Canine Cutaneous Spindle Cell Tumours with Features of Peripheral Nerve Sheath Tumours: A Histopathological and Immunohistochemical Study

Gaitero, Lluís; Añor, S.; Fondevila, Dolors; Pumarola, M.

doi:10.1016/j.jcpa.2008.03.003

Cited by 54 publications

(99 citation statements)

References 16 publications

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“…Concerning the tumors' location, in this research and in others (Chijiwa, Uchida & Tateyama 2004, Gaitero et al 2008, forelimbs and hindlimbs were the most affected, where large nerves are located (Hung et al 2010).…”

Section: Discussionsupporting

confidence: 58%

“…Most of the dogs studied ranged from eight to eleven years old, followed by 12-16 years old, a characteristic doc-umented by other researchers (Viott et al 2007, Gaitero et al 2008. The explanation may be found at the high age ratio x neoplasia theory.…”

Section: Discussionmentioning

confidence: 70%

“…This fact does not converge with the results obtained in this study, where the tumors marked by GFAP were mainly located in members. As noted in this study, BPNST are more often positive than MPNST, which could make this filament useful in distinguishing these variants (Enziger & Weiss 2001, Gaitero et al 2008.…”

Section: Discussionmentioning

confidence: 76%

“…Regarding sex, females were more affected than males (57% and 41% respectively), which was also suggested by Gaitero et al (2008). In dogs, it is still unproven that there is a hormonal factor explaining the relationship between sex and a higher incidence of PNST.…”

Section: Discussionmentioning

confidence: 77%

“…The explanation may be found at the high age ratio x neoplasia theory. It states that the accumulation of genetic damage over time, the decreased immune function, and a long time interval between the malignant transformation of a single cell and the emergence of a clinically detected neoplasm can be independent or interdependent explanations for the increased incidence of tumors in the last third of the animal's life (Cullen, Page & Misdorp 2002, Viott et al 2007, Gaitero et al 2008.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective canine skin peripheral nerve sheath tumors data with emphasis on histologic, immunohistochemical and prognostic factors

et al. 2015

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In this retrospective study was determined the frequency of canine skin peripheral nerve sheath tumors (PNST) in cases diagnosed by the Setor de Patologia Veterinária of the Universidade Federal do Rio Grande do Sul (SPV-UFRGS), Brazil, between the years 2000 and 2012. The canine profiles, as well as histological, immunohistochemical and prognostic aspects of the tumors were based on 70 samples, comprising 40 females, 29 males and one unspecified sample. Between 2000 and 2012, 2,984 skin tumors of dogs were diagnosed in the SPV-UFRGS, totaling 2.34% of skin neoplasms in dogs. Animals that comprised the largest amount of samples (43%) were those with no breed (SRD), followed by German Shepherds (10%). Females were more affected than males (40/70 - 57% and 29/70 - 41% respectively). Skin PNST of this research showed predominant localization on the limbs (40% in the forelimbs and 29% in the hindlimbs); affecting adult dogs, mostly aged between 8 and 11 years (54%). The samples were routinely processed for hematoxylin and eosin, and were also evaluated by toluidine blue and Masson's trichrome staining, and immunohistochemistry (IHC) anti-vimentin, -S-100, -GFAP, -actin, von Willebrand factor and neurofilament. Anisocytosis and anisokaryosis, mitotic index, intratumoral necrosis, invasion of adjacent tissues, tumor location, local recurrence and metastasis were related to the diagnosis of benign (49/70) or malignant tumor (21/70). The Antoni A histological pattern was observed more frequently in benign tumors. The immunohistochemistry helped to diagnose PNST, and anti-vimentin and anti-protein S-100 showed the highest rates of immunostaining. Throughout statistical analysis of animals with tumor recurrence, it was found that the chance of an animal with a malignant peripheral nerve sheath tumor to develop recurrence is 4.61 times higher than in an animal that had a benign tumor.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

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