Canine mucosal leishmaniasis

Font, Artur; Roura, Xavier; Fondevila, Dolors; Jm, Closa; Mascort, Joan; Ferrer, L.

doi:10.5326/15473317-32-2-131

Cited by 39 publications

(44 citation statements)

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“…Dogs infected with L. infantum can present rare or atypical forms of leishmaniosis [4]. These include a few reported cases of single [5,6] or multiple tongue nodules [7,8] and ulcers of the lingual mucosa [4,9]. …”

Section: Resultsmentioning

confidence: 99%

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Tongue nodules in canine leishmaniosis — a case report

et al. 2012

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BackgroundCanine leishmaniosis (CanL) caused by Leishmania infantum is an endemic zoonosis in southern European countries. Infected dogs can present rare or atypical forms of the disease and diagnosis can be challenging. The present report describes a case of tongue nodules in a 3-year-old neutered female Labrador Retriever dog with leishmaniosis.FindingsA fine needle aspiration of the lingual nodules revealed amastigote forms of Leishmania inside macrophages. Differential diagnosis ruled out neoplasia, calcinosis circumscripta, solar glossitis, vasculitis, amyloidosis, eosinophilic granulomas, chemical and electrical burns, uremic glossitis and autoimmune diseases. Combined therapy with antimoniate meglumine and allopurinol for 30 days resulted in the normalization of hematological and biochemical parameters. Two months after diagnosis and the beginning of treatment, a mild inflammatory infiltrate was observed by histopathology, but an anti-Leishmania immunofluorescence antibody test (IFAT) was negative as well as a PCR on both tongue lesions and a bone marrow aspirate. Seven months after diagnosis, the dog’s general condition appeared good, there were no tongue lesions and a new IFAT was negative. Fifteen months after diagnosis this clinically favourable outcome continued.ConclusionsThe dog could have suffered a relapsing episode of CanL, but a new systemic or local infection cannot be excluded. Regular clinical re-evaluation should be maintained, as a future relapse can potentially occur. In conclusion, CanL should be considered in the differential diagnosis of nodular glossitis in dogs.

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Section: Resultsmentioning

confidence: 99%

“…The first reference of tongue lesions in CanL was published by Font et al , who described a Leishmania -infected dog with proliferative lesions on the tongue and oral cavity mucosa [5]. Saari et al reported a 7-year-old male mongrel dog with a nodule protruding on the ventral surface of the tongue [6].…”

Section: Resultsmentioning

confidence: 99%

Tongue nodules in canine leishmaniosis — a case report

et al. 2012

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“…Laboratory evidence of CKD can be present in approximately 50% of dogs with leishmaniasis. 4,5 Moreover, histopathologic evidence of nephropathy occurs in 100% of dogs with leishmaniasis. [6][7][8] Initially, infected dogs have moderate to severe proteinuria without azotemia.…”

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confidence: 99%

“…As glomerular disease progresses, tubulointerstitial lesions, azotemia, and ultimately, end-stage renal failure develop. 4,9 Early recognition of a kidney dysfunction allows appropriate therapeutics and, potentially, a better prognosis. Evaluation of kidney function at the early stages of CKD is complicated, because the techniques most commonly used in the clinical setting (blood urea nitrogen and serum creatinine [SCr] concentration) are useful only when a severe reduction of the renal functional mass has occured.…”

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confidence: 99%

Glomerular Filtration Rate in Dogs with Leishmaniasis and Chronic Kidney Disease

Cortadellas

Palacio

Talavera

et al. 2008

Veterinary Internal Medicne

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Background: Glomerular filtration rate (GFR) measurement is an indicator of kidney function. However, its usefulness in dogs at early stages of spontaneous chronic kidney disease (CKD) of glomerular origin, where routine laboratory techniques are not sufficiently sensitive, remains unproved. Hypothesis: That GFR is reduced in proteinuric nonazotemic or mildly azotemic dogs with CKD secondary to leishmaniasis. Animals: Twenty‐six dogs with CKD secondary to leishmaniasis and 10 healthy dogs (control group). Methods: CBC, serum biochemistry, and urinalysis (microalbuminuria and urine protein/creatinine ratio [UPC]) were performed in all dogs. GFR was calculated by measuring exogenous creatinine clearance. Based on degree of proteinuria and serum creatinine concentration (SCr), dogs were classified as group A (control; n = 10): UPC < 0.2, SCr < 1.4 mg/dL; group B (n = 8): UPC, 0.2–0.5, SCr < 1.4 mg/dL; group C (n = 10): UPC > 0.5, SCr < 1.4 mg/dL; group D (n = 5): SCr, 1.4–2 mg/dL; group E (n = 3): SCr > 2 mg/dL. Results: GFR (mL/kg/min) was 3.9 ± 0.29, 4.4 ± 0.74, 4.5 ± 1.44, 2.8 ± 0.97, and 1.5 ± 0.43 for groups A, B, C, D, and E, respectively. Eleven dogs (1 from group B, 3 from group C, 4 from group D, and all 3 dogs from group E) had an abnormally low GFR. Four dogs from group B and 5 dogs from group C had a GFR above the upper reference range (>4.5 mL/min/kg). Conclusion and Clinical Relevance: Some proteinuric nonazotemic or mildly azotemic dogs with leishmaniasis have low GFR, but glomerular hyperfiltration occurs in other dogs.

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“…Microscopic examination of the scarification specimens of the lesions showed the presence of protozoa, either free or included into the histiocytes. These lesions may be secondary to the first localization of the parasite in the organism (Font et al, 1996). Some authors have reported the presence of proliferative lesions as nodules or ulcers on the tongue mucosae, lower surface included, and on the oral and nasal cavities, caused by the action of the parasite (Lamothe, 1997).…”

Section: Introductionmentioning

confidence: 98%