Canine cutaneous epitheliotropic T‐cell lymphoma: a review

Fontaine, Jacques; Bovens, C.; Bettenay, S. V.; Mueller, Ralf S.

doi:10.1111/j.1476-5829.2008.00176.x

Cited by 94 publications

(208 citation statements)

References 49 publications

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“…As a comparison, other reports suggested that cutaneous lymphoma (epitheliotrophic and nonepitheliotrophic forms) was detected in only 1% of all canine skin tumors (Goldschmidt and Shofer, 1992;Fontaine et al, 2009). We have diagnosed both epitheliotrophic skin lymphomas (57.15%), as well as non-epitheliotrophic lymphomas (42.85%).…”

Section: Resultsmentioning

confidence: 66%

Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs

Cora¹,

Gal²,

Taulescu³

et al. 2017

BUASVMCN-VM

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Round cell neoplasms (RCNs) are frequent cutaneous lesions in dogs, with high percentages among skin tumors. In this category are included histiocytoma, mast cell tumor, plasmacytoma, lymphoma and transmissible venereal tumor. The aim of the study was to perform an epidemiological study with reference to the cutaneous round cell tumors in a period of 10 years in the Department of Pathology (Faculty of Veterinary Medicine, ClujNapoca, Romania). Additionally, in the recorded cases with round cell tumors (mast cell tumor, histiocytoma and lymphoma) we described the main histological and cytological features. The epidemiological data were collected from the records of Pathology Department between 2005-2014. The investigation included dogs diagnosed with cutaneous round cell neoplasms, following necropsy analysis or assessment of biopsies or cytological samples. All collected specimens were analyzed by histopathological and/or cytological techniques. The staining used for histological investigation were Hematoxylin-eosin, Masson's trichrome and Toluidine blue, whereas Diff Quikand Wright methods were utilized in cytological specimens. The distribution of the cutaneous round cell tumors in relation to age, breed and sex was also assessed. The most frequent round cell tumor type was the mast cell tumor (19.54%) followed by histiocytoma (11.33%) and lymphoma (1.98%). The round cell tumors recorded were equally distributed in both males and females. Concerning the distribution of cutaneous RCNs by age (average age), histiocytoma occurred in 5 years old subjects, mast cell tumor in 11.9 years old subjects, and lymphoma in 6 years old subjects. Mast cell tumor was more frequent in stray dogs and Boxer breed, while histiocytoma occurred more commonly in stray dogs. Histological and cytological analysis was mandatory to perform the differential diagnosis between RCNs. Microscopic details concerning cytoplasm and nucleus of tumoral cells, together with the displaying mode in histological specimens may reveal the type of RCN. Cutaneous round cell tumors had an increased incidence, aspect observed in other reports too. The differential diagnosis has to rely on some specific microscopical features that can suggest the type of RCN.

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Section: Resultsmentioning

confidence: 66%

Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs

Cora¹,

Gal²,

Taulescu³

et al. 2017

BUASVMCN-VM

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“…Os linfomas cutâneos têm sido descritos em cães há pelo menos quatro décadas (SHADDUCK et al, 1978;PATTERSON, 1981;NAYDANT, 1994;FOSTER et al, 1997;GROSS et al, 2005;FONTAINE et al, 2009;MOORE et al, 2009;HEIMANN;DAY, 2010;MILLER;GRIFFIN;CAMPBELL, 2013) (ARAÚJO et al, 2012;DIAS et al, 2015;HERNANDEZ, 2017 GROSS et al, 2005;FONTAINE et al, 2009;MOORE et al, 2009;HEIMANN;DAY, 2010;MILLER;GRIFFIN;CAMPBELL, 2013). Não há predisposição sexual e a média de idade dos animais acometidos pela doença é de 9 anos (MOORE; GROSS et al, 2005;FONTAINE et al, 2009;MOORE et al, 2009;HEIMANN;DAY, 2010;MILLER;GRIFFIN;CAMPBELL, 2013;DIAS et al, 2015).…”

Section: Linfoma Cutâneo Caninounclassified

“…Não há predisposição sexual e a média de idade dos animais acometidos pela doença é de 9 anos (MOORE; GROSS et al, 2005;FONTAINE et al, 2009;MOORE et al, 2009;HEIMANN;DAY, 2010;MILLER;GRIFFIN;CAMPBELL, 2013;DIAS et al, 2015). Entretanto, essa correlação é ainda controversa para alguns autores (GROSS et al, 2005;FONTAINE et al, 2009;MILLER;GRIFFIN;CAMPBELL, 2013).…”

Section: Linfoma Cutâneo Caninounclassified

“…Em cães, contudo, não há comprovação de origem viral da doença (FONTAINE et al, 2009 Os aspectos clínicos da eritrodermia esfoliativa incluem eritema generalizado, hiperqueratose, hipopigmentação e alopecia e pode ser confundida com outras doenças cutâneas inflamatórias e esfoliativas; ao longo do tempo é comum o desenvolvimento de nódulos ou placas e a cabeça e o tronco são as regiões mais frequentemente afetadas, porém as lesões podem começar ou se desenvolver em qualquer região. A localização mucocutânea tem como característica eritema, despigmentação, alopecia, infiltração irregular, erosão e ulceração, sendo afetadas as junções mucocutâneas faciais da boca, plano nasal e pálpebras.…”

Section: Linfoma Cutâneo Caninounclassified

“…Os nódulos ou placas solitários ou múltiplos são geralmente eritematosos e hiperqueratóticos ou com crostas; lesões maiores podem erodir e ulcerar e um grupo de lesões pode coalescer. A doença ulcerativa da mucosa oral pode envolver gengiva, o palato ou a língua (GROSS et al, 2005;FONTAINE et al, 2009;MILLER;GRIFFIN;CAMPBELL, 2013).…”

Section: Linfoma Cutâneo Caninounclassified

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<b>Estudo da expressão imunoistoquímica de marcadores de resistência a múltiplas drogas em cães com linfoma cutâneo</b>

Alves¹

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Among mechanisms of resistance are efflux of drugs from intracellular to extracellular through ABC family transporters such as P-glycoprotein, MRP (multple resistance protein) and BCRP (breast cancer resistance protein) and LRP (lung resistance protein), a vault protein responsible for nucleocytoplasmic transport. The aim of this study was to characterize immunophenotypically cutaneous lymphomas, measure cell proliferation using the Ki67 marker, the expression of resistance proteins Pglycoprotein, MRP, BCRP and LRP and to evaluate the relationship of these proteins with the survival of the animals. A retrospective study was performed with 21 cases of dogs with cutaneous lymphoma with histopathological diagnosis.Immunohistochemical was used to immunophenotyping of lymphomas by CD3 and CD20 markers, Ki67 cell proliferation, and P-glycoprotein, MRP, BCRP and LRP expression. Of the 21 animals, 38% had histopathological diagnosis of epitheliotropic lymphoma, 52% were non-epitheliotropic lymphomas, 5% of lymphoma cases had no definition and 5% were classified as round cell neoplasia. The predominant immunophenotype was CD3+CD20-(76%), 15% of the cases were CD3-CD20 + and 9% were CD3 + CD20 +. The median of cells labeled for Ki67 was 31%. Regarding the markers of resistance to multiple drugs, the median of the P-glycoprotein label was 40%, which 65% of LRP while for MRP and BCRP, 19% and 23%, respectively. Non-epitheliotropic cutaneous lymphomas were more frequent than epitheliotropic lymphomas and the predominant immunophenotype was T. The occurrence of CD3-CD20+ and CD3+CD20+ lymphocytes indicates the need for further studies and a wider panel of antibodies for subtyping these lymphomas. P-glycoprotein had higher expression in non-epitheliotropic lymphomas than in epitheliotropic lymphomas and there was no correlation between resistance proteins and survival time of the animals, suggesting that in addition to the biology of neoplasia other mechanisms of resistance to multiple drugs different from those studied may play a relevant role in the low response of cutaneous lymphoma to chemotherapy.

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Cutaneous Epitheliotropic Lymphoma (CEL)

Esson

2015

Clinical Atlas of Canine and Feline Ophthalmic Disease

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Canine cutaneous epitheliotropic T‐cell lymphoma: a review

Cited by 94 publications

References 49 publications

Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs

Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs

<b>Estudo da expressão imunoistoquímica de marcadores de resistência a múltiplas drogas em cães com linfoma cutâneo</b>

Cutaneous Epitheliotropic Lymphoma (CEL)

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