Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits

Jha, Saurabh Kumar; Nelson, Vinod Kumar; Suryadevara, Punna Rao; Panda, Siva Prasad; Pullaiah, Chitikela P.; Nuli, Mohana Vamsi; Kamal, Mehnaz; Imran, Mohd; Ausali, Saijyothi; Abomughaid, Mosleh Mohammad; Srivastava, Rashi; Deka, Rahul; Pritam, Pingal; Gupta, Neha; Shyam, Harishankar; Singh, Indrakant K.; Pandey, Bindhy Wasini; Dewanjee, Saikat; Jha, Niraj Kumar; Jafari, Seid Mahdi

doi:10.1016/j.arr.2024.102386

Ageing Research Reviews

2024

DOI: 10.1016/j.arr.2024.102386

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Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits

Saurabh Kumar Jha,

Vinod Kumar Nelson,

Punna Rao Suryadevara

et al.

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Cited by 4 publications

References 152 publications

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Advanced electrochemical detection methodologies for assessing neuroactive substance variability induced by environmental pollutants exposure

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Environmental Technology & Innovation

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Advanced electrochemical detection methodologies for assessing neuroactive substance variability induced by environmental pollutants exposure

Cao,

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Cannabis for medicine and food: A benefit vs risk critical appraisal

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South African Journal of Botany

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New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment

Angelova,

Stoyanov,

Simeonova

2024

Molecules

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Alzheimer’s disease (AD) involves a complex pathophysiology with multiple interconnected subpathologies, including protein aggregation, impaired neurotransmission, oxidative stress, and microglia-mediated neuroinflammation. Current treatments, which generally target a single subpathology, have failed to modify the disease’s progression, providing only temporary symptom relief. Multi-target drugs (MTDs) address several subpathologies, including impaired aggregation of pathological proteins. In this review, we cover hybrid molecules published between 2014 and 2024. We offer an overview of the strategies employed in drug design and approaches that have led to notable improvements and reduced hepatotoxicity. Our aim is to offer insights into the potential development of new Alzheimer’s disease drugs. This overview highlights the potential of multi-target drugs featuring heterocycles with N-benzylpiperidine fragments and natural compounds in improving Alzheimer’s disease treatment.

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Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits

Cited by 4 publications

References 152 publications

Advanced electrochemical detection methodologies for assessing neuroactive substance variability induced by environmental pollutants exposure

Advanced electrochemical detection methodologies for assessing neuroactive substance variability induced by environmental pollutants exposure

Cannabis for medicine and food: A benefit vs risk critical appraisal

New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment

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