Candidemia (Blood Infection) and Other Candida Infections

Abstract

Where in my body can I get a Candida infection? Candida infection can happen in almost any part of your body. Usually it develops on mucous membranes (in the mouth, genitals, etc.) but the infection can also be in your bloodstream. When Candida is in your bloodstream, the condition is called Candidemia. Candida infection can spread from your bloodstream to other parts of your body (such as your eyes, kidney, liver, and brain). If this happens, it is called Invasive Candidemia. Who is higher risk of getting Candida infections? People who are healthy do not usually get Candidemia. Healthy people however, may get a Candida infection in their mouth (called thrush) from taking certain drugs such as inhaled corticosteroids used to treat asthma and COPD. You are at higher risk of developing Candidemia if you:

Non-Albicans Species: Main Actors of Candidemia? Seven-Year Experience From a Single Centre

“…Other risk factors determined for candidemia in the literature include corticosteroid administration, CVC use, abdominal surgery, severe burns, renal failure requiring dialysis, broad-spectrum antibiotic use and low birth weight in newborns (22). In our study, prior broad-spectrum antibiotic therapy (97.7%), CVC use (79.5%) and TPN therapy (50%) were found to be compatible with the literature (Table 1).…”

Understanding the pathogenesis of infectious diseases by single-cell RNA sequencing

“…Candidiasis and aspergillosis account for a large proportion of these infections [ 75 ]. Candidiasis is caused by Candida , an opportunistic fungus that colonizes the skin and mucosa, which can lead to bloodstream infections, known as candidemia [ 76 ]. Single cell transcriptomic analysis showed that Candida stimulation induced dramatic and differential gene expression within CD4 + T cells, NK cells, and monocytes, while the upregulation of the IFN I pathway was consistent across all cell types [ 77 ].…”

Retrospective analysis of fungemia among children in Anka General Hospital, Nigeria, from October 2018 to November 2021: a case series

“…Globally, there has been an upward trend in recent years of candidemia; thus, timely diagnosis is crucial for appropriate clinical management and prevention of mortality [ 1 ]. These infections contribute to substantial in-hospital morbidity and mortality and are associated with an increased financial burden [ 2 ]. Bloodstream infections (BSIs) with yeast present with non-specific clinical signs and symptoms, making them difficult to distinguish from other infectious causes.…”

“…In children, the risk factors for candidemia are different from adults [ 4 ] and include severe acute malnutrition (SAM; weight-for-height Z score <−3 or bilateral edema and/or mid-upper-arm-circumference <125 mm) [ 2 ], underlying hematological/oncological malignancies [ 5 ], admission to a neonatal or pediatric intensive care unit [ 1 ], presence of a central venous catheter and severe immunosuppression (i.e. human immunodeficiency virus/acquired immune deficiency syndrome) [ 6 ].…”