Cannabinoids Identification in Lung Tissues of Young Cannabis Smokers Operated for Primary Spontaneous Pneumothorax and Correlation with Pathologic Findings

Bisconti, Mario; Marulli, Giuseppe; Pacifici, Roberta; Sollitto, Francesco; Nex, Giulia; Trabucco, Xenia; Ardò, Nicoletta Pia; Rotolo, Maria Concetta; Iaco, Giulia De; Panza, Teodora; Brascia, Debora; Schiavone, Marcella; Signore, Francesca Del; Pistelli, Francesco; Palma, Angela De

doi:10.1159/000503456

Cited by 14 publications

(12 citation statements)

References 22 publications

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“…Increasing evidence supports the association of marijuana smoking with bullous emphysema and spontaneous pneumothorax. A prospective study supports the correlation between marijuana abuse and primary spontaneous pneumothorax [10]. A case-controlled study by Stefani et al revealed that cannabis smokers are at significant risk of developing bullous lung disease and have a higher incidence of tension pneumothorax compared to both tobacco smokers and nonsmokers [9].…”

Section: Discussionmentioning

confidence: 76%

Recurrent Spontaneous Pneumothorax Associated With Marijuana Abuse: Case Report and Literature Review

Manasrah

Sbihi

Qasem³

et al. 2021

Cureus

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Marijuana is the most commonly used illicit recreational drug in the United States. Growing public support for marijuana law reform has resulted in a significant increase in its use. The harmful pulmonary consequences of chronic marijuana smoking are less researched and discussed than those of tobacco smoking. We present a case of recurrent spontaneous pneumothorax in a patient with heavy, persistent marijuana abuse who has no past medical or surgical histories and denied smoking cigarettes or other illicit substance use.

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Section: Discussionmentioning

confidence: 76%

Recurrent Spontaneous Pneumothorax Associated With Marijuana Abuse: Case Report and Literature Review

Manasrah

Sbihi

Qasem³

et al. 2021

Cureus

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“…These features suggest a co-carcinogen role for cannabis smoke, which contains a greater quantity than tobacco of polycyclic aromatic hydrocarbons and tar particles [4]. Moreover, the presence of cannabinoids and pathologic alterations have been demonstrated in the lung apex of young cannabis smokers with pneumothorax [15]. In our clinical experience, tumours in the CTS group are frequently diagnosed at an advanced stage.…”

mentioning

confidence: 80%

Cannabis use and lung cancer: time to stop overlooking the problem?

Betser

Glorion

Mordant³

et al. 2021

Eur Respir J

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After tobacco, cannabis is the most widely used drug worldwide, and the move to legalise it is growing in more and more countries. The literature about the involvement of cannabis smoking on the development of lung cancer is scarce and most often reassuring [1][2][3], even though the concentration of carcinogens in cannabis smoke is unquestionably greater than that in tobacco smoke [4]. Moreover, recent studies on cannabis tend to focus on possible therapeutic effects [5]. Studies of the carcinogenic impact of cannabis are indeed limited by its frequent association with tobacco smoking and by its illegal status in most countries [6].Our study aimed to describe the prevalence and study the clinical impact of cannabis use among young patients who underwent surgical resection for primary lung cancer.All patients aged 50 years or less who underwent resection for primary lung cancer in three French University hospitals between 2018 and 2020 were prospectively included in an administrative database and retrospectively reviewed. Patients were stratified into three groups: cannabis and tobacco smokers (CTS), tobacco smokers only (TS) and never smokers (NS).Each patient was contacted by phone: information on demographics, smoking history, recreational drug use, passive smoking exposure, alcohol consumption and family history of malignancy was collected. In case of cannabis and/or tobacco use, patients were asked about starting age, quantity, frequency and duration of use, and the characteristics of smoking. We also retrospectively analysed all medical files to find whether cannabis use was reported. Tumour characteristics (localisation, histology, molecular profile and staging according to the eighth edition of the TNM Classification of Malignant Tumors), surgical plan, post-operative outcomes, presence of emphysema on thoracic computed tomography scan, and oncological follow-up were also collected.All patients gave informed consent to allow medical data prospective collection and retrospective analysis. Data collection was declared to the French National Committee for Informatics and Freedom (CNIL, 2219959). Study protocol was approved by the ethics committee of the French Society of Thoracic and Cardio-vascular Surgery (CERC-SFCTCV, 2020-09-08-02-PRAD).Group comparison for categorical and continuous variables was performed with Fisher's exact (or Chi-square) and Mann-Whitney U-(or Kruskal-Wallis) tests, respectively. Statistical analyses were performed using GraphPad Prism 8.0 (San Diego, CA, USA). p-value <0.05 was considered statistically significant.Between 2018 and 2020, 1329 patients underwent lung resection for primary lung cancer, in all cases nonsmall-cell cancer (NSCLC). Among them, 77 patients were aged 50 years or less and accounted for the study group. 71 patients (92%) answered our phone interview. The data of the remaining six patients were collected through contact with their general practitioner and referent oncologist. 43% (n=33) of patients were cannabis and tobacco users (CTS group), 34% (n=26) were ...

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“…This condition usually occurs in young people, although there are more elderly patients with pneumothorax. With the maturity of rapid rehabilitation and the accumulation of minimally invasive surgical techniques in recent years, lung surgery has entered the era of minimally invasive surgery represented by thoracoscopy [8] . At present, the approaches of thoracoscopic bullectomy include the classic 3-4-hole VATS, two-hole VATS, and single-hole VATS [9,10] .…”

Section: Discussionmentioning

confidence: 99%

An Exploration of the Treatment of Spontaneous Progressive Hemopneumothorax in Young People

Zhang

Guo

Zhang

et al. 2022

PAR

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Objective: To explore an effective treatment for spontaneous progressive hemopneumothorax in young people. Methods: Thirty-four young patients with spontaneous progressive hemopneumothorax from January 2018 to December 2019 were selected to be included in the control group for retrospective analysis; from January 2020 to December 2021, 69 young patients with spontaneous progressive hemopneumothorax were selected to be included in the study group. The control group was treated with double-port thoracoscopic bullectomy, whereas the study group was treated with single-port thoracoscopic bullectomy. The intraoperative blood loss, operation time, tube retention time, VAS score, postoperative air leakage, and 1-year recurrence of the patients in the two groups were observed and analyzed. Results: The perioperative conditions of the patients in the study group, including intraoperative bleeding loss, operation time, tube retention time, and VAS scores, were 15.12 ± 1.36, 54.69 ± 18.78, 2.14 ± 0.98, and 3.25 ± 0.14, respectively. The perioperative conditions of the patients in the control group, including intraoperative bleeding loss, operation time, tube retention time, and VAS scores, were 22.69 ± 2.01, 55.36 ± 19.01, 4.21 ± 1.01, and 5.36 ± 0.45, respectively; other than the operation time, the differences in intraoperative blood loss, tube retention time, and VAS scores between the two groups were statistically significant (p < 0.05); after the surgery, two patients in the study group had postoperative air leakage, accounting for 2.90% and another two patients had recurrence one year after the surgery, accounting for 2.90%; on the other hand, three patients in the control group had postoperative air leakage, accounting for 8.82%, and two patients had recurrence one year after the surgery, accounting for 5.88%. However, ?2 test showed that p > 0.05. Conclusion: Treatment of spontaneous progressive hemopneumothorax in young people is better with single-port thoracoscopic bullectomy than with two-port thoracoscopic bullectomy, which effectively reduces intraoperative bleeding. The pain level is significantly better with single-port thoracoscopic bullectomy than with two-port thoracoscopic bullectomy, and the prognosis of patients is good with a low probability of recurrence for both, single- and two-port thoracoscopic bullectomy.

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Cannabinoids Identification in Lung Tissues of Young Cannabis Smokers Operated for Primary Spontaneous Pneumothorax and Correlation with Pathologic Findings

Cited by 14 publications

References 22 publications

Recurrent Spontaneous Pneumothorax Associated With Marijuana Abuse: Case Report and Literature Review

Recurrent Spontaneous Pneumothorax Associated With Marijuana Abuse: Case Report and Literature Review

Cannabis use and lung cancer: time to stop overlooking the problem?

An Exploration of the Treatment of Spontaneous Progressive Hemopneumothorax in Young People

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