Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs

Schueler, Rita; White, Gillian; Schueler, Robert; Steiner, Jörg M.; Wassef, Adel

doi:10.1111/jsap.12818

Cited by 20 publications

(43 citation statements)

References 40 publications

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“…Therefore, the authors recommend that a quantitative pancreatic lipase assay should be performed in addition to an AUS in all dogs being assessed for pancreatitis. One potential explanation for the lower correlation between UPASS and Spec cPL than between UPASS and CDx is that primary nonpancreatic diseases and steroid treatment have been associated with an above reference interval Spec cPL concentration, although the clinical relevance of these increases are often unknown …”

Section: Discussionmentioning

confidence: 99%

“…explanation for the lower correlation between UPASS and Spec cPL than between UPASS and CDx is that primary nonpancreatic diseases and steroid treatment have been associated with an above reference interval Spec cPL concentration, although the clinical relevance of these increases are often unknown. 21,[26][27][28][29][30][31][32] When evaluating individual components of the UPASS, this study . This is likely due to the fact that diseases other than pancreatitis cause pancreatic edema, including hypoalbuminemia and portal hypertension.…”

Section: Discussionmentioning

confidence: 99%

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Association between abdominal ultrasound findings, the specific canine pancreatic lipase assay, clinical severity indices, and clinical diagnosis in dogs with pancreatitis

Cridge

Sullivant

Wills

et al. 2020

Veterinary Internal Medicne

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Background A clinical diagnosis (CDx) of pancreatitis includes evaluation of clinical signs, abdominal ultrasound (AUS), and pancreatic lipase. However, practitioners are using AUS to diagnose pancreatitis and are using AUS severity to guide decisions. The validity of this is unknown. Objectives To determine whether (1) there is a correlation between AUS, specific canine pancreatic lipase (Spec cPL) assay, and CDx; (2) individual AUS abnormalities correlate more closely with CDx than others; (3) AUS severity mirrors clinical severity indices; (4) changes in AUS can be used as a marker for changes in Spec cPL or CDx; and (5) the sensitivity and specificity of AUS for pancreatitis. Animals One hundred fifty‐seven dogs. Methods In this retrospective case study, inclusion criteria were signs of gastrointestinal, pancreatic disease, or both, in addition to having a Spec cPL and AUS performed within 30 hours. Information extracted from the records included bloodwork, Spec cPL, AUS images/clips, and severity of ultrasonographic findings. Results AUS was weakly correlated with Spec cPL (rs = .0178, P = .03) and moderately correlated with CDx (rs = .379, P = <.001). Pancreatic size (rs = .285, P = <.001), echogenicity (rs = .365, P = <.001), and mesenteric echogenicity (rs = .343, P = <.001) were correlated with CDx. Change in AUS was not correlated with Spec cPL or CDx changes. When pancreatic enlargement, echogenicity, or altered mesenteric echogenicity were required for a diagnosis, the sensitivity and specificity were 89% (95% confidence interval [CI] 71.8, 97.7) and 43% (95% CI 34.0, 51.6). When all 3 criteria were required, the sensitivity and specificity were 43% (95% CI 24.5, 62.8) and 92% (95% CI 85.3, 95.7). Conclusions AUS should not be used in isolation to diagnose pancreatitis and is a poor indicator of severity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between abdominal ultrasound findings, the specific canine pancreatic lipase assay, clinical severity indices, and clinical diagnosis in dogs with pancreatitis

Cridge

Sullivant

Wills

et al. 2020

Veterinary Internal Medicne

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“…It was therefore considered reasonable to use veterinary-diagnosed animals as Cases even if no tests had been performed beyond clinical examination. It should be borne in mind that animals presenting with pain but with no ataxia or paresis have a less certain diagnosis without advanced imaging, as they may be difficult to differentiate from those with pancreatitis [ 65 ] or other painful conditions. However, only 21 (6.7%) of the 313 animals diagnosed with IVDH presented with pain or discomfort and with no other reported clinical signs (Table 6 ).…”

Section: Discussionmentioning

confidence: 99%

Neuter status as a risk factor for canine intervertebral disc herniation (IVDH) in dachshunds: a retrospective cohort study

Dorn¹,

Seath²

2018

Canine Genet Epidemiol

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BackgroundIntervertebral disc herniation (IVDH) involves displacement of the intervertebral disc secondary to disc degeneration and is extremely common in dachshunds. Clinical signs include pain with or without paresis or paralysis. Mortality rate is high and some cases are left with permanent disability even after treatment. Aims of this study were twofold: Firstly, to investigate whether neutering, i.e. gonadectomy, is associated with increased risk of IVDH in dachshunds, and secondly to investigate whether age of neutering alters risk of IVDH in this breed.Information was obtained for 1964 dachshunds from the owner survey, “Dachslife 2015”. For dachshunds that were ≥ 3 years and < 10 years old at the time of the survey (1073 individuals) incidence of IVDH was compared between early-neutered (< 12 months), late-neutered (> 12 months) and entire animals of each gender.ResultsNeutered females were at significantly higher risk of IVDH than entire females (risk ratio 1.81, 95% CI 1.28–2.54). For males, incidence of IVDH in neutered as compared with entire dachshunds was increased but this difference was not quite statistically significant (risk ratio 1.38, 95% CI 0.96–1.99).For both genders, this study demonstrated significantly increased risk of IVDH in early-neutered dachshunds (before 12 months old) as compared with those neutered late (after 12 months old). For early neutered males, risk ratio was 1.54 (95% CI 1.07–2.22). For early-neutered females, risk ratio was 2.12 (95% CI 1.44–3.11).ConclusionResults from this retrospective study suggest that gonadectomy, especially if performed before 12 months old, increases risk of IVDH in this breed. Decisions regarding neutering should be made on an individual basis, taking a range of pros and cons into account. Considering the high prevalence, morbidity and mortality of IVDH in dachshunds, increased IVDH risk associated with neutering is a key factor to consider in deciding whether and when to neuter.

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“…Congestive heart failure, hyperadrenocorticism, intervertebral disc disease, and immune-mediated hemolytic anemia can cause Spec cPL increases in the absence of clinical signs consistent with pancreatitis. 7,16,23,32 Also, Spec cPL may indicate a “false-positive” diagnosis of pancreatitis in up to 23% of dogs with acute abdominal signs in which another disease is diagnosed. 8 Increases in Spec cPL in the absence of clinical signs compatible with pancreatitis, or with a non-pancreatic disease explaining the clinical signs, might reflect subclinical pancreatic inflammation, edema, or hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Increased canine pancreatic lipase immunoreactivity (cPLI) and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR) lipase in dogs with evidence of portal hypertension and normal pancreatic histology: a pilot study

et al. 2021

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The clinical presentations of both liver disease and pancreatitis are nonspecific and overlapping, which may cause difficulty in diagnosis. In our retrospective pilot study, we assessed whether dogs with evidence of portal hypertension and absence of pancreatitis on pancreatic histology have increases in canine pancreatic lipase immunoreactivity (cPLI) and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR) lipase. We included dogs that had been presented between 2008 and 2019 if they had normal pancreatic histology, histologically confirmed hepatopathy, and if canine pancreas-specific lipase (Spec cPL; Idexx) or DGGR lipase had been measured. Only dogs with portal hypertension were included. Six dogs fulfilled the inclusion criteria. Four of 6 and 2 of 6 dogs had Spec cPL and DGGR lipase exceeding the upper reference limit, respectively. From the 4 dogs with increased Spec cPL, 2 had concentrations of 200–400 µg/L and 2 had concentrations ≥ 400 µg/L. Our results suggest that canine portal hypertension might lead to increased Spec cPL and DGGR lipase values in the absence of pancreatitis on histology. Until more evidence in a larger number of dogs with portal hypertension is available, both tests should be interpreted cautiously in the presence of portal hypertension.

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Canine pancreatic lipase immunoreactivity concentrations associated with intervertebral disc disease in 84 dogs

Abstract: These results suggest that serum canine pancreatic lipase immunoreactivity concentrations are significantly elevated in dogs with intervertebral disc herniation.

Cited by 20 publications

References 40 publications

Association between abdominal ultrasound findings, the specific canine pancreatic lipase assay, clinical severity indices, and clinical diagnosis in dogs with pancreatitis

Association between abdominal ultrasound findings, the specific canine pancreatic lipase assay, clinical severity indices, and clinical diagnosis in dogs with pancreatitis

Neuter status as a risk factor for canine intervertebral disc herniation (IVDH) in dachshunds: a retrospective cohort study

Increased canine pancreatic lipase immunoreactivity (cPLI) and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR) lipase in dogs with evidence of portal hypertension and normal pancreatic histology: a pilot study

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