Canine Pancreatic‐Specific Lipase Concentrations in Dogs with Heart Failure and Chronic Mitral Valvular Insufficiency

Abstract

BackgroundChronic mitral valvular insufficiency (CMVI) in dogs is very common and might cause clinical signs of congestion and poor tissue perfusion.HypothesisPoor tissue perfusion from CMVI causes pancreatitis in dogs, as indicated by serum pancreatic lipase concentrations.AnimalsSixty‐two client‐owned dogs consisting of 40 dogs with different stages of heart failure from CMVI and 22 age‐matched healthy dogs, based on full cardiac exam and routine laboratory tests.MethodsProspective, controlled, observational study. Serum canine pancreatic lipase immunoreactivity (cPLI) concentrations were determined by quantitative cPLI test in healthy and CMVI groups.ResultsSerum cPLI concentrations were 54.0 μg/L (IQR: 38.0–78.8 μg/L) in control, 55.0 μg/L (IQR: 38.3–88.8 μg/L) in ISACHC I, 115.0 μg/L (IQR: 45.0–179.0 μg/L) in ISACHC II and 223.0 μg/L (IQR: 119.5–817.5 μg/L) in ISACHC III. Close correlation to serum cPLI concentration was found in the left atrial to aorta (LA/Ao) ratio (r = 0.597; P = .000) and the severity of heart failure (r = 0.530; P = .000).Conclusions and Clinical ImportanceThis study found CMVI is associated with pancreatic injury in congestive heart failure caused by CMVI. Therefore, periodic monitoring on cPLI could be useful in monitoring dogs in heart failure.

Association between abdominal ultrasound findings, the specific canine pancreatic lipase assay, clinical severity indices, and clinical diagnosis in dogs with pancreatitis

“…Therefore, the authors recommend that a quantitative pancreatic lipase assay should be performed in addition to an AUS in all dogs being assessed for pancreatitis. One potential explanation for the lower correlation between UPASS and Spec cPL than between UPASS and CDx is that primary nonpancreatic diseases and steroid treatment have been associated with an above reference interval Spec cPL concentration, although the clinical relevance of these increases are often unknown …”

“…explanation for the lower correlation between UPASS and Spec cPL than between UPASS and CDx is that primary nonpancreatic diseases and steroid treatment have been associated with an above reference interval Spec cPL concentration, although the clinical relevance of these increases are often unknown. 21,[26][27][28][29][30][31][32] When evaluating individual components of the UPASS, this study . This is likely due to the fact that diseases other than pancreatitis cause pancreatic edema, including hypoalbuminemia and portal hypertension.…”

Chronic Mitral Valve Insufficiency in Dogs: Recent Advances in Diagnosis and Treatment

“…Also, close correlation of serum cPLI concentration was found in the left atrial to aorta (LA/Ao) ratio (r = 0.597; P = 0.000) and the severity of heart failure (r = 0.530; P = 0.000). This study found that the CMVI is associated with pancreatic injury in congestive heart failure due to the CMVI [27].…”

“…Poor tissue perfusion from CMVI causes pancreatitis in dogs, as indicated by serum pancreatic lipase concentrations. One recent study has evaluated the prevalence of pancreatitis in 62 client-owned dogs consisting of 40 dogs with different stages of heart failure from CMVI and 22 age-matched healthy dogs [27]. Serum canine pancreatic lipase immunoreactivity (cPLI) concentrations were determined by quantitative cPLI test in healthy and CMVI groups in this study.…”

“…One recent study found that CMVI is associated with pancreatic injury in congestive heart failure caused by CMVI. Therefore, periodic monitoring on cPLI could be useful in monitoring dogs in heart failure [27].…”