Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry

Bellocchio, Luigi; Patano, Assunta; Inchingolo, Alessio Danilo; Inchingolo, Francesco; Dipalma, Gianna; Isacco, Ciro Gargiulo; Ruvo, Elisabetta de; Rapone, Biagio; Mancini, Antonio; Lorusso, Felice; Marinelli, Grazia; Inchingolo, Angelo Michele

doi:10.3390/ijms24119693

Cited by 7 publications

(2 citation statements)

References 155 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The en bloc (full-thickness) excision of a skeletal segment with the interruption of its anatomical continuity is referred to as segmental resective surgery [39,44].…”

Section: Discussionmentioning

confidence: 99%

Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery

et al. 2023

Self Cite

View full text Add to dashboard Cite

Aims: Medication-related osteonecrosis of the jaw (MRONJ) is a drug-related adverse reaction characterized by bone destruction and necrosis in the jaw. This case series aims to evaluate the treatment approaches and outcomes in MRONJ patients. Materials and methods: The retrospective study was conducted at the Dental Unit of the University of Bari, Italy. Patients with MRONJ were treated and followed up for 60 months. The treatment approach involved piezosurgery and concentrated growth factor (CGF). Six clinical cases from this group are described in detail. Results: None of the patients showed recurrence of necrotic MRONJ lesions during the follow-up period. The surgical interventions, including bone resections and the application of CGF, resulted in successful mucosal healing and the prevention of disease progression. Conclusions: This study highlights the complexity of managing MRONJ and the importance of a multidisciplinary approach. Conservative treatment options and minimally invasive surgery have shown efficacy in controlling symptoms and improving patients’ quality of life. However, the optimal treatment approach remains a challenge, and further studies are needed to evaluate alternative therapies and resective surgery. A comprehensive preoperative evaluation and collaboration among dental, endocrinology, and oncology specialists are crucial for personalized and multidisciplinary management. Ongoing research efforts are necessary to explore new therapeutic modalities and improve our understanding of MRONJ management, providing better support to patients dealing with this complex condition.

show abstract

“…The en bloc (full-thickness) excision of a skeletal segment with the interruption of its anatomical continuity is referred to as segmental resective surgery [39,44].…”

Section: Discussionmentioning

confidence: 99%

Sixty-Month Follow Up of Clinical MRONJ Cases Treated with CGF and Piezosurgery

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Various studies have investigated various aspects of hemp, such as its components, biological activities and industrial applications. Hemp may have a therapeutic effect on the treatment of dental caries because of its antibacterial properties (Bellocchio et al, 2023). Hemp-containing mouthwashes, when applied to dental plaque, showed bacterial inhibition with the same efficacy as chlorhexidine, which is a common agent for disinfection.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Remineralization Effect of Hemp-Containing Toothpaste

ALKAN,

TAĞTEKİN,

KORKMAZ

et al. 2023

ERD

View full text Add to dashboard Cite

Objective:The study aimed to evaluate the remineralizing effect of hemp on initial enamel caries lesions.Materials and methods: Initial caries lesions were created on twenty-eight intact enamel samples with demineralization solution (pH=4.5) in a shaking incubator for 72 hours at 37⁰C. Samples were divided into four groups (n=7) ((1) experimental toothpaste containing hemp (H) (SPC Kozmetik), (2) hemp oil (HO), (3) Sensodyne Repair and Protection toothpaste (S) (GSK), ( 4) Control (no treatment)). The agents were applied using a pH-cycle model for seven days. All agents were kept on the surface of samples for 2 minutes and then applied for 1 minute using an electric toothbrush (Oral-B Test Drive (Genius)). Samples were evaluated with microhardness device, a fluorescence-assisted imaging device (FluoreCam), laser fluorescence device (DIAGNOdent Pen). Data were statistically analyzed with ANOVA and Kruskal Wallis H tests (p<0.05).Results: According to fluorescence and microhardness evaluations, the remineralization effect was similar in all treatment groups, except for hemp oil (p<0.01). Groups S (288.86±9.63), and H (284.86±10.41) showed significantly higher microhardness values compared to HO (238.57±10.89) (p<0.001). According to FluoreCam data, lesion size decreased in S (-1.83) and H (-1.07), while an increase was observed in HO (0.75). According to DIAGNOdent Pen data, the mineral increase in S (-8.42±1.18) and H (-8.29±1.03) was significantly higher than in HO (-3.57±2.06) (p<0.001).Conclusions: Herbal toothpaste containing hemp (H) demonstrated a similar remineralization effect to Fluor and NovaMin-containing toothpaste (S).

show abstract