Canine Distemper Virus

Appel, M. J. G.; Gillespie, J. H.

doi:10.1007/978-3-7091-8302-1_1

Cited by 129 publications

(220 citation statements)

References 161 publications

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“…As a consequence, there are few reports on the pathogenesis of CCoV infection in dogs [1,40] and its antigenic and genetic properties have not been largely investigated. Since then the development of a RT-PCR assay has provided important information on the distribution and the biology of this virus.…”

Section: Canine Coronavirus Genomic Structure and Evolutionary Changesmentioning

confidence: 99%

“…In contrast, few data of gastroenteritis in dogs clearly attributable to CCoV have been reported 1 [1,19], and only a few strains have been adapted to grow in vitro. The low detection frequency of virus isolation from faecal samples of infected dogs may also be due to the low stability of CCoV in normal environmental conditions or the low number of virus particles in the faeces at the time of sampling [25].…”

Section: Canine Coronavirus Pathogenesismentioning

confidence: 99%

“…In neonatal dogs the virus appears to replicate primarily in the villus tips of the enterocytes of the small intestine causing a lytic infection followed by desquamation and shortening of the villi. Malabsorption and deficiency of digestive enzymes follow, resulting in diarrhoea which can be seen in some dogs by 18-72 h post infection [1]. Production of local antibodies (IgAs) restricts the spread of the virus within the intestine and arrests the progress of infection.…”

Section: Canine Coronavirus Pathogenesismentioning

confidence: 99%

“…The incubation period is short and vomiting and diarrhoea may be seen by 1-3 days post infection [1]. Faeces may be mucoid or watery, sometimes streaked with blood for several days, but vomiting usually subsides after the first day of illness.…”

Section: A Pratellimentioning

confidence: 99%

“…The infected dogs generally undergo a rapid recovery, whereas fatal infections are unusual unless mixed infections by other pathogens occur. CCoV infection was first described after isolation of the virus from sentry dogs with diarrhoea during an epizootic in Germany in 1971 [1]. Since that time, most attention has been paid to the more serious canine parvovirus type 2 (CPV2)…”

Section: Introductionmentioning

confidence: 99%

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Genetic evolution of canine coronavirus and recent advances in prophylaxis

Pratelli¹

2006

Vet. Res.

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-Since the first identification of the virus in 1971, the disease caused by canine coronavirus (CCoV) has not been adequately investigated and the role that the virus plays in canine enteric illness has still not been well established. In the last decade, as a consequence of the relatively high mutation frequency of RNA positive stranded viruses, CCoV has evolved and a new genotype has been identified in the faeces of infected dogs. The several studies carried out by different researchers have focused upon the epidemiological relevance of these viruses and, considering the wide diffusion of CCoV infections among dog populations, the author underlines the need for further investigation on the biology of CCoV and on the pathogenetic role of their infections.

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Section: Canine Coronavirus Genomic Structure and Evolutionary Changesmentioning

confidence: 99%

Section: Canine Coronavirus Pathogenesismentioning

confidence: 99%

Section: Canine Coronavirus Pathogenesismentioning

confidence: 99%

Section: A Pratellimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic evolution of canine coronavirus and recent advances in prophylaxis

Pratelli¹

2006

Vet. Res.

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Dogs, distemper and Paget's disease

Mee

Sharpe

1993

BioEssays

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The cause of Paget's disease is still unknown, despite many years of intensive study. During this time, evidence has sporadically emerged to suggest that the disease may result from a slow viral infection by one or more of the Paramyxoviruses. More recently, epidemiologic and molecular studies have suggested that the canine paramyxovirus, canine distemper virus, is the virus responsible for the disease. If true, then along with rabies, this would be a further example of a canine virus causing human disease. Studies in the natural host have now supported these findings. Further investigations have proposed that the bony abnormalities seen in Paget's disease are due to the effects of the virus on osteoclastic interleukin-6 and c-FOS production, possibly via the transcription factor NF-kappa B.

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Analysis of exotic pathogens found in a large group of imported dogs following an animal welfare investigation

et al. 2023

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BackgroundIncreased dog relocation can cause dissemination of pathogen and vector populations, and this is being recognised in countries across Northern Europe, including the UK. Data regarding the prevalence of exotic infections in dogs entering the UK would be beneficial to veterinarians to help assess pets entering the UK from abroad and to help calculate the risk of establishment of novel pathogens. This study reports the findings from a group of imported dogs that was seized as part of a Royal Society for the Prevention of Cruelty to Animals (RSPCA)‐led animal welfare investigation and subsequently blood tested for exotic pathogens.MethodsAs part of the RSPCA investigation, 151 dogs were removed from the site. Blood tests were performed for Babesia canis, Ehrlichia canis, Hepatozoon canis and Leishmania infantum by PCR, Brucella canis by antibody serology and Dirofilaria immitis by blood antigen. In addition to pathogen screening, a serology titre for rabies was measured for each dog. A clinical examination was performed by a veterinary surgeon, and clinical signs were recorded.ResultsOverall, 24% (32/133) of the dogs tested positive for an infection with one or more exotic pathogens. Two dogs were positive for Br. canis antibodies and had no clinical signs indicative of infection. Leishmania was identified in 10.5% (14/133) of dogs, and all but two of these were implanted with microchips of Romanian origin. H. canis was identified in 9.6% (10/104) of dogs, all of whom had a Romanian microchip. D. immitis was identified in 4.1% (5/121) of dogs, B. canis in 2.3% (3/129) of dogs and E. canis in only 1.5% (2/131) of dogs tested. Only four dogs were found to have co‐infections. No significant association was found between the pathogens detected and presenting clinical signs.LimitationsThis was a group of rescued dogs that were tested for a range of pathogens. They were not randomly selected and as such do not represent the true prevalence of these pathogens in dogs imported into the UK.ConclusionsThis study demonstrates a range of exotic pathogens entering the UK, including Br. canis, and demonstrates the importance of screening imported dogs. The emphasis on early recognition of exotic pathogens in imported dogs has relied on screening based on relevant clinical signs and the country of origin. While these factors are useful, this study demonstrated no significant association between presenting clinical signs and the pathogens carried.

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Canine Distemper Virus

Cited by 129 publications

References 161 publications

Genetic evolution of canine coronavirus and recent advances in prophylaxis

Genetic evolution of canine coronavirus and recent advances in prophylaxis

Dogs, distemper and Paget's disease

Analysis of exotic pathogens found in a large group of imported dogs following an animal welfare investigation

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