2018
DOI: 10.1111/myc.12792
|View full text |Cite
|
Sign up to set email alerts
|

Candidemia in children: Epidemiology, prevention and management

Abstract: Candidemia is the leading cause of invasive fungal infections in hospitalised children. The highest rates of candidemia have been recorded in neonates and infants <1 year of age. Candidemia is more frequent in neonates and young infants than in adults, and is associated with better clinical outcomes, but higher inpatient costs. Over the last 10 years, a declining trend has been noted in the incidence of paediatric candidemia in the US and elsewhere due to the hospital-wide implementation of central-line insert… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
37
2
1

Year Published

2019
2019
2024
2024

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 52 publications
(42 citation statements)
references
References 107 publications
2
37
2
1
Order By: Relevance
“…It may be due to the intersection of exposure and Candida infection. However, 60%‐70% of paediatric ICU patients with Candida bloodstream infection are colonised with the same Candida spp., indicating that some exposed groups will progress to candidaemia or have occurred but not been diagnosed.…”
Section: Discussionmentioning
confidence: 99%
“…It may be due to the intersection of exposure and Candida infection. However, 60%‐70% of paediatric ICU patients with Candida bloodstream infection are colonised with the same Candida spp., indicating that some exposed groups will progress to candidaemia or have occurred but not been diagnosed.…”
Section: Discussionmentioning
confidence: 99%
“…The widespread use of broad‐spectrum antibiotics may also account for the increase in candidaemia cases in recent years . However, premature birth, prolonged stay at the intensive care unit (ICU) and immaturity are the main predisposing factors in neonates and children …”
Section: Introductionmentioning
confidence: 99%
“…1 However, premature birth, prolonged stay at the intensive care unit (ICU) and immaturity are the main predisposing factors in neonates and children. [2][3][4][5][6] The epidemiology of candidaemia has changed in the last decades. 7 Although Candida albicans has been mainly responsible for the majority of hospital-acquired candidaemia cases, non-albicans Candida species, that is C. parapsilosis, C. glabrata, C. tropicalis, C. krusei and C. guilliermondii, currently constitute a large proportion of Candida-related infections.…”
Section: Introductionmentioning
confidence: 99%
“…The annual incidence rate of candidemia is estimated to be 3.88 per 100,000 inhabitants, while reported incidence rates range from 1.0 to 10.4 [4]. Moreover, candidemia is the leading cause of invasive fungal infections in hospitalized children, particularly those undergoing intensive chemotherapy for acute leukemia and heterologous stem cell transplantation [5]. There are approximately two hundreds of Candida species, but those most commonly associated with invasive disease in humans are C. albicans, C. tropicalis, C. parapsilosis, C. glabrata, C. krusei, and C. auris [6].…”
Section: Introductionmentioning
confidence: 99%