Cannabidiol attenuates methamphetamine-induced conditioned place preference in male rats and viability in PC12 cells through the Sigma1R/AKT/GSK3β/CREB signaling pathway

Identification of the circRNA–miRNA–mRNA network for treating methamphetamine‐induced relapse and behavioral sensitization with cannabidiol

“…In the present study, repeated METH administration successfully induced a significant CPP (using a biased place conditioning paradigm) in male mice, consistent with our previous findings in male rats 9,10 . However, the duration of extinction days varies in METH‐induced CPP studies, ranging from 5 to 7 days 35–37 to long periods 11,38 .…”

“…For instance, administering CBD (40 and 80 mg/kg) for 10 consecutive days during extinction phase facilitated CPP extinction in rats. 10 However, in the present study, mice treated with CBD (20 and 40 mg/kg) for extended periods during the extinction phase did not exhibit such a facilitating effect. The method of CBD administration also contributes to this discrepancy.…”

“…11,38 In our previous study, a 10-day extinction period failed to extinguish the METH-induced CPP. 10 As reported in a previous study, the 11-day extinction had no significant impact on METH-induced CPP. 39 In this study, a significant extinction of METH-induced CPP was observed after a 14-day extinction period but not after a 7-day extinction period.…”

“…In recent years, CBD has been studied in the field of substance use disorders, such as METH addiction. Our previous study demonstrated that administration of CBD (40 and 80 mg/kg, but not 10 and 20 mg/kg) in the acquisition or extinction phase of CPP effectively reduced METH‐induced CPP and facilitated CPP extinction in male rats 9,10 . In this study, we further explored the effects of CBD (20 and 40 mg/kg) on METH‐induced CPP reinstatement and behavioral sensitization in male mice.…”

“…Our previous study demonstrated that administration of CBD (40 and 80 mg/kg, but not 10 and 20 mg/kg) in the acquisition or extinction phase of CPP effectively reduced METH-induced CPP and facilitated CPP extinction in male rats. 9,10 In this study, we further explored the effects of CBD (20 and 40 mg/kg) on METH-induced CPP reinstatement and behavioral sensitization in male mice. We found that repeated administration of CBD (40 mg/kg, but not 20 mg/kg) during the METH withdrawal period significantly inhibits METH-induced CPP reinstatement and behavioral sensitization in mice.…”