Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases

Abd-Nikfarjam, Bahareh; Dolati-Somarin, Amirhossein; Rahimi, Vafa Baradaran; Askari, Vahid Reza

doi:10.1002/biof.1936

Cited by 20 publications

(12 citation statements)

References 208 publications

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“…It is also used to help with sleep and to improve appetite. In recent years, there has been a growing interest in using Cannabis to treat epilepsy 9 – 11 and multiple sclerosis 12 – 16 . The two major classes of natural products found in Cannabis are cannabinoid and terpenoid compounds, both of which have been reported to possess anti-inflammatory and analgesic properties.…”

Section: Introductionmentioning

confidence: 99%

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CBGA ameliorates inflammation and fibrosis in nephropathy

Suzuki

Fleig

Penner

2023

Sci Rep

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Cannabidiol (CBD) is thought to have multiple biological effects, including the ability to attenuate inflammatory processes. Cannabigerols (CBGA and its decarboxylated CBG molecule) have pharmacological profiles similar to CBD. The endocannabinoid system has recently emerged to contribute to kidney disease, however, the therapeutic properties of cannabinoids in kidney disease remain largely unknown. In this study, we determined whether CBD and CBGA can attenuate kidney damage in an acute kidney disease model induced by the chemotherapeutic cisplatin. In addition, we evaluated the anti-fibrosis effects of these cannabinoids in a chronic kidney disease model induced by unilateral ureteral obstruction (UUO). We find that CBGA, but not CBD, protects the kidney from cisplatin-induced nephrotoxicity. CBGA also strongly suppressed mRNA of inflammatory cytokines in cisplatin-induced nephropathy, whereas CBD treatment was only partially effective. Furthermore, both CBGA and CBD treatment significantly reduced apoptosis through inhibition of caspase-3 activity. In UUO kidneys, both CBGA and CBD strongly reduced renal fibrosis. Finally, we find that CBGA, but not CBD, has a potent inhibitory effect on the channel-kinase TRPM7. We conclude that CBGA and CBD possess reno-protective properties, with CBGA having a higher efficacy, likely due to its dual anti-inflammatory and anti-fibrotic effects paired with TRPM7 inhibition.

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Section: Introductionmentioning

confidence: 99%

“…It is also used to help with sleep and to improve appetite. In recent years, there has been a growing interest in using Cannabis to treat epilepsy [9][10][11] and multiple sclerosis [12][13][14][15][16] . The two major…”

mentioning

confidence: 99%

CBGA ameliorates inflammation and fibrosis in nephropathy

Suzuki

Fleig

Penner

2023

Sci Rep

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“…29 Examples of neuroinflammatory diseases include multiple sclerosis, AD, and PD. 30 Gem can suppress the expression of pro-inflammatory molecules in human primary microglia via activation of PPARα. The studies suggest that Gem could have potential therapeutic value in several neuroinflammatory and NDs since it regulates both microglial activation and inflammatory gene expression in a PPARβ dependent manner, suggesting that Gem may represent a promising treatment for these conditions.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms

Ivraghi,

Zamanian,

Gupta

et al. 2023

CNS Neurosci Ther

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BackgroundGemfibrozil (Gem) is a drug that has been shown to activate PPAR‐α, a nuclear receptor that plays a key role in regulating lipid metabolism. Gem is used to lower the levels of triglycerides and reduce the risk of coronary heart disease in patients. Experimental studies in vitro and in vivo have shown that Gem can prevent or slow the progression of neurological disorders (NDs), including cerebral ischemia (CI), Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Neuroinflammation is known to play a significant role in these disorders.MethodThe literature review for this study was conducted by searching Scopus, Science Direct, PubMed, and Google Scholar databases.ResultThe results of this study show that Gem has neuroprotective effects through several cellular and molecular mechanisms such as: (1) Gem has the ability to upregulate pro‐survival factors (PGC‐1α and TFAM), promoting the survival and function of mitochondria in the brain, (2) Gem strongly inhibits the activation of NF‐κB, AP‐1, and C/EBPβ in cytokine‐stimulated astroglial cells, which are known to increase the expression of iNOS and the production of NO in response to proinflammatory cytokines, (3) Gem protects dopamine neurons in the MPTP mouse model of PD by increasing the expression of PPARα, which in turn stimulates the production of GDNF in astrocytes, (4) Gem reduces amyloid plaque pathology, reduces the activity of glial cells, and improves memory, (5) Gem increases myelin genes expression (MBP and CNPase) via PPAR‐β, and (6) Gem increases hippocampal BDNF to counteract depression.ConclusionAccording to the study, Gem was investigated for its potential therapeutic effect in NDs. Further research is needed to fully understand the therapeutic potential of Gem in NDs.

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“…In general, bioactive lipids in cell signaling include plant-derived compounds such as cannabinoids (terpeno-phenol compounds also known as phytocannabinoids) [ 1 , 2 ], terpenoids (including sterols) [ 3 , 4 ], carotenoids and phenolics (including flavonoids) [ 5 , 6 ]. In addition, our cells produce lipids endowed with biological activity in signal transduction, the best characterized being derivatives of poly-unsaturated fatty acids (PUFAs).…”

Section: Introductionmentioning

confidence: 99%

Deciphering Complex Interactions in Bioactive Lipid Signaling

Maccarrone

2023

Molecules

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Lipids are usually viewed as metabolic fuel and structural membrane components. Yet, in recent years, different families of lipids able to act as authentic messengers between cells and/or intracellularly have been discovered. Such lipid signals have been shown to exert their biological activity via specific receptors that, by triggering distinct signal transduction pathways, regulate manifold pathophysiological processes in our body. Here, endogenous bioactive lipids produced from arachidonic acid (AA) and other poly-unsaturated fatty acids will be presented, in order to put into better perspective the relevance of their mutual interactions for health and disease conditions. To this end, metabolism and signal transduction pathways of classical eicosanoids, endocannabinoids and specialized pro-resolving mediators will be described, and the intersections and commonalities of their metabolic enzymes and binding receptors will be discussed. Moreover, the interactions of AA-derived signals with other bioactive lipids such as shingosine-1-phosphate and steroid hormones will be addressed.

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Cannabinoids in neuroinflammatory disorders: Focusing on multiple sclerosis, Parkinsons, and Alzheimers diseases

Cited by 20 publications

References 208 publications

CBGA ameliorates inflammation and fibrosis in nephropathy

CBGA ameliorates inflammation and fibrosis in nephropathy

Neuroprotective effects of gemfibrozil in neurological disorders: Focus on inflammation and molecular mechanisms

Deciphering Complex Interactions in Bioactive Lipid Signaling

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