Вісник проблем біології і медицини -2024 -Вип. 2 (173) / Bulletin of problems in biology and medicine -2024 -Issue 2 (173)
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МОРФОЛОГІЯ / MORPHOLOGYMethods and Material. The massometric parameters of the parts of the heart of 4 groups of 120 male white ferrets were studied. The first group consisted of 30 intact six-month-old experimental animals, the second -30 similar laboratory male rats aged 24 months, the third -30 six-month-old experimental animals injected with cobalt chloride, the fourth -30 24-month-old rats with intoxication with cobalt chloride, which was administered intragastrically daily rats at a dose of 4 mg/kg for 30 days. Animals were euthanized by bloodletting under anesthesia. In the heart, the left and right ventricles, left and right atria, interventricular and interatrial septa were isolated and weighed, ventricular, atrial, Fulton indices and percentages of the masses of heart parts were determined. Quantitative indicators were processed statistically.Results and Discussion. It was established that the administration of cobalt chloride to white male laboratory rats leads to a pronounced uneven, unbalanced growth of fat in the left and right ventricles, atria, interventricular and interatrial septa. The masses of the left ventricle and the left atrium increased the most, which was confirmed by the indices of the ventricles, atria, and Fulton. The ventricular index in six-month-old rats decreased by 3.6% (p<0.01), the Fulton index increased by 3.4% (p<0.01), the atrial index -by 2.7% (p<0.05), in 24-month-old experimental animals -the given morphometric parameters changed accordingly -by 9.6%, 6.0% and 4.3% (р<0.001).