Canine models of asthma and COPD

Chapman, Richard W.

doi:10.1016/j.pupt.2008.01.003

Cited by 34 publications

(24 citation statements)

References 125 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…35) Although several methods 14,[36][37][38][39] have been used to cause COPD or emphysema in animals, the complications seen in human COPD are frequently not found in these experimental COPD animal models or their long term consistency over time has not been determined. Therefore, these animal models are only used in short-term observation and are not suitable for long term research and for clarifying the mechanisms of COPD.…”

Section: Discussionmentioning

confidence: 99%

“…Previous experimental COPD or emphysema models have been developed in guinea pigs. 14) mice, 36,37) rats, 38) and dogs 39) by exposing the animals to sulfur dioxide (SO 2 ), 17) smoke from solid fuel, 19) cigarette smoke, 14,24,42) lipopolysaccharide, 39) proteases and their secretagogues, such as PAE, PPE, NE, proteinase 3, MMP, 44,48,49) and the factors used can enhance the effect of each other. 50,51) However, the rat model seems to be more economical and more feasible, and smoke and bacterial infections appear to be the most frequently used initiators.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Rat Model for Stable Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke Inhalation and Repetitive Bacterial Infection

et al. 2012

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

To develop a stable chronic obstructive pulmonary disease (COPD) model in rats. Sprague-Dawley rats were treated with cigarette-smoke inhalation (CSI) for 12 weeks, repetitive bacterial infection (RBI) for 8 weeks, or the combination of the two (CCR) for 12 weeks and followed up for the additional 20 weeks. Tidal volume (V T ), peak expiratory flow (PEF) and 50% V T expiratory flow (EF 50 ), histological changes in the lungs, and levels of the cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-8, and IL-10 in serum and bronchial alveolar lavage fluid (BALF) were examined at intervals during the 32 week study period. The right ventricular hypertrophy index (RVHI) was also determined at the same times. V T , PEF, and EF 50 were decreased in rats with COPD compared to the control. The expression of TNF-α, IL-8 and IL-10 increased in both serum and BALF with a similar trend. Bronchiole and arteriole wall thickness and the degree of bronchiole stenosis and alveolar size increased in COPD rats. RVHI was reduced gradually following the treatment. All of these changes were more pronounced in the CCR-treatment group than in the other groups. Our results have shown that CSI or RBI alone can induce COPD in rats, but that the combination of CSI with RBI induces a stable COPD that has more similarity to complications seen in patients with COPD. This combination may therefore provide a more appropriate model for study of human COPD.Key words pulmonary disease; chronic obstructive; animal model; pulmonary function; histological change; right ventricular hypertrophy index Chronic obstructive pulmonary disease (COPD) has been defined as a preventable and treatable pathologic condition characterized by partially reversible airflow limitation, 1) and is a major cause of morbidity and mortality throughout the world.2) Its prevalence among the Chinese population aged 40 or older is 8.2%.3) Development of COPD is slow and progressive in humans, with occasional exacerbations caused by an inflammatory response to triggering substances such as noxious gases, 1) bacteria 4-6) or viruses. [7][8][9][10][11] Four abnormalities are present in chronic, stable COPD: emphysema, small airway remodeling, pulmonary hypertension, and chronic bronchitis.Tobacco smoking and bacterial infection are the most common and important risk factors for COPD, 1,12,13) and they have each been used to establish animal COPD models. [14][15][16] Animal models have also used other noxious gases [17][18][19] and Pneumocystis carinii infection 20) in COPD induction. Short term induction protocols (days) 17,21) have resulted in a pulmonary inflammatory infiltrate, increased mucus production, and pulmonary edema. Long term induction protocols (weeks or months) 15,[17][18][19] have produced, in addition to the inflammatory infiltrate, emphysema and pulmonary remodeling characterized by fibrosis, and thickened bronchiole and arterial walls. Problems with animal models are that most of them are of short duration and the COPD produced does not correspond to the late...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Rat Model for Stable Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke Inhalation and Repetitive Bacterial Infection

et al. 2012

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…This is a widely used method [4,12,13,[23][24][25][39][40][41][42][43][44][45][46][47], and can be viewed as modelling the inflammatory response to a single exposure to the components of cigarette smoke. A different model is chronic cigarette smoke exposure, which is often studied by animal models [48][49][50]. A disadvantage of this model is that animal and human biology may differ.…”

Section: Discussionmentioning

confidence: 99%

The effects of dexamethasone on cigarette smoke induced gene expression changes in COPD macrophages

Kent

Fox

Farrow

et al. 2010

International Immunopharmacology

View full text Add to dashboard Cite

“…Asthma in people is defined as "a [multiphenotypic] chronic inflammatory disorder of the airways associated with airway hyper-responsiveness [leading] to recurrent episodes of wheezing, breathlessness, chest tightness, coughing, [and] airflow obstruction often reversible with or without treatment" [124][125][126]. Asthma affects more than 10% of the North American population with the age of onset, pathophysiology, and response to treatment extremely variable [127,128].…”

Section: Asthmamentioning

confidence: 99%

“…The canine model has also been used as animal model for COPD in people. Although, no as much research as in asthma has been involved using the canine model, three model systems have been identified in dogs: inhalation of cigarette smoke, exposure to SO2 gas and intratracheal or aerosolization of proteolytic enzymes [125].…”

Section: Asthmamentioning

confidence: 99%

Animal Models of Allergic Diseases

Santoro

Marsella

2014

Veterinary Sciences

View full text Add to dashboard Cite

Allergic diseases have great impact on the quality of life of both people and domestic animals. They are increasing in prevalence in both animals and humans, possibly due to the changed lifestyle conditions and the decreased exposure to beneficial microorganisms. Dogs, in particular, suffer from environmental skin allergies and develop a clinical presentation which is very similar to the one of children with eczema. Thus, dogs are a very useful species to improve our understanding on the mechanisms involved in people's allergies and a natural model to study eczema. Animal models are frequently used to elucidate mechanisms of disease and to control for confounding factors which are present in studies with patients with spontaneously occurring disease and to test new therapies that can be beneficial in both species. It has been found that drugs useful in one species can also have benefits in other species highlighting the importance of a comprehensive understanding of diseases across species and the value of comparative studies. The purpose of the current article is to review allergic diseases across species and to focus on how these diseases compare to the counterpart in people.

show abstract

Canine models of asthma and COPD

Cited by 34 publications

References 125 publications

A Rat Model for Stable Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke Inhalation and Repetitive Bacterial Infection

A Rat Model for Stable Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke Inhalation and Repetitive Bacterial Infection

The effects of dexamethasone on cigarette smoke induced gene expression changes in COPD macrophages

Animal Models of Allergic Diseases

Contact Info

Product

Resources

About