Canine Leproid Granuloma (CLG) Caused by Mycobacterial Species Closely Related to Members of Mycobacterium Simiae Complex in a Dog in Brazil

Biezus, Giovana; Cristo, Thierry Grima de; Ikuta, Cássia Yumi; Carniel, Felipe; Volpato, Julieta; Teixeira, Marcela Brüggemann de Souza; Neto, José Soares Ferreira; Casagrande, Renata Assis

doi:10.1016/j.tcam.2022.100672

Cited by 4 publications

(5 citation statements)

References 20 publications

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“…Boxers are predisposed to this infectious disease, suggesting a genetic predisposition [ 14 , 63 , 64 ]. Disease, caused by mycobacterial strains of the Mycobacterium simiae clade in association with trauma, previous skin lesions, and insect bites, is most prevalent in Australia, the USA, and South America (Brazil) [ 170 ]. Affected individuals show multiple, intact to ulcerated, well-demarcated nodules and plaques on the head (especially pinnae) and limbs but are otherwise healthy [ 170 ].…”

Section: Skin Diseases In Brachycephalic Breeds That Are Not Directly...mentioning

confidence: 99%

“…Disease, caused by mycobacterial strains of the Mycobacterium simiae clade in association with trauma, previous skin lesions, and insect bites, is most prevalent in Australia, the USA, and South America (Brazil) [ 170 ]. Affected individuals show multiple, intact to ulcerated, well-demarcated nodules and plaques on the head (especially pinnae) and limbs but are otherwise healthy [ 170 ]. The diagnosis is based on clinical, cytological (acid-fast bacilli), and histopathological findings [ 170 ].…”

Section: Skin Diseases In Brachycephalic Breeds That Are Not Directly...mentioning

confidence: 99%

“…Affected individuals show multiple, intact to ulcerated, well-demarcated nodules and plaques on the head (especially pinnae) and limbs but are otherwise healthy [ 170 ]. The diagnosis is based on clinical, cytological (acid-fast bacilli), and histopathological findings [ 170 ]. Although there is a chance for spontaneous remission within one to three months, systemic treatment with azithromycin and rifampicin with or without surgery may be needed, particularly in more severe and refractory cases [ 170 ].…”

Section: Skin Diseases In Brachycephalic Breeds That Are Not Directly...mentioning

confidence: 99%

“…The diagnosis is based on clinical, cytological (acid-fast bacilli), and histopathological findings [ 170 ]. Although there is a chance for spontaneous remission within one to three months, systemic treatment with azithromycin and rifampicin with or without surgery may be needed, particularly in more severe and refractory cases [ 170 ]. Topical formulations may be supportive [ 171 ].…”

Section: Skin Diseases In Brachycephalic Breeds That Are Not Directly...mentioning

confidence: 99%

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Dermatological Problems of Brachycephalic Dogs

Hobi

Barrs

Bęczkowski

2023

Animals

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Brachycephalic dogs are not only affected by brachycephalic obstructive airway syndrome (BOAS), but are also frequently referred to veterinary dermatologists for skin conditions, with English bulldogs and pugs particularly over-represented. Some skin diseases, such as skin fold dermatitis, are directly associated with the abnormal anatomic conformation of brachycephalic dogs, while for others, such as atopic dermatitis and viral pigmented plaques, there is an underlying genetic basis or a general predisposition. Anatomic alterations associated with brachycephaly, leading to fold formation of the skin and stenosis of the ear canal, together with primary immunodeficiencies described in some breeds, favor the development of pyoderma, Malassezia dermatitis, and otitis externa/media. In addition, the frequently neglected but often lifelong dermatological problems of brachycephalic dogs are an important consideration when discussing genetic and medical conditions affecting the welfare of those dogs. Here we review the current state of knowledge concerning dermatological problems in brachycephalic dogs and combine it with clinical experience in the management of these challenging disorders.

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Section: Skin Diseases In Brachycephalic Breeds That Are Not Directly...mentioning

confidence: 99%

Section: Skin Diseases In Brachycephalic Breeds That Are Not Directly...mentioning

confidence: 99%

Section: Skin Diseases In Brachycephalic Breeds That Are Not Directly...mentioning

confidence: 99%

Section: Skin Diseases In Brachycephalic Breeds That Are Not Directly...mentioning

confidence: 99%

See 2 more Smart Citations

Dermatological Problems of Brachycephalic Dogs

Hobi

Barrs

Bęczkowski

2023

Animals

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“…A micobacteriose cutânea, também conhecida como granuloma leproide canino (GLC), é uma dermatose nodular que pode acometer regiões cutânea e subcutânea, decorrente de uma infecção por espécies de micobactérias saprófitas altamente exigentes e até o momento ainda não isoladas em culturas (Biezus et al, 2022;Greene, 2015;Gunn-Moore et al, 2010;Malik et al, 2013). Essa doença não é comumente relatada, com exceção nos países de clima tropical (Wurster et al, 2017) e geralmente tende a ser autolimitante em cães que desenvolvem a forma granulomatosa (Malik et al, 1998).…”

Section: Introductionunclassified

Granuloma lepróide em um canino imunossuprimido: relato de caso

Silva

Klaser²,

Costa³

et al. 2022

RSD

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O granuloma lepróide canino é uma dermatose nodular que pode acometer regiões cutânea e subcutânea, geralmente com localização em orelhas e extremidades. Sabe-se que a imunidade dos cães é uma importante aliada tanto para o combate ao seu desenvolvimento, como também para que ocorra a regressão espontânea em animais acometidos sem exérese cirúrgica ou uso de antibacterianos. Devido a isso, este trabalho tem por objetivo relatar um caso de granuloma lepróide em um cão, diagnosticado por citopatológico, dando ênfase em seu aparecimento secundário à imunossupressão resultante de tratamento quimioterápico prévio. O canino, macho, sem raça definida, de 9 anos e pesando 29,4kg foi atendido no Hospital Veterinário da Universidade de Passo Fundo, no Rio Grande do Sul, com queixa de lesão ulcerada e sanguinolenta no pênis. Foi realizada citologia por agulha fina e diagnosticado com tumor venéreo transmissível. Após a sexta sessão quimioterápica com sulfato de vincristina, apresentou nódulo em face externa da orelha esquerda medindo 1,5x1,2cm, de consistência firme, aspecto regular, não inflamado e aderido. Foram realizados citopatológico e coloração especial com Ziehl-Neelsen confirmando se tratar de uma inflamação granulomatosa decorrente de uma infecção causada por Mycobacterium spp. Enfatiza-se que a resposta imunológica do paciente é um importante variável a ser considerado no aparecimento de granuloma lepróide canino. E assim, esse diagnóstico diferencial deve sempre ser considerado em pacientes que passam a apresentar alterações cutâneas nodulares após estipulação de protocolos quimioterápicos.

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Dermatological Problems of Brachycephalic Dogs

Hobi¹,

Barrs²,

Bęczkowski³

2023

Preprint

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Brachycephalic dogs are not only affected by brachycephalic obstructive airway syndrome (BOAS), but also comprise up to 30% of canine patients seen by veterinary dermatologists, with English Bulldogs and Pugs particularly overrepresented. Some skin diseases are associated with the abnormal anatomic conformation of brachycephalic dogs, while for others there is a underlying genetic basis or a general predisposition. Anatomic alterations associated with brachycephaly, leading to fold formation of the skin and stenosis of the ear canal, together with primary immunodeficiencies described in some breeds, favor the development of pyoderma, Malassezia dermatitis and otitis externa/media. Frequently neglected but often lifelong dermatological problems of brachycephalic dogs are an important consideration when discussing genetic and medical conditions affecting the welfare of those dogs. Here we review the current state of knowledge concerning dermatological problems of brachycephalic dogs, and combine it with clinical experience in the management of these challenging disorders.

show abstract

Canine Leproid Granuloma (CLG) Caused by Mycobacterial Species Closely Related to Members of Mycobacterium Simiae Complex in a Dog in Brazil

Cited by 4 publications

References 20 publications

Dermatological Problems of Brachycephalic Dogs

Dermatological Problems of Brachycephalic Dogs

Granuloma lepróide em um canino imunossuprimido: relato de caso

Dermatological Problems of Brachycephalic Dogs

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