Canine Coronavirus: Not Only an Enteric Pathogen

Decaro, Nicola; Buonavoglia, Canio

doi:10.1016/j.cvsm.2011.07.005

Cited by 80 publications

(81 citation statements)

References 45 publications

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“…Although our prevalence data are poorly informative about the impact of infection and disease in the populations, previous studies have shown that CCoV infection seems not to be frequently associated with fatal disease; instead, it often causes mild, self-limiting enteritis followed by rapid recovery [47]. Nevertheless, mortality may occur as a consequence of mixed infections with any of the two studied virus, CPV and/ or CDV [47,48].…”

Section: Canine Coronavirusmentioning

confidence: 87%

Unveiling patterns of viral pathogen infection in free-ranging carnivores of northern Portugal using a complementary methodological approach

Rosa

Santos

Grøndahl-Rosado

et al. 2020

Comparative Immunology, Microbiology and Infectious Diseases

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A B S T R A C TPathogen surveillance in free-ranging carnivores presents challenges due to their low densitie and secretive nature. We combined molecular and serological assays to investigate infections by viral pathogens (Canine parvovirus (CPV), Canine distemper virus (CDV) and Canine coronavirus (CCoV)) in Portuguese carnivores (Canis lupus, Vulpes vulpes, Lutra lutra, Martes foina, M. martes, Meles meles, and Genetta genetta) over a period of 16 years. Additionally we explored spatio-temporal patterns of virus occurrence in Canis lupus. Our study identified CPV DNA in all carnivore species with an overall prevalence of 91.9 %. CPV was detected in all sampled years and seasons in Canis lupus, supporting its enzootic nature. CDV RNA was mainly detected in the Canidae family, with viral nucleic acid recorded between 2005 and 2008 with a peak prevalence of 67 % among the wolf population, followed by a sharp decline, suggesting an epizootic behaviour of the virus. Antibodies show that mustelids and viverrids were often exposed to CDV. CCoV was first recorded by molecular methods in wolf samples in 2002, remaining in the wolf populations with marked fluctuations over time. The dual serological and molecular approach provided important epidemiological data on pathogens of wild carnivores in Portugal. These programmes should also include monitoring of other potential reservoir hosts such as domestic cats and dogs.

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Section: Canine Coronavirusmentioning

confidence: 87%

Unveiling patterns of viral pathogen infection in free-ranging carnivores of northern Portugal using a complementary methodological approach

Rosa

Santos

Grøndahl-Rosado

et al. 2020

Comparative Immunology, Microbiology and Infectious Diseases

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“…Canine viral enteritis is a major cause of death among dogs of very young age. The leading causes of canine viral enteritis include canine parvovirus 2, canine coronavirus and rotaviruses (Decaro and Buonavoglia, 2011;Osterhaus et al, 1980). More recent studies also attribute a role to caliciviruses and astroviruses (Castro et al, 2013;Martella et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Novel canine bocavirus strain associated with severe enteritis in a dog litter

Bodewes

Lapp²,

Hahn³

et al. 2014

Veterinary Microbiology

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Bocaviruses are small non-enveloped viruses with a linear ssDNA genome, that belong to the genus Bocaparvovirus of the subfamiliy Parvovirinae. Bocavirus infections are associated with a wide spectrum of disease in humans and various mammalian species. Here we describe a fatal enteritis associated with infection with a novel strain of canine bocavirus 2 (CaBoV-2), that occurred in a litter of German wirehaired pointers. Necropsy performed on three puppies revealed an enteritis reminiscent of canine parvovirus associated enteritis, accompanied with signs of lymphocytolytic disease in bone marrow, spleen, lymph nodes and thymus. While other major causes of enteritis of young dogs, including canine parvovirus, were excluded, by random PCR in combination with next-generation sequencing, a novel CaBoV-2 strain was detected. Phylogenetic analysis of the genome of this novel canine bocavirus strain indicated that this virus was indeed most closely related to group 2 canine bocaviruses. Infection with canine bocavirus was confirmed by in situ hybridization, which revealed the presence of CaBoV-2 nucleic acid in the intestinal tract and lymphoid tissues of the dogs. In a small-scale retrospective analysis concerning the role of CaBoV-2 no additional cases were identified. The findings of this study provide novel insights into the pathogenicity of canine bocaviruses.

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“…Fatal disease may occur as a consequence of mixed infections with CCoV together with CPV-2, Canine adenovirus type 1, or Canine distemper virus. 2,3 However, a hypervirulent variant, named pantropic CCoV, has been reported to cause fatal disease in infected dogs. 1,6,14 Canine coronavirus is an enveloped, singlestranded, positive-sense RNA virus belonging to the genus Alphacoronavirus (family Coronaviridae, subfamily Coronavirinae), species Alphacoronavirus 1, which also includes Feline coronavirus, Transmissible gastroenteritis virus (TGEV) of swine, and its derivative, Porcine respiratory coronavirus.…”

Section: 9mentioning

confidence: 99%

“…To date, 2 different genotypes of CCoV are known, I (CCoV-I) and II (CCoV-II). 2,3 Canine coronavirus type II is divided into 2 subtypes, IIa (classical strains) and IIb, with CCoV-IIb emerging as a result of a putative recombination between CCoV-IIa and TGEV. 13 Several studies have assessed the CPV and/or CCoV type distribution in different European countries, [6][7][8]13,18,20,21 but, to date, there is no epidemiological data about the circulation of these enteric pathogens in Albania.…”

Section: 9mentioning

confidence: 99%

Detection and genetic characterization of Canine parvovirus and Canine coronavirus strains circulating in district of Tirana in Albania

et al. 2014

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An epidemiological survey for Canine parvovirus 2 (CPV-2) and Canine coronavirus (CCoV) was conducted in Albania. A total of 57 fecal samples were collected from diarrheic dogs in the District of Tirana during 2011–2013. The molecular assays detected 53 and 31 CPV- and CCoV-positive specimens, respectively, with mixed CPV–CCoV infections diagnosed in 28 dogs. The most frequently detected CPV type was 2a, whereas IIa was the predominant CCoV subtype. A better comprehension of the CPV–CCoV epidemiology in eastern European countries will help to assess the most appropriate vaccination strategies to prevent disease due to infections with these widespread agents of acute gastroenteritis in the dog.

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Canine Coronavirus: Not Only an Enteric Pathogen

Cited by 80 publications

References 45 publications

Unveiling patterns of viral pathogen infection in free-ranging carnivores of northern Portugal using a complementary methodological approach

Unveiling patterns of viral pathogen infection in free-ranging carnivores of northern Portugal using a complementary methodological approach

Novel canine bocavirus strain associated with severe enteritis in a dog litter

Detection and genetic characterization of Canine parvovirus and Canine coronavirus strains circulating in district of Tirana in Albania

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