Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma

Vuolo, Francieli; Abreu, Soraia C.; Michels, Monique; Xisto, Débora G.; Blánco, N.; Hallak, Jaime E. C.; Zuardi, Antônio Waldo; Crippa, José Alexandre S; Reis, Cardine Martins dos; Bahl, Marina Mônica; Pizzichinni, Emílio; Silva, Rosemeri Maurici da; Pizzichinni, Márcia; Rocco, Patrícia Rieken Macêdo; Dal‐Pizzol, Felipe

doi:10.1016/j.ejphar.2018.11.029

Cited by 104 publications

(73 citation statements)

References 42 publications

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“…59 Use of ovalbumin to induce an asthma-like disease in mice demonstrated that some cytokines and chemokines induced in the lungs of mice that were suppressed by CBD (IL-4, IL-5, IL-13, and eotaxin) were differentially regulated by CB receptors. 60 Specifically, CBD-induced suppression of IL-5 was reversed in the presence of the CB 2 receptor antagonist in bronchoalveolar lavage fluid and lung tissue, but there was no clear receptor dependence identified for CBD's suppression of IL-4, IL-13, or eotaxin. 60 Thus, several studies do suggest a possible role for cannabinoid receptors in CBD-mediated suppression of inflammatory effects.…”

Section: Identification Of Cbd Receptors and Other Targetsmentioning

confidence: 93%

Immune Responses Regulated by Cannabidiol

Nichols

Kaplan

2020

Cannabis and Cannabinoid Research

209

176

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Introduction: Cannabidiol (CBD) as Epidiolex Ò (GW Pharmaceuticals) was recently approved by the U.S. Food and Drug Administration (FDA) to treat rare forms of epilepsy in patients 2 years of age and older. Together with the increased societal acceptance of recreational cannabis and CBD oil for putative medical use in many states, the exposure to CBD is increasing, even though all of its biological effects are not understood. Once such example is the ability of CBD to be anti-inflammatory and immune suppressive, so the purpose of this review is to summarize effects and mechanisms of CBD in the immune system. It includes a consideration of reports identifying receptors through which CBD acts, since the ' 'CBD receptor,' ' if a single one exists, has not been definitively identified for the myriad immune system effects. The review then provides a summary of in vivo and in vitro effects in the immune system, in autoimmune models, with a focus on experimental autoimmune encephalomyelitis, and ends with identification of knowledge gaps. Conclusion: Overall, the data overwhelmingly support the notion that CBD is immune suppressive and that the mechanisms involve direct suppression of activation of various immune cell types, induction of apoptosis, and promotion of regulatory cells, which, in turn, control other immune cell targets.

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Section: Identification Of Cbd Receptors and Other Targetsmentioning

confidence: 93%

Immune Responses Regulated by Cannabidiol

Nichols

Kaplan

2020

Cannabis and Cannabinoid Research

209

176

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“…Asthma, as a common chronic airway disease, affects approximately 300 million people in the world [1]. Up to now, asthma is still a major problem to public health, and the prevalence of asthma is increasing in developing countries and undeveloped countries because of late diagnosis and poor treatment [2].…”

Section: Introductionmentioning

confidence: 99%

MiR-203a-3p regulates TGF-β1-induced epithelial–mesenchymal transition (EMT) in asthma by regulating Smad3 pathway through SIX1

Fan

2020

Bioscience Reports

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Asthma is a common chronic airway disease with increasing prevalence. MicroRNAs act as vital regulators in cell progressions and have been identified to play crucial roles in asthma. The objective of the present study is to clarify the molecular mechanism of miR-203a-3p in the development of asthma. The expression of miR-203a-3p and Sine oculis homeobox homolog 1 (SIX1) were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The protein levels of SIX1, fibronectin, E-cadherin, vimentin, phosphorylated-drosophila mothers against decapentaplegic 3 (p-Smad3) and Smad3 were measured by Western blot. The interaction between miR-203a-3p and SIX1 was confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. MiR-203a-3p was down-regulated and SIX1 was up-regulated in asthma serums, respectively. Transforming growth factor-β1 (TGF-β1) treatment induced the reduction of miR-203a-3p and the enhancement of SIX1 in BEAS-2B and 16HBE cells in a time-dependent manner. Subsequently, functional experiments showed the promotion of epithelial–mesenchymal transition (EMT) induced by TGF-β1 treatment could be reversed by miR-203a-3p re-expression or SIX1 deletion in BEAS-2B and 16HBE cells. SIX1 was identified as a target of miR-203a-3p and negatively regulated by miR-203a-3p. Then rescue assay indicated that overexpressed miR-203a-3p ameliorated TGF-β1 induced EMT by regulating SIX1 in BEAS-2B and 16HBE cells. Moreover, miR-203a-3p/SIX1 axis regulated TGF-β1 mediated EMT process in bronchial epithelial cells through phosphorylating Smad3. These results demonstrated that MiR-203a-3p modulated TGF-β1-induced EMT in asthma by regulating Smad3 pathway through targeting SIX1.

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“…It is currently advertised to benefit many different maladies including sinusitis and allergy. Although there have been a couple of studies evaluating its role in airway inflammation, there are currently no studies on its efficacy in sinusitis or rhinitis . Consumption of CBD oil is also not without risks, as it can cause dry mouth, drowsiness, fatigue, diarrhea, and interact with anticoagulant medications.…”

Section: Discussionmentioning

confidence: 99%

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

Gettelfinger

Ting

et al. 2020

Int Forum Allergy Rhinol

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Background Sinusitis and rhinitis are common diseases for which patients seek medical attention. Alternative therapies constitute a multibillion‐dollar industry despite poorly established efficacy and safety profiles. This study was designed to identify and grade the evidence for alternative therapies purported to treat sinusitis and rhinitis. Methods A modified Delphi method was used to establish a consensus opinion among rhinology experts of the current evidence for efficacy, potential harm, and future research needs for alternative therapies in sinusitis and rhinitis. Following the initial Delphi round of discussion, a Google search query was performed to identify topics and review online reports of benefit. Subsequent rounds established search criteria and inclusion/exclusion criteria for a systematic literature review utilizing PubMed, EMBASE, and Cochrane databases. Centre for Evidence‐Based Medicine (CEBM) and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) criteria were used to assess levels of evidence and recommendations. Final Delphi rounds were performed until consensus opinions could be reached. Results Over 60 potential alternative therapies for sinusitis and rhinitis were identified. The literature review included 2066 titles with 220 full‐text articles found to be relevant. Most of the therapies had little to no scientific evidence; however, acupuncture, capsaicin, bromelain, and butterbur extract currently have low to moderate‐high GRADE rating. Allergic rhinitis was the most common disease studied. Conclusion Some alternative therapies show promise as potential treatments for sinusitis and rhinitis, mostly compared to placebo. Comparisons to traditional therapies are lacking. For other alternative therapies, many websites included unsubstantiated claims of benefit and ignored potential side effects for which patients should be warned appropriately.

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Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma

Cited by 104 publications

References 42 publications

Immune Responses Regulated by Cannabidiol

Immune Responses Regulated by Cannabidiol

MiR-203a-3p regulates TGF-β1-induced epithelial–mesenchymal transition (EMT) in asthma by regulating Smad3 pathway through SIX1

Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method

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