Cannabis Cue Reactivity and Craving Among Never, Infrequent and Heavy Cannabis Users

Henry, Erika A.; Kaye, Jesse T.; Bryan, Angela D.; Hutchison, Kent E.; Ito, Tiffany A.

doi:10.1038/npp.2013.324

Cited by 44 publications

(35 citation statements)

References 34 publications

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Section: Sex Differences In the Rewarding Properties Of Cannabinoidsmentioning

confidence: 99%

“…For example, prior work has shown that greater cannabis use in both women and men is associated with greater cannabis cue reactivity [124]. Women, compared to men, exhibited larger cue-induced enhancement of event related potential signals, specifically in P300 amplitude, shown to be enhanced in many studies of drug-related cue reactivity, and in early posterior negativity amplitude, shown to be sensitive to motivation-related stimuli [124]. In cannabis users exposed to subliminally presented cannabis cues, men had preferential BOLD signal response in left striatum and left lateral orbitofrontal cortex, yet women preferentially responded in striatum, left hippocampus and amygdala [125].…”

Section: Sex Differences In the Rewarding Properties Of Cannabinoidsmentioning

confidence: 99%

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Mechanisms Underlying Sex Differences in Cannabis Use

et al. 2017

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Purpose of the Review Cannabis is the most commonly used illicit substance worldwide. In recent decades, highly concentrated products have flooded the market, and prevalence rates have increased. Gender differences exist in cannabis use, as men have higher prevalence of both cannabis use and cannabis use disorder (CUD), while women progress more rapidly from first use to CUD. This paper reviews findings from preclinical and human studies examining the sex-specific neurobiological underpinnings of cannabis use and CUD, and associations with psychiatric symptoms. Recent Findings Sex differences exist in the endocannabinoid system, in cannabis exposure effects on brain structure and function, and in the co-occurrence of cannabis use with symptoms of anxiety, depression and schizophrenia. In female cannabis users, anxiety symptoms correlate with larger amygdala volume and social anxiety disorder symptoms correlate with CUD symptoms. Female cannabis users are reported to be especially vulnerable to earlier onset of schizophrenia, and mixed trends emerge in the correlation of depressive symptoms with cannabis exposure in females and males. Summary As prevalence of cannabis use may continue to increase given the shifting policy landscape regarding marijuana laws, understanding the neurobiological mechanisms of cannabis exposure in females and males is key. Examining these mechanisms may help inform future research on sex-specific pharmacological and behavioral interventions for women and men with high-risk cannabis use, comorbid psychiatric disease, and CUD.

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Section: Sex Differences In the Rewarding Properties Of Cannabinoidsmentioning

confidence: 99%

Section: Sex Differences In the Rewarding Properties Of Cannabinoidsmentioning

confidence: 99%

Mechanisms Underlying Sex Differences in Cannabis Use

et al. 2017

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“…For cannabis use as a cue for nicotine dependence, we only know that cannabis use is a predictor of nicotine dependence, according to the reverse gateway theory [37]. Indeed, studies with cannabis cue are very rare [38]. This study filled in the gap for substance use as a cue for polydrug dependence for the couple of substance alcohol/cannabis and tobacco/cannabis.…”

Section: Discussionmentioning

confidence: 92%

Simultaneous use of Alcohol, Tobacco and Cannabis in Relation to Severity of Substance Dependence: A Study among Young Swiss Men

Baggio¹

2014

J Addict Res Ther

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Objective: This study investigated patterns of the simultaneous use of alcohol, tobacco and cannabis among young polydrug users, and whether use of one substance might be a cue for use of another and associations with the severity of substance dependence. Methods:The study focused on 3 subsamples from the ongoing Swiss Cohort Study on Substance Use Risk Factors (C-SURF, N=5,990). It used 12 months of data on alcohol/tobacco co-users, alcohol/cannabis co-users and tobacco/cannabis co-users (N=2,660, 1,755 and 1,460 respectively. Simultaneous use, numbers of symptoms of substance dependence, and hazardous use of alcohol, tobacco and cannabis were assessed. The effect of simultaneous polydrug use (SPU) on the numbers of symptoms of substance dependence was tested using analysis of variance.Results: Polydrug use was most common as SPU, and less common as non/occasional SPU. Moreover, when participants started to use one substance while using another, the severity of substance dependence was more strongly associated with the triggered substance than with cue. Conclusions:This study highlights the necessity to take SPU into account. First, SPU rather than separate drug use was the most common pattern for polydrug users. Second, frequent SPU was associated with increased numbers of symptoms of substance dependence compared to non/occasional SPU. Furthermore, SPU may reveal the severity of substance use dependence, when substance use is triggered by a cue substance. For these reasons, SPU should be a serious cause for concern for prevention and intervention purposes.

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“…This effect has been especially observed in the addiction field in studies using oddball paradigms based on substancerelated cues (e.g. Henry et al, 2013;Sokhadze et al, 2008).…”

Section: Introductionmentioning

confidence: 90%

Electrophysiological correlates of alcohol- and non-alcohol-related stimuli processing in binge drinkers: A follow-up study

et al. 2014

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Background: The continuation of binge drinking is associated with the development of neurocognitive brain abnormalities similar to those observed in patients with alcohol dependence. Alcohol cue reactivity constitutes a risk marker for alcohol dependence. Through event-related potentials (ERPs), we aimed to examine its potential presence as well as its evolution over time in binge drinkers in a one-year period. Methods: ERPs were recorded during a visual oddball task in which controls (n=15) and binge drinkers (n=15) had to detect infrequent deviant stimuli (related or unrelated to alcohol) among frequent standard stimuli. The test was performed twice with a one-year interval in order to explore the longlasting influence of drinking habits. Results: Contrary to the controls, binge drinkers showed significantly reduced amplitudes of the P1 component for both alcohol and non-alcoholrelated cues and of the P3 component only for neutral cues in the second assessment compared with the first. Conclusion: The continuation of binge drinking over one year is associated with the development of brain functional abnormalities (indexed by the P1 component) as well as a higher reactivity to alcohol-related stimuli and/or a decreased reactivity to non-alcohol-related stimuli (indexed by the P3 component).

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Cannabis Cue Reactivity and Craving Among Never, Infrequent and Heavy Cannabis Users

Cited by 44 publications

References 34 publications

Mechanisms Underlying Sex Differences in Cannabis Use

Mechanisms Underlying Sex Differences in Cannabis Use

Simultaneous use of Alcohol, Tobacco and Cannabis in Relation to Severity of Substance Dependence: A Study among Young Swiss Men

Electrophysiological correlates of alcohol- and non-alcohol-related stimuli processing in binge drinkers: A follow-up study

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