Cannabidiol to Improve Mobility in People with Multiple Sclerosis

Rudroff, Thorsten; Sosnoff, Jacob J.

doi:10.3389/fneur.2018.00183

Cited by 22 publications

(14 citation statements)

References 25 publications

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“…Cannabis pharmacological action is dose-dependent and can induce many adverse effects (AEs), principally related to THC, due to unintentional overdosing [ 7 ]. The typical symptoms of cannabis acute intoxication that have been reported are dizziness, confusion, tachycardia, postural hypotension, dysphoria, panic depression, hallucinations, allergic reactions, vomiting, and diarrhea [ 7 , 137 , 138 ]. Furthermore, withdrawal symptoms, such as irritability, aggression, anxiety, insomnia, decreased appetite, tremors, sweating, and headaches may appear after the abrupt cessation of the long-term administration of high doses of cannabis [ 7 ].…”

Section: Phytochemistry Of C Sativamentioning

confidence: 99%

The Medicinal Natural Products of Cannabis sativa Linn.: A Review

et al. 2022

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Cannabis sativa is known among many cultures for its medicinal potential. Its complexity contributes to the historical application of various parts of the plant in ethno-medicines and pharmacotherapy. C. sativa has been used for the treatment of rheumatism, epilepsy, asthma, skin burns, pain, the management of sexually transmitted diseases, difficulties during child labor, postpartum hemorrhage, and gastrointestinal activity. However, the use of C. sativa is still limited, and it is illegal in most countries. Thus, this review aims to highlight the biological potential of the plant parts, as well as the techniques for the extraction, isolation, and characterization of C. sativa compounds. The plant produces a unique class of terpenophenolic compounds, called cannabinoids, as well as non-cannabinoid compounds. The exhaustive profiling of bioactive compounds and the chemical characterization and analysis of C. sativa compounds, which modern research has not yet fully achieved, is needed for the consistency, standardization, and the justified application of Cannabis sativa products for therapeutic purposes. Studies on the clinical relevance and applications of cannabinoids and non-cannabinoid phenols in the prevention and treatment of life-threatening diseases is indeed significant. Furthermore, psychoactive cannabinoids, when chemically standardized and administered under medical supervision, can be the legal answer to the use of C. sativa.

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Section: Phytochemistry Of C Sativamentioning

confidence: 99%

The Medicinal Natural Products of Cannabis sativa Linn.: A Review

et al. 2022

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“…Cannabis pharmacological action is dose dependent and can induce many adverse effects (AEs), principally related to THC, due to unintentional overdosing [83]. The typical symptoms of cannabis acute intoxication are dizziness, confusion, tachycardia, postural hypotension, dysphoria, panic, depression and hallucinations [19,[84][85][86]. Allergic reactions, vomiting and diarrhea are also reported [87].…”

Section: Medical Use and Physician's Recommendationsmentioning

confidence: 99%

Herbal Preparations of Medical Cannabis: A Vademecum for Prescribing Doctors

et al. 2020

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Cannabis has been used for centuries for therapeutic purposes. In the last century, the plant was demonized due to its high abuse liability and supposedly insufficient health benefits. However, recent decriminalization policies and new scientific evidence have increased the interest in cannabis therapeutic potential of cannabis and paved the way for the release of marketing authorizations for cannabis-based products. Although several synthetic and standardized products are currently available on the market, patients’ preferences lean towards herbal preparations, because they are easy to handle and self-administer. A literature search was conducted on multidisciplinary research databases and international agencies or institutional websites. Despite the growing popularity of medical cannabis, little data is available on the chemical composition and preparation methods of medical cannabis extracts. The authors hereby report the most common cannabis preparations, presenting their medical indications, routes of administration and recommended dosages. A practical and helpful guide for prescribing doctors is provided, including suggested posology, titration strategies and cannabinoid amounts in herbal preparations obtained from different sources of medical cannabis.

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“…In addition for its anti-tumor properties [51], CBD has been reported to induce the following effects: analgesic [52], neuroprotective [53], antiemetic [54], anticonvulsivant [55], anti-inflammatory [55], and antispasmodic [56]. Thus, studies have shown its therapeutic potential not only in different types of malignant disorders [51], but also in the treatment of: epilepsy [57]; nausea and vomiting or other side effects caused by cytostatic therapy [54]; spasticity as well as other symptoms like tremor, bladder dysfunction, disease progression, inflammation, cognition in multiple sclerosis [58]; neuropatic and chronic pain [59]; spinal cord injury [60]; Parkinson’s and Alzheimer’s disease [61]; post-traumatic stress disorder and anxiety [62]; schizophrenia [63]; pulmonary disease [64]. Other therapeutic uses of CBD might be in the treatment of cannabis and tobacco addiction, although much more research is needed [65].…”

Section: Pharmacology Toxicology and Route Of Administrationmentioning

confidence: 99%

Cannabidiol—from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer

Kis

Ifrim

Buda

et al. 2019

IJMS

108

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Cannabis sativa L. is a plant long used for its textile fibers, seed oil, and oleoresin with medicinal and psychoactive properties. It is the main source of phytocannabinoids, with over 100 compounds detected so far. In recent years, a lot of attention has been given to the main phytochemicals present in Cannabis sativa L., namely, cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC). Compared to THC, CBD has non-psychoactive effects, an advantage for clinical applications of anti-tumor benefits. The review is designed to provide an update regarding the multi-target effects of CBD in different types of cancer. The main focus is on the latest in vitro and in vivo studies that present data regarding the anti-proliferative, pro-apoptotic, cytotoxic, anti-invasive, anti-antiangiogenic, anti-inflammatory, and immunomodulatory properties of CBD together with their mechanisms of action. The latest clinical evidence of the anticancer effects of CBD is also outlined. Moreover, the main aspects of the pharmacological and toxicological profiles are given.

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Cannabidiol to Improve Mobility in People with Multiple Sclerosis

Cited by 22 publications

References 25 publications

The Medicinal Natural Products of Cannabis sativa Linn.: A Review

The Medicinal Natural Products of Cannabis sativa Linn.: A Review

Herbal Preparations of Medical Cannabis: A Vademecum for Prescribing Doctors

Cannabidiol—from Plant to Human Body: A Promising Bioactive Molecule with Multi-Target Effects in Cancer

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