Cannabinoids for nausea and vomiting related to chemotherapy: Overview of systematic reviews

Schussel, Victor Cavalcante; Kenzo, Lucas; Santos, Andréia Costa; Bueno, Júlia; Yoshimura, Ellen; Latorraca, Carolina de Oliveira Cruz; Pachito, Daniela Vianna; Riera, Rachel

doi:10.1002/ptr.5975

Cited by 37 publications

(27 citation statements)

References 18 publications

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“…Nabilone is available, in a polyvinylpyrrolidone carrier, as a capsule (1 mg of drug). It displays antiemetic properties and is used for the control of the nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetics [ 59 ].…”

Section: Current Drug Dosage Forms and Novel Delivery Systemsmentioning

confidence: 99%

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Bruni¹,

et al. 2018

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There is a growing body of evidence to suggest that cannabinoids are beneficial for a range of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms of multiple sclerosis, anorexia, schizophrenia and other conditions. The transformation of cannabinoids from herbal preparations into highly regulated prescription drugs is therefore progressing rapidly. The development of such drugs requires well-controlled clinical trials to be carried out in order to objectively establish therapeutic efficacy, dose ranges and safety. The low oral bioavailability of cannabinoids has led to feasible methods of administration, such as the transdermal route, intranasal administration and transmucosal adsorption, being proposed. The highly lipophilic nature of cannabinoids means that they are seen as suitable candidates for advanced nanosized drug delivery systems, which can be applied via a range of routes. Nanotechnology-based drug delivery strategies have flourished in several therapeutic fields in recent years and numerous drugs have reached the market. This review explores the most recent developments, from preclinical to advanced clinical trials, in the cannabinoid delivery field, and focuses particularly on pain and inflammation treatment. Likely future directions are also considered and reported.

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Section: Current Drug Dosage Forms and Novel Delivery Systemsmentioning

confidence: 99%

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Bruni¹,

et al. 2018

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“…However, they appear to have a greater effect on the suppression of nausea and vomiting compared to placebo and they have the same effect compared to prochlorperazine. The combination of cannabinoids and other antiemetic drugs does not add additive effects and is associated with a greater number of undesirable effects (cognitive impairment, drowsiness) (43). Based on these data, the use of cannabinoids in the treatment of chemotherapy-induced nausea and vomiting cannot be unambiguously encouraged or rejected.…”

Section: Cannabinoids In the Treatment Of Pain And As A Symptomatic Tmentioning

confidence: 99%

The role of cannabinoids in the treatment of cancer

Večeřa¹,

Gabrhelik²,

Prášil³

et al. 2020

BLL

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The aim of this review article is to summarize current knowledge about the role of cannabinoids and cannabinoid receptors in tumor disease modulation and to evaluate comprehensively the use of cannabinoids in cancer patients. METHOD: According to the PRISMA protocol, we have included data from a total of 105 articles. RESULTS: Cannabinoids affect cancer progression by three mechanisms. The most important mechanism is the stimulation of autophagy and affecting the signaling pathways leading to apoptosis. The most important mechanism of this process is the accumulation of ceramide. Cannabinoids also stimulate apoptosis by mechanisms independent of autophagy. Other mechanisms by which cannabinoids affect tumor growth are inhibition of tumor angiogenesis, invasiveness, metastasis, and the modulation of the anti-tumor immune response. CONCLUSION: In addition to the symptomatic therapy of cancer patients, the antitumor effects of cannabinoids (whether in monotherapy or in combination with other cancer therapies) have promising potential in the treatment of cancer patients. More clinical trials are needed to demonstrate the antitumor effect of cannabinoids (Tab. 1, Fig. 1, Ref. 167).

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“…In a similar newer review of systematic reviews, cannabinoids seemed to be more effective than placebo, equal to prochlorperazine for reducing CINV, and to be preferred by patients. According to the authors, although there is no good quality evidence to recommend or not the use of them for CINV, they represent a valuable option for treating CINV, despite the adverse events related to treatment [72].…”

Section: The Medical Indications For Cannabinoidsmentioning

confidence: 99%

Prospects for the Use of Cannabinoids in Oncology and Palliative Care Practice: A Review of the Evidence

Dzierżanowski

2019

Cancers

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There is an increased interest in the use of cannabinoids in the treatment of symptoms in cancer and palliative care patients. Their multimodal action, in spite of limited efficacy, may make them an attractive alternative, particularly in patients with multiple concomitant symptoms of mild and moderate intensity. There is evidence to indicate cannabis in the treatment of pain, spasticity, seizures, sleep disorders, nausea and vomiting, and Tourette syndrome. Although the effectiveness of cannabinoids is limited, it was confirmed in neuropathic pain management and combination with opioids. A relatively favorable adverse effects profile, including no depressive effect on the respiratory system, may make cannabis complement a rather narrow armamentarium that is in the disposition of a palliative care professional.

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Cannabinoids for nausea and vomiting related to chemotherapy: Overview of systematic reviews

Cited by 37 publications

References 18 publications

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

The role of cannabinoids in the treatment of cancer

Prospects for the Use of Cannabinoids in Oncology and Palliative Care Practice: A Review of the Evidence

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