Canine models of allergic skin disease

Marsella, Rosanna

doi:10.1111/vde.12311

Cited by 2 publications

(4 citation statements)

References 12 publications

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“…B. Leishmanien (Sandmücke), Onchocerca spp. (Simuliidae, Culicoides spp., s. Exkurs), dem West-Nil-Virus (Culicidae) oder dem Afrikanischen Pferdepestvirus ( Culicoides spp., Culicidae) 3 , 6 .…”

Section: Ektoparasiten Des Pferdes In Mitteleuropaunclassified

“…Bei einem sehr starken Befall durch Kriebelmücken kann es selten auch zu einem allergischen Schock bis hin zum Tod der betroffenen Tiere kommen. Es werden als Auslöser der Histamingehalt wie auch Toxine im Speichel der Mücke diskutiert 2 , 3 , 6 .…”

Section: Ektoparasiten Des Pferdes In Mitteleuropaunclassified

“…Es gibt jedoch mehrere widersprüchliche Studien, was die Aussagekräftigkeit der Diagnostik betrifft, und somit wird dieser derzeit höchstens als zusätzlicher Test empfohlen. Im Fall der Hypersensitivitätsreaktion auf Insektenstiche ergibt sich die Diagnose durch die Anamnese, klinische Symptomatik, Ausschluss anderer Dermatosen sowie eine positive Entwicklung nach adäquater Insektenkontrolle 6 .…”

Section: Diagnostikunclassified

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Behandlung von Ektoparasiten beim Pferd

Frisch,

Pikalo

2023

pferde spiegel

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Section: Ektoparasiten Des Pferdes In Mitteleuropaunclassified

Section: Diagnostikunclassified

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Behandlung von Ektoparasiten beim Pferd

Frisch,

Pikalo

2023

pferde spiegel

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“…Notably, dogs, cats and horses develop AD-like lesions spontaneously. [21] Of these, canine AD models are frequently used as their phenotype and clinical symptoms closely resemble those of human AD. [22] Irrespective of the fact they do not spontaneously develop eczematous lesion, mice are the most commonly used AD models because of their relatively low costs, short time to maturity and highly tractable genetic manipulation.…”

Section: Animal Models Of Atopic Dermatitismentioning

confidence: 99%

Alternatives to animal testing in basic and preclinical research of atopic dermatitis

Löwa

Jevtić

Gorreja

et al. 2018

Experimental Dermatology

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Atopic dermatitis (AD) is a chronic inflammatory skin disease of increasing prevalence, especially in industrialized countries. Roughly 25% of the children and 1%-3% of adults are affected. Although significant progress has been made in the understanding of the pathogenesis of AD, many aspects remain poorly understood. Moreover, there is a pressing need for improved therapeutic options. Studies to elucidate the pathophysiological pathways of AD and to identify novel therapeutic targets over the last few decades have been conducted almost exclusively in animal models. However, in vitro approaches such as 3D skin disease models have recently emerged due to an increasing awareness of distinct interspecies-related differences that hamper the effective translation of results from animal models to humans. In addition, there is growing political and social pressure to develop alternatives to animal models according to the 3Rs principle (reduction, refinement and replacement of animal models). K E Y W O R D S3R approach, atopic dermatitis, preclinical dermatology, skin equivalents, skin model

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Canine models of allergic skin disease

Cited by 2 publications

References 12 publications

Behandlung von Ektoparasiten beim Pferd

Behandlung von Ektoparasiten beim Pferd

Alternatives to animal testing in basic and preclinical research of atopic dermatitis

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