Canine Mammary Tumours, an Overview

Sleeckx, N.; Rooster, H. de; Kroeze, Edwin Veldhuis; Ginneken, Chris Van; Brantegem, Leen Van

doi:10.1111/j.1439-0531.2011.01816.x

Cited by 203 publications

(275 citation statements)

References 199 publications

(336 reference statements)

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“…Histological grading of the canine mammary carcinoma is significantly related to prognosis: a high histological grade is associated with low overall survival (25). In the present study, although the types of the tumours were not equal in number, 50% of simple solid carcinomas were grade III, whereas complex adenocarcinomas and simple tubulopapillary carcinomas were mostly grade I.…”

Section: Discussionmentioning

confidence: 56%

Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

Şennazlı

Yıldırım

Arun

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The objective of this study was to investigate the correlation between different histological types and grades of canine malignant mammary tumours, tumour cell proliferation and their angiogenic activity using immunohistochemical markers. Mammary tissue samples from 47 bitches with mammary cancer were evaluated. The expression of cellular proliferation marker Ki-67 and endothelial marker Von Willebrand's factor (vWF) were immunohistochemically demonstrated. The tumours with the highest Ki-67 and vWF expressions were found to share similar histomorphological features. Simple solid carcinoma had the highest levels of Ki-67, vWF, and higher histological grade while complex carcinomas, osteosarcomas, and carcinosarcomas had the lowest ones. The differences between the expressions of Ki-67 and vWF in different tumour types were considered to be of great importance in determination of biological behaviour and prognosis of these tumours. This study is one of the few studies that evaluate these differences among the subtypes of malignant canine mammary tumours.

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Section: Discussionmentioning

confidence: 56%

Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

Şennazlı

Yıldırım

Arun

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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“…Although clearly metastatic or invasive tumours can be distinguished from tumours that have no capacity to spread from the original site, the dividing line between malignant and benign tumours, that is, cancer as opposed to noncancerous or precancerous growths, is not as distinct as the language would imply. This ambiguity is present histologically within an accepted transition from precancerous to cancerous neoplasia [91,99] and becomes even more problematic for defining the boundary of benign neoplasias that are not yet linked to a malignancy. Cutaneous fibromas, for example, frequently occur in wild populations of deer and elk and are caused by papillomaviruses [110,111].…”

Section: (C) Associations Between Benign and Malignant Neoplasiasmentioning

confidence: 99%

“…Although the status of these tumours as malignant or non-malignant neoplasias was debated for a century, the metastatic potential of the tumours indicates that MMTV is a cancer-causing virus [89]. Mammary neoplasms are common in both canines and domestic cats, with malignancy rates in dogs at approximately 50% [90,91] and cats closer to 90% [92]. Possible viral aetiology in these domestic animal mammary cancers have been reviewed or investigated [90,93,94].…”

Section: Infectious Cancers In Vertebrates (A) Historical Trendmentioning

confidence: 99%

Infection and cancer in multicellular organisms

Ewald

2015

Phil. Trans. R. Soc. B

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Evolutionary considerations suggest that oncogenic infections should be pervasive among animal species. Infection-associated cancers are well documented in humans and domestic animals, less commonly reported in undomesticated captive animals, and rarely documented in nature. In this paper, we review the literature associating infectious agents with cancer to evaluate the reasons for this pattern. Non-malignant infectious neoplasms occur pervasively in multicellular life, but oncogenic progression to malignancy is often uncertain. Evidence from humans and domestic animals shows that non-malignant infectious neoplasms can develop into cancer, although generally with low frequency. Malignant neoplasms could be difficult to find in nature because of a low frequency of oncogenic transformation, short survival after malignancy and reduced survival prior to malignancy. Moreover, the evaluation of malignancy can be ambiguous in nature, because criteria for malignancy may be difficult to apply consistently across species. The information available in the literature therefore does not allow for a definitive assessment of the pervasiveness of infectious cancers in nature, but the presence of infectious neoplasias and knowledge about the progression of benign neoplasias to cancer is consistent with a widespread but largely undetected occurrence.

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“…Canine mammary tumours are the most common neoplasms in intact female dogs and approximately half of these tumours are malignant (26). It is accepted that canine mammary tumours share many epidemiologic, clinical, morphologic and prognostic features with human breast cancer and therefore represent a comparative model to understand the underlying molecular mechanisms of carcinogenesis in both species (16).…”

Section: Praca Oryginalnamentioning

confidence: 99%

Circulating concentrations of insulin like growth factor-1 in female dogs with spontane-ous mammary tumours

Szczubiał¹,

Dąbrowski²,

Łopuszyński³

et al. 2018

Medycyna Weterynaryjna

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SummaryThe aim of this study was the investigation of the circulating concentration of IGF-1 in female dogs with spontaneous mammary tumours. The study was performed on 34 female dogs undergoing surgery due to spontaneously occurring mammary gland tumours (24 malignant and 10 benign) and 10 clinically healthy female dogs. The serum concentrations of IGF-1 were determined by specific ELISA Kit assay. The mean concentrations of IGF-1 were significantly higher (P < 0.05) both in dogs with malignant (173.35 ± 120.45 ng/ml) and benign (130.58 ± 59.0 ng/ml) mammary tumours than in healthy controls (117.45 ± 71.0 ng/ml). In the group of female dogs with mammary carcinomas, the mean concentration of IGF-1 gradually increased from 132.85 ± 65.64 ng/ml in dogs with grade 1 tumours to 317.74 ± 119.25 ng/ml in those with grade 3 tumours, and significant differences (P < 0.05) were found among dogs with various grade tumours. These findings suggest that circulating IGF-1 may play an important role in the pathogenesis of canine mammary tumour. Moreover, high IGF-1 levels may reflect tumour cell differentiation into a more aggressive phenotype.

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Canine Mammary Tumours, an Overview

Cited by 203 publications

References 199 publications

Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

Immunohistochemical detection of tumour cell proliferation and intratumoural microvessel density in canine malignant mammary tumours

Infection and cancer in multicellular organisms

Circulating concentrations of insulin like growth factor-1 in female dogs with spontane-ous mammary tumours

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