Cannabinoids in Gynecological Diseases

Luschnig, Petra; Schicho, Rudolf

doi:10.1159/000499164

Cited by 16 publications

(25 citation statements)

References 111 publications

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“…Cannabis is potent in its gynecological actions, and cannabinoids might potentially influence the dysregulation of the endocannabinoid system whereby as specific agonists or antagonists (Luschnig and Schicho 2019 , Russo 2002 ). FMPs of Bangladesh have used Cannabis sativa for gynecological problems like excessive menstrual and its pain, erectile dysfunctions (Hasan et al 2015a , Rahmatullah et al 2010g , Siddique et al 2006 , Walid et al 2013 ).…”

Section: Discussionmentioning

confidence: 99%

A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh

Shakil

Gowan

Hughes³

et al. 2021

J Cannabis Res

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Background There is a worldwide interest in the use of Cannabis sativa for biomedicine purposes. Cannabis has ethnomedicinal usage as a natural medicine in Bangladesh and cultivated during the British Empire period for revenues. Objective Folk medicine practitioners (FMPs) from different districts of Bangladesh have been using Cannabis sativa, but until now there have not been any compiled studies particularly regarding this practice. Hence, this review is an effort to retrieve the traditional usage of Cannabis sativa as a phytomedicine from published ethnomedicinal studies. Methods and materials Information was searched by using the search terms “ethnomedicinal Cannabis sativa and Bangladesh”; “Bangladesh cannabaceae and ethnomedicinal survey”; “ganja, bhang and folk medicine Bangladesh”; “tetrahydrocannabinol (THC), cannabinoid and therapeutic, clinical trial”; and “cannabis and pharmacological/biological” and retrieved from ethnobotanical articles available on PubMed, Scopus, Science Direct, and Google Scholar databases. A search of the relevant scientific literature also was conducted to assess the efficacy of the ethnomedicinal usage of Cannabis sativa. Results While reviewing over 200 ethnomedicinal plants’ survey articles, we found that FMPs of Bangladesh from 12 different districts used Cannabis sativa to treat cited ailments like sleep-associated problems (n=5), neuropsychiatric and CNS problems (n=5), and infections and respiratory problems (n=5) followed by rheumatism, gastrointestinal, gynecological (n=4 each), cancer, sexual, and other ailments including hypertension, headache, itch, increases bile secretion, abortifacient, dandruff, fever, and urinary problems (n=1 each). There are a total of 15 formulations identified from the 11 out of 18 ethnomedicinal plant survey reports. The leaf was the main plant part used (53.8%), followed by root (23%), seed (7.7%) and flower, inflorescence, resin, and all parts 3.8% respectively. Conclusions Sales and cultivation of Cannabis are illegal at present in Bangladesh, but the use of Cannabis sativa as a natural phytomedicine has been practiced traditionally by folk medicine practitioners of Bangladesh for many years and validated through relevant pharmacological justification. Although Cannabis sativa possesses ethnomedicinal properties in the folk medicine of Bangladesh, it is, furthermore, needed to conduct biological research to consolidate pharmacological justification about the prospects and challenges of Cannabis and cannabinoids’ use in Bangladesh as safer biomedicine in the future.

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Section: Discussionmentioning

confidence: 99%

A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh

Shakil

Gowan

Hughes³

et al. 2021

J Cannabis Res

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“…In contrast, in a mouse analogue of early-stage EM, the activation resulted in an increased disease burden [ 75 ]. The complexity of the ECS superimposed on the two different mouse models used may account for the different results [ 76 ].…”

Section: Pain Receptors In Endometriosis-associated Nerve Fibresmentioning

confidence: 99%

Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?

Velho

Taube

Sehouli

et al. 2021

IJMS

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Endometriosis (EM) is an estrogen-dependent disease characterized by the presence of epithelial, stromal, and smooth muscle cells outside the uterine cavity. It is a chronic and debilitating condition affecting ~10% of women. EM is characterized by infertility and pain, such as dysmenorrhea, chronic pelvic pain, dyspareunia, dysuria, and dyschezia. Although EM was first described in 1860, its aetiology and pathogenesis remain uncertain. Recent evidence demonstrates that the peripheral nervous system plays an important role in the pathophysiology of this disease. Sensory nerves, which surround and innervate endometriotic lesions, not only drive the chronic and debilitating pain associated with EM but also contribute to a growth phenotype by secreting neurotrophic factors and interacting with surrounding immune cells. Here we review the role that peripheral nerves play in driving and maintaining endometriotic lesions. A better understanding of the role of this system, as well as its interactions with immune cells, will unearth novel disease-relevant pathways and targets, providing new therapeutics and better-tailored treatment options.

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“…99 The complexity of the ECS superimposed on the two different mouse models used may account for the different results. 38…”

Section: Endometriosis and Cannabinoidsmentioning

confidence: 99%

“…The ECS has also been linked to the menstrual dysregulation of polycystic ovarian syndrome (PCOS). 38 Endocanabinoids, 2-AG and AEA as well as CB1Rs and CB2Rs are upregulated in women with PCOS. 39,40 Moreover, CB2Rs is expressed at higher levels in the adipose tissue of women with PCOS versus controls, with possible implications for the metabolic implications of the ECS in women with PCOS.…”

Section: Introductionmentioning

confidence: 99%

Cannabinoids and chronic pelvic pain in women: Focus on endometriosis

Marcu

Gee

Lynn

2021

Journal of Endometriosis and Pelvic Pain Disorders

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Chronic pelvic pain in women is common and frequently difficult to treat. Chronic pelvic pain often develops in the setting of endometriosis, interstitial cystitis/bladder pain syndrome, and vulvodynia. Cannabinoids are a promising treatment modality for non-cancer chronic pain, but have not been studied in women with chronic pelvic pain nor in specific chronic pelvic pain conditions. This review focuses on the interaction of the endocannabinoid system with the menstrual cycles, with endometriotic lesions, and within the bladder. Furthermore, it provides a brief overview of existing literature of the effects of endocannabinoids on chronic pain generally, with a focus on neuropathic pain. Finally, it discusses limited data available regarding the use of cannabinoids in women with chronic pelvic pain conditions. In the opinion of the authors, cannabinoids are a reasonable treatment modality for refractory chronic pelvic pain, especially if a neuropathic component is suspected. Practitioners should expect a modest effect on pain levels with an acceptable safety profile.

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Cannabinoids in Gynecological Diseases

Cited by 16 publications

References 111 publications

A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh

A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh

Neurogenic Inflammation in the Context of Endometriosis—What Do We Know?

Cannabinoids and chronic pelvic pain in women: Focus on endometriosis

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