Canine Carpal Joint Fusion: A Model for Four-Corner Arthrodesis Using a Porous Tantalum Implant

Adams, Julie E.; Zobitz, Mark E.; Reach, John S.; An, Kai Nan; Lewallen, David G.; Steinmann, Scott P.

doi:10.1016/j.jhsa.2005.08.008

Cited by 17 publications

(7 citation statements)

References 33 publications

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“…Furthermore, this new material offers better osteoconduction than other technologies used for biological fixation. Although porous tantalum is in its early stages of evolution, the initial clinical data [ 135 , 136 , 137 , 138 ] and preclinical studies [ 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 ] support its use as an alternative to traditional orthopedic implant materials.…”

Section: Currently Used Metallic Scaffolds Materials and Their Limmentioning

confidence: 99%

Metallic Scaffolds for Bone Regeneration

2009

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Bone tissue engineering is an emerging interdisciplinary field in Science, combining expertise in medicine, material science and biomechanics. Hard tissue engineering research is focused mainly in two areas, osteo and dental clinical applications. There is a lot of exciting research being performed worldwide in developing novel scaffolds for tissue engineering. Although, nowadays the majority of the research effort is in the development of scaffolds for non-load bearing applications, primarily using soft natural or synthetic polymers or natural scaffolds for soft tissue engineering; metallic scaffolds aimed for hard tissue engineering have been also the subject of in vitro and in vivo research and industrial development. In this article, descriptions of the different manufacturing technologies available to fabricate metallic scaffolds and a compilation of the reported biocompatibility of the currently developed metallic scaffolds have been performed. Finally, we highlight the positive aspects and the remaining problems that will drive future research in metallic constructs aimed for the reconstruction and repair of bone.

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Section: Currently Used Metallic Scaffolds Materials and Their Limmentioning

confidence: 99%

Metallic Scaffolds for Bone Regeneration

2009

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“…Porous tantalum (trabecular metal) has been claimed to offer several advantages over other current conventional materials used for implants because of its uniformity and structural continuity, strength, low stiffness, high porosity, and high coefficient of friction 1–3. In preclinical studies, porous Ta constructs have been shown to provide excellent scaffolds for bone ingrowth and mechanical attachment3–9 and are now increasingly used for a variety of clinical applications 10–14. For example, porous tantalum uncemented acetabular cups have been used for revision total hip arthroplasty, with reported excellent bone apposition and incorporation and good short to medium term results 15.…”

Section: Introductionmentioning

confidence: 99%

Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype

Welldon

Atkins

Howie

et al. 2007

J Biomedical Materials Res

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Porous tantalum (Ta) has found application in orthopedics, although the interaction of human osteoblasts (HOB) with this material has not been reported. The aim of this study was to investigate the interaction of primary HOB with porous tantalum, using 5-mm thick discs of porous tantalum. Comparison was made with discs of solid tantalum and tissue culture plastic. Confocal microscopy was used to investigate the attachment and growth of cells on porous Ta, and showed that HOB attached successfully to the metal "trabeculae," underwent extensive cell division, and penetrated into the Ta pores. The maturation of HOB on porous Ta was determined in terms of cell expression of the osteoblast phenotypic markers, STRO-1, and alkaline phosphatase. Despite some donor-dependent variation in STRO-1/AlkPhos expression, growth of cells grown on porous Ta either promoted, or did not impede, the maturation of HOB. In addition, the expression of key osteoblastic genes was investigated after 14 days of culture. The relative levels of mRNA encoding osteocalcin, osteopontin and receptor activator of NFkappaB ligand (RANKL) was not different between porous or solid Ta or plastic, although these genes were expressed differently by cells of different donors. However, bone sialoprotein and type I collagen mRNA species showed a decreased expression on porous Ta compared with expression on plastic. No substrate-dependent differences were seen in the extent of in vitro mineralization by HOB. These results indicate that porous Ta is a good substrate for the attachment, growth, and differentiated function of HOB.

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“…After implanting TM acetabular cups in dogs, Bobyn et al (1999b) found bone ingrowth in all cups, indicating effective biological fixation. Using trabecular implants in carpal joint fusion in an animal study, Adams et al (2005) found early bone ingrowth and a substantial increase in the strength of the construct over time. Bouchard et al (2004) reported 1 case of successful use of TM as structural graft in a tarso-metatarsal arthrodesis.…”

Section: Discussionmentioning

confidence: 99%

Use of a trabecular metal implant in ankle arthrodesis after failed total ankle replacement

Henricson¹,

Rydholm²

2010

Acta Orthopaedica

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Background and purposeArthrodesis after failed total ankle replacement is complicated and delayed union, nonunion, and shortening of the leg often occur—especially with large bone defects. We investigated the use of a trabecular metal implant and a retrograde intramedullary nail to obtain fusion.Patients and methods13 patients with a migrated or loose total ankle implant underwent arthrodesis with the use of a retrograde intramedullary nail through a trabecular metal Tibial Cone. The mean follow-up time was 1.4 (0.6–3.4) years.ResultsAt the last examination, 7 patients were pain-free, while 5 had some residual pain but were satisfied with the procedure. 1 patient was dissatisfied and experienced pain and swelling when walking. The implant-bone interfaces showed no radiographic zones or gaps in any patient, indicating union.InterpretationThe method is a new way of simplifying and overcoming some of the problems of performing arthrodesis after failed total ankle replacement.

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Canine Carpal Joint Fusion: A Model for Four-Corner Arthrodesis Using a Porous Tantalum Implant

Cited by 17 publications

References 33 publications

Metallic Scaffolds for Bone Regeneration

Metallic Scaffolds for Bone Regeneration

Primary human osteoblasts grow into porous tantalum and maintain an osteoblastic phenotype

Use of a trabecular metal implant in ankle arthrodesis after failed total ankle replacement

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