Cannabinoid-free<i>Cannabis sativa</i>L. grown in the Po valley: evaluation of fatty acid profile, antioxidant capacity and metabolic content

Lesma, Giordano; Consonni, Roberto; Gambaro, Veniero; Remuzzi, C.; Roda, Gabriella; Silvani, Alessandra; Vece, Vito; Visconti, Giacomo Luca

doi:10.1080/14786419.2014.926354

Cited by 41 publications

(24 citation statements)

References 15 publications

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“…The main phenolic compounds that have been detected in Cannabis sativa fruits, seeds, and roots are lignans, belonging to two main groups known as phenolic amides and lignanamides [40,41]. Lignans show a wide range of health-promoting properties including antioxidant, antiviral, antidiabetic, antitumorigenic, and anti-obesity activities [42].…”

Section: Resultsmentioning

confidence: 99%

Effect οf Genotype and Growing Year on the Nutritional, Phytochemical, and Antioxidant Properties of Industrial Hemp (Cannabis sativa L.) Seeds

et al. 2019

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Cannabis sativa L. seeds have been an important source of protein, oil, and dietary fiber for human and animals. Currently, there is a growing interest in the commercial products of these seeds, which are recognized as a legitimate source of medicaments, cosmeceuticals, and nutraceuticals. The objective of this study was to investigate the nutritional, phytochemical composition, and antioxidant properties of seeds from seven hemp cultivars grown in Greece for three consecutive years. All the measured parameters strongly varied under the influence of growing year and genotype. In particular, protein, oil, and carbohydrates’ content of hemp seeds as well as fatty acids’ composition were mainly affected by genotype, whereas the growing year had a major effect on phytochemical components and antioxidant activity, which was determined by the 2,2′-azino-bis (3-ethylbenzthiazoline sulfonate) (ABTS) and ferric-reducing antioxidant power (FRAP) assays. Moreover, a predominant effect of the year was observed for phenolic profiles as determined by high-performance liquid chromatography and total carotenoids’ content. This study suggests that hemp seeds could be a promising food crop as a result of their high nutritive traits and antioxidant potential. A comparison of the studied cultivars, showed that Finola seeds had the highest oil and protein contents and, thus, appeared to be the most promising cultivar for cultivation in Greece.

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Section: Resultsmentioning

confidence: 99%

Effect οf Genotype and Growing Year on the Nutritional, Phytochemical, and Antioxidant Properties of Industrial Hemp (Cannabis sativa L.) Seeds

et al. 2019

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“…Pollastro et al [18] reported that hemp synthesizes characteristic molecules, such as prenylated flavonoids, stilbenoid derivatives, and lignamides, which require further investigations. Other studies [19,20] reported high amounts of polyphenols in hempseed cultivars Finola, Futura, Felina, and Carmagnola (Italy) with antioxidant activity. A special role is attributed to flavonoids, acting as free-radical scavengers and chelators of metal ions.…”

Section: Introductionmentioning

confidence: 90%

Antioxidant Effects of Hemp (Cannabis sativa L.) Inflorescence Extract in Stripped Linseed Oil

et al. 2020

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The ability of hemp (Cannabis sativa L.) inflorescence extract to counteract lipid oxidation was studied in stripped linseed oil. The ethanolic extract was characterized in terms of terpenes (6.00 mg/mL), cannabidiol (4.99% w/w), phenolic compounds (1.80 mg gallic acid equivalents (GAE)/mL), antiradical, and metal ion-chelating activities (50% effective concentration (EC50) of 2.47 mg/mL and 0.39 mg/mL, respectively). The stripped linseed oil, used as control (CO), was mixed with hemp extract (HO) or α-tocopherol (EO) at a ratio of 0.6% (w/w) and stored for 7 days in darkness at 40 °C. Hemp extract reduced the oxidation and lipolysis processes. At the end of the storage, HO showed a significantly higher level of α-linolenic acid (ALA; 26.64 g/100 g), lower peroxide value (PV) (21.19 meq O2/kg oil), and lower hexanal content (7.67 mmol/kg oil) than those found in the control. In contrast, EO showed a marked lipolysis (the free fatty acids increased by 42.57%) and a noticeable oxidation, since the ALA content decreased by 2.10% and a PV of 50 meq O2/kg oil was observed. This study demonstrates that hemp inflorescences can be used as a source of natural antioxidants in vegetable oils and lipid products to retard their oxidation, especially those characterized by a high degree of unsaturation.

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“…These include the O -glycoside versions of the aglycones apigenin, luteolin, kaempferol and quercetin, as well as cannflavin A and cannflavin B, which are methylated isoprenoid flavones that are unique to Cannabis ( Figure 2 ) ( Ross et al, 2005 ). Phenolic amides and lignanamides have also been described in Cannabis fruits and roots ( Sakakibara et al, 1992 ; Lesma et al, 2014 ). The lignanamides belong to the lignan class of compounds and include cannabisin-like compounds (of the types A-, B-, C-, D-, E-, F-, and G) and grossamide ( Flores-Sanchez and Verpoorte, 2008 ).…”

Section: Hemp Phytochemicals: Their Production Pathways and Myriad Ofmentioning

confidence: 99%

Cannabis sativa: The Plant of the Thousand and One Molecules

2016

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Cannabis sativa L. is an important herbaceous species originating from Central Asia, which has been used in folk medicine and as a source of textile fiber since the dawn of times. This fast-growing plant has recently seen a resurgence of interest because of its multi-purpose applications: it is indeed a treasure trove of phytochemicals and a rich source of both cellulosic and woody fibers. Equally highly interested in this plant are the pharmaceutical and construction sectors, since its metabolites show potent bioactivities on human health and its outer and inner stem tissues can be used to make bioplastics and concrete-like material, respectively. In this review, the rich spectrum of hemp phytochemicals is discussed by putting a special emphasis on molecules of industrial interest, including cannabinoids, terpenes and phenolic compounds, and their biosynthetic routes. Cannabinoids represent the most studied group of compounds, mainly due to their wide range of pharmaceutical effects in humans, including psychotropic activities. The therapeutic and commercial interests of some terpenes and phenolic compounds, and in particular stilbenoids and lignans, are also highlighted in view of the most recent literature data. Biotechnological avenues to enhance the production and bioactivity of hemp secondary metabolites are proposed by discussing the power of plant genetic engineering and tissue culture. In particular two systems are reviewed, i.e., cell suspension and hairy root cultures. Additionally, an entire section is devoted to hemp trichomes, in the light of their importance as phytochemical factories. Ultimately, prospects on the benefits linked to the use of the -omics technologies, such as metabolomics and transcriptomics to speed up the identification and the large-scale production of lead agents from bioengineered Cannabis cell culture, are presented.

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Cannabinoid-freeCannabis sativaL. grown in the Po valley: evaluation of fatty acid profile, antioxidant capacity and metabolic content

Cited by 41 publications

References 15 publications

Effect οf Genotype and Growing Year on the Nutritional, Phytochemical, and Antioxidant Properties of Industrial Hemp (Cannabis sativa L.) Seeds

Effect οf Genotype and Growing Year on the Nutritional, Phytochemical, and Antioxidant Properties of Industrial Hemp (Cannabis sativa L.) Seeds

Antioxidant Effects of Hemp (Cannabis sativa L.) Inflorescence Extract in Stripped Linseed Oil

Cannabis sativa: The Plant of the Thousand and One Molecules

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