Candidiasis esofágica en pacientes inmunocompetentes: Estudio clínico e inmunológico

M, Claudia Cortés; R, Danny Oksenberg; S, Alejandro Afani; C, Carlos Stott; S, Ana María Madrid

doi:10.4067/s0034-98872004001100008

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…In addition, fungi genuses were also identified by microscopy and these included Aspergillus and Penicillium, which are considered the airborne allergenic fungi most significant and found to be associated with adverse effects on human and animal health [28] . Additionally, yeasts identified were C. krusei and C. glabrata, both of which have been associated with adverse health effects in individuals with compromised immune systems [13,29] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Microbial Load in Oropharyngeal Mucosa from Tannery Workers

Castellanos-Arévalo¹,

Castellanos-Arévalo²,

Camarena‐Pozos³

et al. 2015

Safety and Health at Work

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BackgroundAnimal skin provides an ideal medium for the propagation of microorganisms and it is used like raw material in the tannery and footware industry. The aim of this study was to evaluate and identify the microbial load in oropharyngeal mucosa of tannery employees.MethodsThe health risk was estimated based on the identification of microorganisms found in the oropharyngeal mucosa samples. The study was conducted in a tanners group and a control group. Samples were taken from oropharyngeal mucosa and inoculated on plates with selective medium. In the samples, bacteria were identified by 16S ribosomal DNA analysis and the yeasts through a presumptive method. In addition, the sensitivity of these microorganisms to antibiotics/antifungals was evaluated.ResultsThe identified bacteria belonged to the families Enterobacteriaceae, Pseudomonadaceae, Neisseriaceae, Alcaligenaceae, Moraxellaceae, and Xanthomonadaceae, of which some species are considered as pathogenic or opportunistic microorganisms; these bacteria were not present in the control group. Forty-two percent of bacteria identified in the tanners group are correlated with respiratory diseases. Yeasts were also identified, including the following species: Candida glabrata, Candida tropicalis, Candida albicans, and Candida krusei. Regarding the sensitivity test of bacteria identified in the tanners group, 90% showed sensitivity to piperacillin/tazobactam, 87% showed sensitivity to ticarcillin/clavulanic acid, 74% showed sensitivity to ampicillin/sulbactam, and 58% showed sensitivity to amoxicillin/clavulanic acid.ConclusionSeveral of the bacteria and yeast identified in the oropharyngeal mucosa of tanners have been correlated with infections in humans and have already been reported as airborne microorganisms in this working environment, representing a health risk for workers.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Microbial Load in Oropharyngeal Mucosa from Tannery Workers

Castellanos-Arévalo¹,

Castellanos-Arévalo²,

Camarena‐Pozos³

et al. 2015

Safety and Health at Work

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“…High myopia (HM), the most challenging type, is defined as a spherical refraction error of −6 spherical diopters (SDs) or more, or an axial length greater than 26 mm. From a physiological point, myopia is a refractive error in which, in a state of relaxed accommodation, light rays parallel to the eye with an origin greater than 6 m away focus anteriorly on the retina after passing through the eye's refractive system [1,2]. This disease is a common cause of vision loss, with uncorrected myopia the leading cause of vision impairment globally.…”

Section: Introductionmentioning

confidence: 99%

Next-Generation Sequencing Screening of 43 Families with Non-Syndromic Early-Onset High Myopia: A Clinical and Genetic Study

González-Iglesias¹,

López-Vázquez

Noval

et al. 2022

IJMS

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Early-onset high myopia (EoHM) is a disease that causes a spherical refraction error of ≥−6 diopters before 10 years of age, with potential multiple ocular complications. In this article, we report a clinical and genetic study of 43 families with EoHM recruited in our center. A complete ophthalmological evaluation was performed, and a sample of peripheral blood was obtained from proband and family members. DNA was analyzed using a customized next-generation sequencing panel that included 419 genes related to ophthalmological disorders with a suspected genetic cause, and genes related to EoHM pathogenesis. We detected pathogenic and likely pathogenic variants in 23.9% of the families and detected variants of unknown significance in 76.1%. Of these, 5.7% were found in genes related to non-syndromic EoHM, 48.6% in genes associated with inherited retinal dystrophies that can include a syndromic phenotype, and 45.7% in genes that are not directly related to EoHM or retinal dystrophy. We found no candidate genes in 23% of the patients, which suggests that further studies are needed. We propose a systematic genetic analysis for patients with EoHM because it helps with follow-up, prognosis and genetic counseling.

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