Cannabis, esquizofrenia y cognición, aportes de la conectividad cerebral

Abstract

ResumenAbstract original adicciones vol. xx, nº x · 2020La falta de consenso sobre si el consumo de cannabis favorece la neurocognición en pacientes con diagnóstico de esquizofrenia consumidores de esta sustancia, más los problemas metodológicos encontion in these patients, techniques such as fMRI and EEG have found brain impairment. Furthermore, regarding schizophrenia-diagnosed patients who use cannabis, some studies have shown less deterioration among cognitive domains, which may apparently be related with one of its components (CBD). Measuring brain connectivity can be useful for clarifying neurophysiological mechanisms of cognition in marihuana-using schizophrenia patients. Cognitive decline is generalized in schizophrenia patients and is considered fundamental for disease physiopathology.

Neurociencias: la conectividad cerebral

“…Los estudios de conectividad funcional conciben la relación adherente a la activación temporal entre la actividad cerebral y las diversas zonas estructurales distribuidas por todo el cerebro, cuya dependencia busca trazar una línea de conectividad juntamente con las conexiones fasciculares directas (Díaz-Soto et al, 2020).…”

Shedding light on the role of CX3CR1 in the pathogenesis of schizophrenia

“…Although the causes of schizophrenia remain unclear, the heterogeneous nature of the condition implies the contribution of multiple aetiological factors. The reports have suggested that the development of this illness may result among others from genetics [8][9][10], altered brain connectivity [11][12][13][14][15], abnormalities in neurotransmission systems [16][17][18][19][20][21] and/or environmental factors, including childhood trauma [22,23], maternal stress [24] and infections during pregnancy [25][26][27], obstetric complications [28] as well as prenatal malnutrition [29]. The interplay between some of these factors, for example, gene-environment interactions [30][31][32][33] with an increased focus on epigenetic regulation [34][35][36], has been also proposed as the basis of this disorder.…”

O uso de Cannabis como fator de risco para o desenvolvimento/progressão de quadros de Esquizofrenia: Uma revisão de literatura

“…Existe ainda, a divisão dos sintomas positivos (alucinações, delírios, alterações da linguagem e agitação), os sintomas negativos (isolamento, anedonia, avolia e a perda do afeto) e os cognitivos. Uma vez que a cognição corresponde a um dos domínios prejudicados pelo uso do cannabis, tem-se uma das intersecções para a justificativa do uso como um possível fator de risco para o desenvolvimento de esquizofrenia, especialmente quando o uso acontece precocemente e em altas quantidades/concentrações (Díaz-Soto et al, 2020;Ortiz-Medina et al, 2018;APA, 2014).…”