Canine, feline, and equine corneal vascular neoplasia: A retrospective study (2007‐2015)

Shank, Alba Maria M.; Teixeria, Leandro; Dubielzig, Richard R.

doi:10.1111/vop.12571

Cited by 15 publications

(30 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are few reports of corneal vascular tumors (hemangiosarcoma and hemangioma) in cats. 38,39 In a 2011 case report, Cazalot and colleagues performed a lamellar keratectomy to the mid-stroma followed by superficial diathermy and a nictitating membrane flap for management of a hemangiosarcoma. The histopathology showed complete margins, but the mass eventually regrew, and the owner ultimately elected enucleation.…”

Section: Feline Corneal Disease: When Is Surgery Indicated?mentioning

confidence: 99%

See 1 more Smart Citation

Corneal Surgery in the Cat: Diseases, considerations and techniques

Telle

Betbeze

2021

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Practical relevance: The ability to recognize, diagnose and treat corneal disease is essential for maintaining vision and comfort in feline patients. Being able to correctly identify appropriate techniques for surgical cases is of particular importance for success when performing corneal surgery. Clinical challenges: Many different corneal diseases present with similar clinical signs, and it can be hard to determine the appropriate treatment for individual patients. It is essential for the clinician to understand the indications for corneal surgery, instrumentation needed and microsurgical principles prior to attempting these procedures. The prognosis following surgery and potential complications should be discussed with the client. Audience: This review article aims to assist in decision-making and to provide detailed guidance for primary care clinicians considering referral of cats for corneal surgery. The review outlines common feline corneal diseases and associated surgical therapies performed by veterinary ophthalmologists, highlighting appropriate instrumentation and case selection. Some surgeries are explained in depth for ophthalmologists and residents in training. Equipment: Although some procedures may be performed with common surgical equipment and supplies, most require specialized ophthalmic instrumentation and expertise, which entails significant microsurgical training and practice, as well as financial investment. Most of the procedures require an operating microscope for the best surgical outcomes; however, surgical loupes may be sufficient in some cases. Evidence base: This review article compiles information from many published references on feline corneal diseases and surgeries, complemented by the experience of the authors.

show abstract

Section: Feline Corneal Disease: When Is Surgery Indicated?mentioning

confidence: 99%

“…Still, pathologic changes including vascularization, chronic inflammation and exposure to ultraviolet radiation can lead to formation of squamous cell carcinoma (SCC), hemangioma and hemangiosarcoma, and these tumors have been documented in the feline cornea or at the limbus. 36-39…”

Section: Feline Corneal Disease: When Is Surgery Indicated?mentioning

confidence: 99%

Corneal Surgery in the Cat: Diseases, considerations and techniques

Telle

Betbeze

2021

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…Physiologically, the cornea is an avascular tissue that maintains its transparency by regulating its optimal consistency based on an equilibrium of pro‐ and anti‐angiogenic factors including endostatin, angiostatin and MMPs. Any disequilibrium of factors, which may be the case in hypoxia or inflammatory diseases, initiates angiogenesis in the cornea (Shank, Teixeria, & Dubielzig, 2019).…”

Section: Angiogenesis Research In Equine Reproductionmentioning

confidence: 99%

Endothelial cells and angiogenesis in the horse in health and disease—A review

Rieger

Kaessmeyer

Masri

et al. 2020

Anat Histol Embryol

View full text Add to dashboard Cite

The cardiovascular system is the first functional organ in the embryo, and its blood vessels form a widespread conductive network within the organism. Blood vessels develop de novo, by the differentiation of endothelial progenitor cells (vasculogenesis) or by angiogenesis, which is the formation of new blood vessels from existing ones. This review presents an overview of the current knowledge on physiological and pathological angiogenesis in the horse including studies on equine endothelial cells. Principal study fields in equine angiogenesis research were identified: equine endothelial progenitor cells; equine endothelial cells and angiogenesis (heterogeneity, markers and assessment); endothelial regulatory molecules in equine angiogenesis; angiogenesis research in equine reproduction (ovary, uterus, placenta and conceptus, testis); angiogenesis research in pathological conditions (tumours, ocular pathologies, equine wound healing, musculoskeletal system and laminitis). The review also includes a table that summarizes in vitro studies on equine endothelial cells, either describing the isolation procedure or using previously isolated endothelial cells. A particular challenge of the review was that results published are fragmentary and sometimes even contradictory, raising more questions than they answer. In conclusion, angiogenesis is a major factor in several diseases frequently occurring in horses, but relatively few studies focus on angiogenesis in the horse. The challenge for the future is therefore to continue exploring new therapeutic angiogenesis strategies for horses to fill in the missing pieces of the puzzle.

show abstract

“…Commonly, tumors occurring on the lateral bulbar conjunctiva invade the cornea 5,10–12,18,21,24 . Primary corneal vascular tumors have also been reported 26 . Tumors are typically unilateral but bilateral lesions have been reported 11,12 …”

Section: Introductionmentioning

confidence: 99%

Surgical treatment of conjunctival hemangioma and hemangiosarcoma: A retrospective study of 52 dogs

Richardson

Deykin

2021

Veterinary Ophthalmology

View full text Add to dashboard Cite

Objective To review cases of canine conjunctival hemangioma (HA) and hemangiosarcoma (HSA) treated surgically at a referral center to establish success of surgical management, recurrence rates, and long‐term outcomes for patients. Animals Studied Retrospective record review of dogs that underwent surgery to remove histologically diagnosed conjunctival HA or HSA between April 2004 and April 2020 to collect data on signalment, tumor location, interval between initial presentation and surgery, tumor diagnosis, surgical dose, surgical margins, tumor size, recurrence and survival times. Results A total of 52 dogs (60 tumors) were included. The mean age of affected dogs was 8.69 years; the most affected breed was the Border collie (n = 13, 25%). 28 tumors were HA (46.67%) and 32 HSA (53.33%). Tumors occurred in three locations: the lateral bulbar conjunctiva (n = 37, 61.67%), the third eyelid margin (n = 19, 31.67%), and the ventral conjunctival fornix (n = 4, 6.67%). There was no site predilection for HA versus HSA. 97% of tumors occurred in non‐pigmented tissue. Corneal invasion was more likely to be a feature of malignant tumors. Five tumors were incompletely excised, one of which recurred. There was no statistical difference in likelihood of incomplete excision between HSA and HA. Six tumors (10%) recurred. HSA was not statistically more likely to recur than HA. Recurrence times ranged from 5 weeks to 1 year. Conclusion Surgical treatment of conjunctival HA and HSA is likely to be curative. There is a recurrence rate of 10% regardless of tumor type, and recurrence may be late in the course of the disease.

show abstract

Canine, feline, and equine corneal vascular neoplasia: A retrospective study (2007‐2015)

Cited by 15 publications

References 37 publications

Corneal Surgery in the Cat: Diseases, considerations and techniques

Corneal Surgery in the Cat: Diseases, considerations and techniques

Endothelial cells and angiogenesis in the horse in health and disease—A review

Surgical treatment of conjunctival hemangioma and hemangiosarcoma: A retrospective study of 52 dogs

Contact Info

Product

Resources

About