Cannabidiol exerts antipyretic effects by downmodulating inflammatory mediators in LPS-induced fever

Andres, Emilly S.S.; Passaglia, Patrícia; Santos, Wanderson S.; Trajano, Isis P.; Soriano, Renato Nery; Marques, Lucas Miranda; Nascimento, Glauce C.; Del-Bel, Elaine; Branco, Luiz G.S.

doi:10.1016/j.pnpbp.2024.111178

Progress in Neuro-Psychopharmacology and Biological Psychiatry

2025

DOI: 10.1016/j.pnpbp.2024.111178

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Cannabidiol exerts antipyretic effects by downmodulating inflammatory mediators in LPS-induced fever

Emilly S.S. Andres,

Patrícia Passaglia,

Wanderson S. Santos

et al.

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Impact of Periodontal Lipopolysaccharides on Systemic Health: Mechanisms, Clinical Implications, and Future Directions

Santos,

Solon,

Branco

2024

Molecular Oral Microbiology

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Periodontal diseases, particularly periodontitis, are complex inflammatory conditions caused by interactions between oral microbiota and the host immune response. Lipopolysaccharides (LPSs) from Gram‐negative bacteria like Tannerella forsythia, Treponema denticola, and Porphyromonas gingivalis are key in pathogenesis. This review examines how LPS impacts systemic health through direct invasion, compromised oral barriers, increased vascular permeability, and immune cell transport. LPS triggers inflammation in periodontal tissues, leading to tissue destruction and disease progression. In the bloodstream, LPS contributes to conditions, such as cardiovascular diseases, diabetes, respiratory diseases, and rheumatoid arthritis. Current treatments include mechanical debridement, antibiotics, antimicrobial mouthwashes, and anti‐inflammatory therapies. Despite progress, gaps remain in understanding the molecular mechanisms of LPS in systemic diseases. Future research should focus on longitudinal studies, the gut–oral axis, biomarkers for early detection, and the lymphatic system's role in LPS dissemination. Maintaining periodontal health is crucial for overall systemic well‐being.

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Impact of Periodontal Lipopolysaccharides on Systemic Health: Mechanisms, Clinical Implications, and Future Directions

Santos,

Solon,

Branco

2024

Molecular Oral Microbiology

View full text Add to dashboard Cite

show abstract

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Cannabidiol exerts antipyretic effects by downmodulating inflammatory mediators in LPS-induced fever

Cited by 1 publication

References 28 publications

Impact of Periodontal Lipopolysaccharides on Systemic Health: Mechanisms, Clinical Implications, and Future Directions

Impact of Periodontal Lipopolysaccharides on Systemic Health: Mechanisms, Clinical Implications, and Future Directions

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