Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Abstract

Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson’s Rats

“…Moreover, the observed enhanced neuron cell survival at low concentrations, coupled with lower toxicity compared to CBD alone, adds another layer of promise to the potential therapeutic application of CBD-LNP. These findings align with the broader understanding that nanoparticle formulations can enhance drug delivery efficiency and reduce toxicity [49,50]. The findings presented in this study not only demonstrate the successful preparation of CBD-LNP but also highlight its favorable physicochemical properties, stability, and reduced cytotoxicity, positioning it as a promising avenue for further exploration in the treatment of neurological disorders.…”

Protective Effects of Cannabidiol (CBD) against Qxidative Stress, but Not Excitotoxic-Related Neuronal Cell Damage—An In Vitro Study

“…The concentration-dependent opposite effects of CBD on neuronal survival suggest that its blood and brain concentration needs to be controlled. In connection with this, the CBD-loaded nanocarriers are currently being designed to overcome its poor oral bioavailability and improve the therapeutic efficacy of this compound [24,51,52]. Although clinical trials showed that CBD has an excellent safety profile and could be beneficial in the treatment of various neurological and neuropsychiatric conditions such as epilepsy, chronic pain, inflammation, anxiety, and neurodegenerative diseases, some undesired effects of this drug on hepatic drug metabolism and transport, fertility and in vitro cell viability were reported [53][54][55].…”

Cannabidiol-Loaded Solid Lipid Nanoparticles Ameliorate the Inhibition of Proinflammatory Cytokines and Free Radicals in an In Vitro Inflammation-Induced Cell Model

“…Understanding the inherent challenges associated with the bioavailability and degradation of CBD, our study has placed a significant emphasis on these aspects during the formulation of our SLNs. CBD, a compound with notable therapeutic potential, faces limitations in clinical applications due to its low bioavailability and susceptibility to degradation [31,32]. We have optimized the encapsulation efficiency (EE) and drug loading (DL) parameters of our SLNs through meticulous formulation strategies to address these challenges.…”