Cannabinoïdes et thérapeutique

Fabresse, Nicolas; Becam, Jenny; Carrara, Laura; Descoeur, Juliette; Mario, Mélanie Di; Drevin, Guillaume; Duval, Thibault; Hannas, Nassim; Lanot, Thomas; Marillier, Mathieu; Senechal, Honorine; Salle, Sophie

doi:10.1016/j.toxac.2019.06.002

Cited by 2 publications

(3 citation statements)

References 132 publications

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“…Il semblerait par ailleurs que le CBD agisse comme un agoniste inverse sur les récepteurs CB1 cérébraux, diminuant de ce fait l'activité psychotrope du THC lorsqu'il lui est associé, notamment dans les joints de marijuana [16,17].…”

Section: Consommation Du Cbdunclassified

“…En France, d'un point de vue règlementaire, le CBD n'est pas classé comme stupéfiant. Ces produits ne sont donc autorisés que s'ils ne contiennent pas de THC et s'ils ont été obtenus à partir de variétés et de parties de plantes autorisées [17,18]. Il peut donc être utile parfois de distinguer la présence de THC et de CBD dans des échantillons biologiques.…”

Section: Consommation Du Cbdunclassified

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Cannabis : quels examens biologiques en milieu hospitalier ?

Alvarez

2020

La Presse Médicale Formation

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Section: Consommation Du Cbdunclassified

Cannabis : quels examens biologiques en milieu hospitalier ?

Alvarez

2020

La Presse Médicale Formation

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“…Since tobacco is not needed, the risks of dependence and addiction caused by nicotine inhalation are reduced. Compared to the oral route that is slow to cause an effect, unpredictable and with interindividual variability in pharmacokinetics [21], vaporisation provides delivery characteristics (yield and kinetic) that are considered very similar to those of smoking. The only requirement is that the temperature of the heating chamber prefilled with grinded cannabis flower tops be high enough (>100°C) to rapidly convert all the acidic precursors (THC acid A [THCA] and cannabidiolic acid [CBDA]) of the cannabinoids into their corresponding active and neutral forms (THC and CBD) [22, 23] and to subsequently vaporise them.…”

Section: Introductionmentioning

confidence: 99%

Development of a Vaping Machine for the Sampling of THC and CBD Aerosols Generated by Two Portable Dry Herb Cannabis Vaporisers

Carrara¹,

Giroud²,

Concha-Lozano³

2020

Med Cannabis Cannabinoids

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Cannabis sativa is known for its recreational use, but also for its therapeutic potential. There has been wide discussion over the use of cannabis for medical purposes in recent years, especially because a consensus has not been reached regarding its risk/benefit balance. Among the more common modes of administration, vaping with a vaporiser is most frequently used for self-medication. Vaping seems to be a better alternative to preventing adverse health effects due to toxic compounds produced during combustion when cannabis is smoked. However, the delivery kinetics and efficiency of most portable vaporisers are not fully characterised with an appropriate vaping regime. This determination requires a specific vaping machine operating under realistic puffing conditions. In this study, a vaping machine was conceived to fit with the common uses of portable vaporisers that requires conditions different from those used for electronic cigarettes. The experimental setup in this study was optimised to sample aerosolised cannabinoids. The delivery kinetics, efficiency, and decarboxylation yields of two commercially available vaporisers (DaVinci ® and Mighty Medic ®) were evaluated for delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Among all tested sampling supports, the glass fibre filter is the most efficient medium to collect mixed THC and CBD aerosols. From the delivery kinetics of cannabinoids, a single-parameter model was used to calculate the extraction coefficient of each vaporiser. The results show that the Mighty Medic ® vaporiser had a higher extraction coefficient (0.39) and a more immediate release of cannabinoids than the DaVinci ® vaporiser (0.16), which had a gradual and slower rate of vaporisation. This parameter could be a quantitative input in pharmacokinetic models of administration of volatile compounds using vaporisers and a useful tool for the comparison of vaporisers.

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Cannabinoïdes et thérapeutique

Cited by 2 publications

References 132 publications

Cannabis : quels examens biologiques en milieu hospitalier ?

Cannabis : quels examens biologiques en milieu hospitalier ?

Development of a Vaping Machine for the Sampling of THC and CBD Aerosols Generated by Two Portable Dry Herb Cannabis Vaporisers

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