Canine serum C‐reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery

Kjelgaard‐Hansen, Mads; Strøm, Henriette; Mikkelsen, Lars Friis; Eriksen, Thomas; Jensen, A. L.; Luntang-Jensen, Michael

doi:10.1111/vcp.12063

Cited by 41 publications

(59 citation statements)

References 13 publications

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“…The acute phase response observed in the dogs of this study consisted of increased CRP and SAA postsurgery. These results were similar to those described in previous reports on APP after surgical trauma . Repeated measurements of CRP and SAA were useful in monitoring the short‐term inflammatory process induced by the nephrectomy that was associated with increases in serum concentration of both APPs.…”

Section: Discussionmentioning

confidence: 99%

Acute phase proteins in dogs naturally infected with the Giant Kidney Worm (Dioctophyme renale)

Schmidt

Kjelgaard‐Hansen

Thomas

et al. 2016

Veterinary Clinical Pathol

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Section: Discussionmentioning

confidence: 99%

Acute phase proteins in dogs naturally infected with the Giant Kidney Worm (Dioctophyme renale)

Schmidt

Kjelgaard‐Hansen

Thomas

et al. 2016

Veterinary Clinical Pathol

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“…SAA causes the detoxification of endotoxin and the habitation of proliferation; also, it is an indicator of infection (Murata, Shimada, & Yoshioka, ). Likewise, the acute phase protein can be used as a marker of the inflammatory stimulus in soft tissue surgery (Kjelgaard‐Hansen et al, ).…”

Section: Discussionmentioning

confidence: 99%

Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH‐induced dogs with an anti‐proliferative agent called tadalafil

Dearakhshandeh

Mogheiseh

Nazifi

et al. 2019

Vet Pharm & Therapeutics

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Background Finding a medical treatment which can combat cell proliferation and relax smooth muscles in canine benign prostatic hyperplasia (BPH) appears to be imperative. Aims This study aimed to evaluate the oxidative stress and inflammatory proteins following the treatment of dogs induced for BPH with an anti‐proliferative agent called tadalafil. Materials and Methods Twenty‐five adult intact male dogs were randomly designated into five groups (n = 5): Control group was not induced for BPH and not treated with tadalafil; dogs induced for BPH by testosterone enanthate and estradiol benzoate and treated with tadalafil (5 mg/day P.O.); dogs which received tadalafil (5 mg/day P.O.); dogs induced for BPH and treated with castration; and dogs induced for BPH. Oxidative stress factors (glutathione peroxidase [GPX], superoxide dismutase [SOD], catalase) and inflammatory proteins (haptoglobin, serum amyloid A [SAA], malondialdehyde [MDA]) were measured in the blood serum for four sequential weeks. Results Glutathione peroxidase and SOD serum levels declined in dogs in the BPH‐induced group compared to those in the control group. Those levels diminished in BPH‐induced castrated and tadalafil‐treated groups. The changes in the GPX and SOD serum concentrations were not significant between the BPH‐induced castrated group and BPH‐induced tadalafil‐treated group. Moreover, MDA concentration increased slightly in groups with BPH and groups which were castrated. Generally, however, there were no significant differences in the MDA serum concentrations between other groups. Haptoglobin and SAA concentrations increased in BPH‐castrated group. Also, the differences in haptoglobin and SAA were not significant between the groups. Conclusion Tadalafil could not control oxidative stress and inflammatory mediators which happened during BPH in dogs.

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“…Measurement of circulating concentrations of CRP in dogs has been shown to be clinically useful for diagnosing and monitoring systemic inflammatory diseases [15, 16]. C-reactive protein has the advantages of being an objective, quantitative marker of inflammation [17] that is not biased by treatment with non-steroidal anti-inflammatory drugs (NSAID) [18–20] or glucocorticoids [21]. This is in contrast to other markers of systemic inflammation such as fever and evaluation of the leukogram [21, 22].…”

Section: Introductionmentioning

confidence: 99%

Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs

et al. 2016

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BackgroundIn a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with suppurative arthritis and osteoarthritis (OA). Furthermore, the concentrations of serum and synovial fluid interleukin (IL) 6 concentrations were measured in dogs with joint disease and in healthy dogs, and were correlated to serum CRP concentrations.MethodsDogs with joint pain were enrolled prospectively and were classified to have suppurative arthritis or OA based on synovial fluid analysis and radiographic/arthroscopic findings. Healthy Beagles were enrolled as a comparative group. CRP and IL-6 concentrations were measured with canine-specific immunoassays. The performance of CRP concentration in discriminating between dogs with suppurative arthritis and OA was evaluated using a previously established clinical decision limit for CRP (20 mg/l), and by receiver operator characteristic (ROC) curve and logistic regression analysis. Comparisons of CRP and IL-6 concentrations between groups were performed using t-tests, and correlations by Spearman rank correlation coefficients.ResultsSamples were obtained from 31 dogs with suppurative arthritis, 34 dogs with OA, and 17 healthy dogs. Sixty-two out of 65 dogs with joint disease were correctly classified using the clinical decision limit for CRP. Evaluation of ROC curve and regression analysis indicated that serum CRP concentrations could discriminate between suppurative arthritis and OA. Dogs with suppurative arthritis had higher serum CRP and serum and synovial fluid IL-6 concentrations compared to dogs with OA (p < 0.001). Dogs with OA had higher synovial fluid IL-6 concentrations (p < 0.001), but not higher serum CRP (p = 0.29) or serum IL-6 (p = 0.07) concentrations, compared to healthy dogs. There was a positive correlation between synovial fluid IL-6 and serum CRP concentrations (rs = 0.733, p < 0.001), and between serum IL-6 and serum CRP concentrations (rs = 0.729, p < 0.001).ConclusionCRP concentration was found to discriminate well between dogs with suppurative arthritis and OA.

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Canine serum C‐reactive protein as a quantitative marker of the inflammatory stimulus of aseptic elective soft tissue surgery

Abstract: The CRP response varied according to the degree of surgical trauma on 3 standardized levels, thus supporting the use of canine serum concentrations of CRP as an inflammatory activity indicator and monitoring marker.

Cited by 41 publications

References 13 publications

Acute phase proteins in dogs naturally infected with the Giant Kidney Worm (Dioctophyme renale)

Acute phase proteins in dogs naturally infected with the Giant Kidney Worm (Dioctophyme renale)

Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH‐induced dogs with an anti‐proliferative agent called tadalafil

Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs

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