Cannabidiol as a personalized treatment for anxiety: clinical cases in Mexico

Abstract

Anxiety-related disorders are one of the most common mental health issues worldwide. Mexico has reported an increase in the prevalence of these ailments secondary to the confinement derived from the COVID-19 pandemic. Given the limitations of commonly used treatments for these disorders, a need arises to develop new pharmacological treatments for these patients. This paper has the primary objective of evaluating the efficacy and safety of cannabidiol isolate in drug compounding used as a personalized treatment in patients with anxiety disorders through the presentation of four clinical cases.

A eficácia do canabidiol no tratamento dos transtornos de ansiedade: Uma revisão integrativa de literatura

“…Isso pode ser atribuído a variáveis como o uso concomitante de terapias cognitivas, medicação psiquiátrica de rotina, o uso de suplementos nutricionais e o ajuste de dose realizado em todos os casos até a observação de efeitos benéficos em cada paciente individual. Esses resultados indicam a importância de uma abordagem integrativa ao tratamento, incluindo terapias adicionais e medicações, para obter resultados mais eficazes em pacientes com transtornos de ansiedade e insônia (Ortiz Rios et al, 2022).…”

Cannabidiol in sports: insights on how CBD could improve performance and recovery

“…CBD’s effect on GABA receptors can promote deeper, more comfortable sleep. Furthermore, CBD’s ability to relieve anxiety and stress, which are significant causes of sleep disruption, indirectly supports greater sleep quality ( Blessing et al, 2015 ; Moltke and Hindocha, 2021 ; Ortiz Rios et al, 2022 ). CBD provides a biological foundation for its action via modifying endocannabinoid system signalling, increasing adenosine effects, and regulating GABAergic neurotransmission ( Zou & Kumar, 2018 ; Yarar, 2020 ; Martinez Naya et al, 2023 ).…”

The Antioxidant and Neuroprotective Potential of Leaves and Inflorescences Extracts of Selected Hemp Varieties Obtained with scCO2

“…The confirmed pharmacological activity of cannabinoids includes reducing muscle spasticity and spasms in patients with multiple sclerosis [11], reducing neuropathic pain [12], migraines [13], reducing the number of seizures in epilepsy [14,15], relieving the effects of irritable bowel syndrome [16], Crohn's disease symptoms [17], depression [18], and reducing anxiety and its related symptoms (such as insomnia) [19,20]. Recent scientific reports indicate a possibility of alleviating the pain associated with endometriosis [21], and vulvodynia [22], and enhancing the quality of life for patients and to enable them to engage more effectively with their surroundings.…”