Rotavirus: Genetics, pathogenesis and vaccine advances

Sadiq

Bostan

Yinda

et al. 2018

Reviews in Medical Virology

103

110

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Since its discovery 40 years ago, rotavirus (RV) is considered to be a major cause of infant and childhood morbidity and mortality particularly in developing countries. Nearly every child in the world under 5 years of age is at the risk of RV infection. It is estimated that 90% of RV-associated mortalities occur in developing countries of Africa and Asia. Two live oral vaccines, RotaTeq (RV5, Merck) and Rotarix (RV1, GlaxoSmithKline) have been successfully deployed to scale down the disease burden in Europe and America, but they are less effective in Africa and Asia. In April 2009, the World Health Organization recommended the inclusion of RV vaccination in national immunization programs of all countries with great emphasis in developing countries. To date, 86 countries have included RV vaccines into their national immunization programs including 41 Global Alliance for Vaccines and Immunization eligible countries. The predominant RV genotypes circulating all over the world are G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8], while G12[P6] and G12[P8] are emerging genotypes. On account of the segmented genome, RV shows an enormous genetic diversity that leads to the evolution of new genotypes that can influence the efficacy of current vaccines. The current need is for a global RV surveillance program to monitor the prevalence and antigenic variability of new genotypes to formulate future vaccine development planning. In this review, we will summarize the previous and recent insights into RV structure, classification, and epidemiology and current status of RV vaccination around the globe and will also cover the status of RV research and vaccine policy in Pakistan.

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“…RVs are classified into 10 groups (A–J) based on antigenic relationships of their VP6 proteins, with provisional I and J species recently identified in sheltered dogs in Hungary and in bats in Serbia, respectively [9,10,11,12]. The outer capsid proteins, VP7 and VP4, induce neutralizing antibodies and form the basis for the G and P dual typing system [9].…”

Section: Introductionmentioning

confidence: 99%

Porcine Rotaviruses: Epidemiology, Immune Responses and Control Strategies

Vlasova

Amimo

Saif

2017

Viruses

188

197

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Rotaviruses (RVs) are a major cause of acute viral gastroenteritis in young animals and children worldwide. Immunocompetent adults of different species become resistant to clinical disease due to post-infection immunity, immune system maturation and gut physiological changes. Of the 9 RV genogroups (A–I), RV A, B, and C (RVA, RVB, and RVC, respectively) are associated with diarrhea in piglets. Although discovered decades ago, porcine genogroup E RVs (RVE) are uncommon and their pathogenesis is not studied well. The presence of porcine RV H (RVH), a newly defined distinct genogroup, was recently confirmed in diarrheic pigs in Japan, Brazil, and the US. The complex epidemiology, pathogenicity and high genetic diversity of porcine RVAs are widely recognized and well-studied. More recent data show a significant genetic diversity based on the VP7 gene analysis of RVB and C strains in pigs. In this review, we will summarize previous and recent research to provide insights on historic and current prevalence and genetic diversity of porcine RVs in different geographic regions and production systems. We will also provide a brief overview of immune responses to porcine RVs, available control strategies and zoonotic potential of different RV genotypes. An improved understanding of the above parameters may lead to the development of more optimal strategies to manage RV diarrheal disease in swine and humans.

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Candidate new rotavirus species in Schreiber's bats, Serbia

Cited by 175 publications

References 27 publications

Rotavirus infection

Rotavirus infection

Rotavirus: Genetics, pathogenesis and vaccine advances

Porcine Rotaviruses: Epidemiology, Immune Responses and Control Strategies

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