Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

Oláh, Attila; Tóth, Balázs István; Borbíró, István; Sugawara, Koji; Szöllősi, Attila Gábor; Czifra, Gabriella; Pál, Balázs; Ambrus, Lídia; Kloepper, Jennifer E.; Camera, Emanuela; Ludovici, Matteo; Picardo, Mauro; Voets, Thomas; Zouboulis, Christos C.; Paus, Ralf; Bı́ró, Tamás

doi:10.1172/jci64628

Cited by 236 publications

(269 citation statements)

References 76 publications

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“…“Tonic” activation of CB 1 was shown to keep maturation and degranulation of human skin mast cells under constitutive control, and the “pro-inflammatory” degranulation of mast cells was found to be prevented by AEA or CB 1 agonists [146]. Of further importance, the prototypic non-psychoactive phytocannabinoid cannabidiol – by modulating a complex signaling network involving TRPV4 ion channels, adenosine A2a receptors, and multiple downstream elements ( e.g ., P65-NFκB pathway, tribbles homolog 3) – exerted dramatic sebostatic ( i.e ., suppression of unwanted lipogenesis) and anti-inflammatory effects in a human cellular/organ culture model of acne vulgaris, the most prevalent human skin disease [147]. …”

Section: Skinmentioning

confidence: 99%

Endocannabinoid signaling at the periphery: 50 years after THC

Maccarrone

Bab

Bı́ró

et al. 2015

Trends in Pharmacological Sciences

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571

549

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Fifty years ago (in 1964) the psychoactive ingredient of Cannabis sativa, Δ9-tetrahydrocannabinol (THC), was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed endocannabinoids (eCBs), were discovered: N-arachidonoylethanolamine (anandamide, AEA) in 1992, and 2-arachidonoylglycerol (2-AG) in 1995. Since then, considerable research has shed light on the impact of eCBs on human health and disease, identifying an ensemble of proteins that bind, synthesize and degrade them, and that altogether form the eCB system. eCBs control basic biological processes, including cell-choice between survival and death, and progenitor/stem cell proliferation and differentiation. Not surprisingly, in the past two decades, eCBs have been recognized as key mediators of several aspects of human pathophysiology, and thus have emerged among the most widespread and versatile signaling molecules ever discovered. Here, some of the pioneers of this research field review the state-of-the-art of critical eCB functions in peripheral organs. Our community effort is aimed at establishing consensus views on the relevance of the peripheral eCB system for human health and disease pathogenesis, as well as to highlight emerging challenges and therapeutic hopes.

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Section: Skinmentioning

confidence: 99%

Endocannabinoid signaling at the periphery: 50 years after THC

Maccarrone

Bab

Bı́ró

et al. 2015

Trends in Pharmacological Sciences

Self Cite

571

549

View full text Add to dashboard Cite

show abstract

“…In animal models of inflammation, its effects are often blocked by adenosine receptor antagonists (122,126,482,515,519,534,559,640,725).…”

Section: Introduction: Cannabis and Cannabinoids Ancient Drugs Bementioning

confidence: 99%

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

Ligresti¹,

Petrocellis²,

Marzo³

2016

Physiological Reviews

377

337

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Apart from having been used and misused for at least four millennia for, among others, recreational and medicinal purposes, the cannabis plant and its most peculiar chemical components, the plant cannabinoids (phytocannabinoids), have the merit to have led humanity to discover one of the most intriguing and pleiotropic endogenous signaling systems, the endocannabinoid system (ECS). This review article aims to describe and critically discuss, in the most comprehensive possible manner, the multifaceted aspects of 1) the pharmacology and potential impact on mammalian physiology of all major phytocannabinoids, and not only of the most famous one ⌬ 9 -tetrahydrocannabinol, and 2) the adaptive prohomeostatic physiological, or maladaptive pathological, roles of the ECS in mammalian cells, tissues, and organs. In doing so, we have respected the chronological order of the milestones of the millennial route from medicinal/recreational cannabis to the ECS and beyond, as it is now clear that some of the early steps in this long path, which were originally neglected, are becoming important again. The emerging picture is rather complex, but still supports the belief that more important discoveries on human physiology, and new therapies, might come in the future from new knowledge in this field.

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“…A recent study by Olah et al showed that cannabidiol (CBD), a nonpsychotropic phytocannabinoid derived from Cannabis sativa might, in fact, improve acne vulgaris through a sebostatic mechanism, among others. [81]. The study found that CBD had antiproliferative effects on both keratinocytes and sebocytes, thus decreasing formation of comedones and production of sebum.…”

Section: Marijuana (Cannabis)mentioning

confidence: 92%

“…CBD also has antiinflammatory properties, owing to its inhibition of NF-κB signaling. Collectively, the effects exerted by CBD exemplify its pharmacologic potential in the treatment of acne vulgaris [81,84].…”

Section: Marijuana (Cannabis)mentioning

confidence: 99%

Dermatologic Signs and Symptoms of Substance Abuse

Raiker¹,

Aouthmany²

2016

J Clin Exp Dermatol Res

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Various substances of abuse are known to cause specific cutaneous manifestations. In this review, we highlight the cutaneous manifestations associated with the use of cocaine, heroin, marijuana, methamphetamine, alcohol, and anabolic steroids. Cutaneous signs of tanning addiction are also discussed, as tanning bed use is a particularly relevant and growing problem in Dermatology. We also provide examples of general signs of drug abuse, including stigmata of injection drug use, vascular complications, and infectious complications. This review aims to make clinicians more aware of these signs in order to better recognize substance abuse disorders and guide effective treatment.

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Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

Cited by 236 publications

References 76 publications

Endocannabinoid signaling at the periphery: 50 years after THC

Endocannabinoid signaling at the periphery: 50 years after THC

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

Dermatologic Signs and Symptoms of Substance Abuse

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