Canine Leishmaniasis Control in the Context of One Health

Dantas‐Torres, Filipe; Miró, Guadalupe; Baneth, Gad; Bourdeau, P.; Breitschwerdt, Edward B.; Capelli, Gioia; Cardoso, Luı́s; Day, Michael; Dobler, Gerhard; Ferrer, Luis Enrique Rosabal; Irwin, Peter; Jongejan, Frans; Kempf, Volkhard A. J.; Kohn, Barbara; Lappin, Michael R.; Little, Susan Haynes; Madder, Maxime; Maggi, Ricardo G.; Maia, Carla; Marcondes, Mary; Naucke, Torsten J.; Oliva, Gætano; Pennisi, Maria Grazia; Penzhorn, Barend Louis; Peregrine, Andrew S.; Pfeffer, Martin; Roura, Xavier; Sainz, Á.; Shin, Sung Shik; Solano‐Gallego, Laia; Straubinger, Reinhard K.; Tasker, Séverine; Traub, Rebecca; Wright, I. P.; Bowman, Dwight D.; Gradoni, Luigi; Otranto, Domenico

doi:10.3201/eid2512.190164

Cited by 83 publications

(89 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The educational role of veterinarians is essential to explain the life-cycle of the parasite and how other animals or people could acquire the infection, highlighting the importance of control and prevention measures [21,22]. Veterinarians also need to make owners aware that culling CanL positive dogs is not an adequate disease control measure, as confirmed in studies conducted in Brazil where culling seropositive dogs failed to reduce the incidence of canine or human leishmaniosis [90][91][92].…”

Section: Discussionmentioning

confidence: 99%

Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Canine leishmaniosis (CanL) is a parasitic zoonotic disease, endemic in the Mediterranean basin including Spain. While knowledge about CanL, its management, treatment, prevention and control mounts, it remains unclear whether all clinical veterinarians follow the same international recommendations, such as those of the LeishVet group. This study was thus designed to assess recent trends in the clinical management of CanL in veterinary clinics across Spain through a questionnaire-based survey. Results were compared with those of a prior national multicenter questionnaire administered by our research team in 2005.

show abstract

Section: Discussionmentioning

confidence: 99%

Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, this intervention could serve as complementary tool as part of a One Health multimodal approach together with other immunotherapy options [ 35 ]. In fact, recent publications include nucleotides and AHCC within the choices of effective immunotherapies for the management and control of CanL [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Nucleotides and AHCC Enhance Th1 Responses In Vitro in Leishmania-Stimulated/Infected Murine Cells

et al. 2020

View full text Add to dashboard Cite

A stronger Th1 (cellular) immune response in canine leishmaniosis (CanL) leads to a better prognosis. Dietary nucleotides plus AHCC® have shown beneficial effects in dogs with clinical leishmaniosis and in clinically healthy Leishmania-infected dogs. The potential leishmanicidal activity of nucleotides and AHCC was assessed by quantifying nitric oxide (NO) production and replication of parasites. Their effects on lymphocyte proliferation were studied with and without soluble Leishmania infantum antigen (SLA) stimulation. Cytokine level variations were assessed using naïve and L. infantum-infected macrophages/lymphocytes cocultures. Promastigotes and amastigotes proliferation and NO macrophage production were not directly affected. Lymphocyte proliferation was significantly enhanced by nucleotides, AHCC, and their combinations only after SLA stimulation. Nucleotides and AHCC significantly increased the production of IL-1β, IL-2, IL-5, IL-9, IL-10, and IL-12 by naïve immune cells. In naïve and L. infantum-infected macrophage/lymphocyte cocultures, nucleotides with or without AHCC led to significant increases in IFN-γ and TNF-α. Given that these cytokines are involved in the effective Th1 immune response against Leishmania parasites, these mechanisms of action could explain the previously reported in vivo clinical efficacy of such combination and further support the use of nucleotides with or without AHCC in the management of CanL patients.

show abstract

“…The educational role of veterinarians is essential to explain the life cycle of the parasite and how other animals or people could acquire the infection, highlighting the importance of control and prevention measures [21,22]. Veterinarians also need to make owners aware that culling CanL positive dogs is not an adequate disease control measure, as confirmed in studies conducted in Brazil where culling seropositive dogs failed to reduce the incidence of canine or human leishmaniosis [83,84,85].…”

Section: Discussionmentioning

confidence: 99%

Latest trends in L. infantum infection in dogs in Spain (Part II): current clinical management and control according to a national survey in practitioners

Montoya

Gálvez

Checa

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background Canine leishmaniosis (CanL) is a parasitic zoonotic disease, endemic in the Mediterranean basin including Spain. While knowledge about CanL, its management, treatment, prevention and control mounts, it remains unclear whether all clinical veterinarians follow the same international recommendations, such as those of the LeishVet group. This study was thus designed to assess recent trends in the clinical management of CanL in veterinary clinics across Spain through a questionnaire-based survey. Results were compared with those of our prior national multicenter questionnaire administered by our research team in 2005. Methods A questionnaire consisting of 28 questions about CanL was developed using Google Forms and distributed by email to 1428 veterinary clinics in Spain. Questions were designed to obtain data on common clinical signs, techniques and complementary exams used to diagnose the disease, and on its monitoring, treatment and control measures. Data were collected in a database for statistical analysis. Results Completed questionnaires were returned by 295 clinics. Compared to the situation in 2005, replies indicate that clinical signs of CanL have not changed significantly, cutaneous lesions being still the most prevalent sign observed by practitioners. Quantitative serological techniques are considered an adequate approach to diagnosis, provided their results are supported by the findings of a thorough physical exam, as well as complementary tests (complete blood count (CBC), biochemical profile, plasma protein electrophoretogram and complete urinalysis). Treatment protocols and check-ups follow international recommendations. Finally, a multimodal approach is being endorsed to adequately control CanL including preventive measures such as: annual serological check-ups and the combination of repellents and vaccines. Besides, owners are being better informed about CanL by veterinarians, which translates to the improved control of this zoonosis. Conclusions The clinical management of CanL has recently undergone significant changes owing to improvements in clinical knowledge of the disease, more unified international criteria, improved diagnostic techniques and their adequate interpretation, as well as a greater awareness of the disease transmitted to owners.

show abstract

Canine Leishmaniasis Control in the Context of One Health

Cited by 83 publications

References 26 publications

Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners

Latest trends in L. infantum infection in dogs in Spain, Part II: current clinical management and control according to a national survey of veterinary practitioners

Nucleotides and AHCC Enhance Th1 Responses In Vitro in Leishmania-Stimulated/Infected Murine Cells

Latest trends in L. infantum infection in dogs in Spain (Part II): current clinical management and control according to a national survey in practitioners

Contact Info

Product

Resources

About