Canine epidermolysis bullosa acquisita: a retrospective study of 20 cases

Abstract

Canine EBA is a rare subepidermal blistering disease with an inflammatory phenotype and a predilection for young great danes and male dogs. The outcome of treatment appears more favourable than assumed previously.

Mucous membrane pemphigoid in dogs: a retrospective study of 16 new cases

“…Occasional basal keratinocyte apoptosis and pigmentary incontinence were observed and were considered nonspecific, as both can be seen with other subepidermal blistering diseases and with injured hyperplastic epidermis or mucosa generically. Additionally, the occasional keratinocyte apoptosis in AISBDs could also be the result of anoikis, a form of apoptosis triggered by a loss of the cell attachment to the appropriate matrix .…”

“…Dermal inflammation often contained eosinophils, which is also described in canine epidermolysis bullosa acquisita (EBA) and BP, but their numbers were usually low in the MMP. Although neutrophils and eosinophils were common in the dermis, inflammation targeted the BMZ in only few cases, where it overlapped with the inflammatory patterns described for canine EBA . Much of the moderate‐to‐marked inflammation in the dermis and submucosa was considered secondary and it was likely attributable to bacterial infection, ulcers and/or a chronic generic response of mucosal or mucocutaneous tissue to injury; this was often seen as a lymphoplasmacytic (lichenoid) band pattern.…”

“…Ulcers were common. Dermal inflammation often contained eosinophils, which is also described in canine epidermolysis bullosa acquisita (EBA) and BP, but their numbers were usually low in the MMP. Although neutrophils and eosinophils were common in the dermis, inflammation targeted the BMZ in only few cases, where it overlapped with the inflammatory patterns described for canine EBA .…”

“…Fibrosis is a recognized clinical feature of MMP in humans and dogs . In this study, superficial dermal or submucosal fibrosis was seen more commonly histologically than in previous reports of canine MMP or EBA . However, the degree of fibrosis varied from absent to marked in biopsies from the same dog and, by itself, fibrosis is not expected to differentiate canine MMP from other subepidermal clefting diseases.…”

“…Tissue samples from 11 dogs were available for further review by one of the authors. Histological sections were stained with haematoxylin and eosin and evaluated as described previously …”