Cannabis induced myocardial infarction underlying mechanism and the place of glycoprotein IIb/IIIa inhibitors in its management: Two illustrative cases of acute anterior myocardial infarction related to cannabis

Noamen, Aymen; Hajlaoui, Nadhem; Ghaderian, Mehdi; Haouala, Habib

doi:10.15761/jic.1000162

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Almost unanimously all the cases presented with typical ACS like pictures with chest pain, ECG changes and elevated cardiac bio markers. The most commonly affected artery was proximal LAD ( Table 3 ) [ 13 , 14 , 15 , 16 , 17 ]. Our review yielded only one case with triple vessel involvement [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Few scattered cases of SCAD have also been reported with the use of recreational drugs like cocaine [ 11 ], methamphetamine [ 12 ] and marijuana [ 13 , 14 , 15 , 16 , 17 ]. Marijuana has been implicated as causative in a wide spectrum of cardiac disorders which range from ACS, coronary spasm, myocarditis to arrhythmias [ 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Marijuana and Coronary Dissection: A Case Report and Review of Literature

Kariyanna¹,

Chandrakumar²,

Chowdhury³

et al. 2021

AJMCR

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Spontaneous coronary artery dissection (SCAD) is a cardiac emergency and an uncommon cause of acute coronary syndrome (ACS) with a higher predominance in younger women. It is a non-traumatic, non-atherosclerotic lesion found to be associated with pregnancy, inflammatory disorders, connective tissue diseases and substance abuse. Our patient was a young woman with a chronic marijuana smoking history who was found to have a NSTEMI. Initial angiogram showed triple vessel disease involving left anterior descending artery (LAD), left circumflex artery (LCX) and obtuse marginal artery (OM). A repeat angiogram notably showed spontaneous progression with dissection in all three vessels attributable to substance abuse. We present you this rare occurrence of triple vessel SCAD secondary to marijuana with a literature review and discussion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Marijuana and Coronary Dissection: A Case Report and Review of Literature

Kariyanna¹,

Chandrakumar²,

Chowdhury³

et al. 2021

AJMCR

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Pharmacognosy and Effects of Cannabinoids in the Vascular System

Mensah

Tabrizchi

Daneshtalab

2022

ACS Pharmacol. Transl. Sci.

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Understanding the pharmacodynamics of cannabinoids is an essential subject due to the recent increasing global acceptance of cannabis and its derivation for recreational and therapeutic purposes. Elucidating the interaction between cannabinoids and the vascular system is critical to exploring cannabinoids as a prospective therapeutic agent for treating vascular-associated clinical conditions. This review aims to examine the effect of cannabinoids on the vascular system and further discuss the fundamental pharmacological properties and mechanisms of action of cannabinoids in the vascular system. Data from literature revealed a substantial interaction between endocannabinoids, phytocannabinoids, and synthetic cannabinoids within the vasculature of both humans and animal models. However, the mechanisms and the ensuing functional response is blood vessels and species-dependent. The current understanding of classical cannabinoid receptor subtypes and the recently discovered atypical cannabinoid receptors and the development of new synthetic analogs have further enhanced the pharmacological characterization of the vascular cannabinoid receptors. Compelling evidence also suggest that cannabinoids represent a formidable therapeutic candidate for vascular-associated conditions. Nonetheless, explanations of the mechanisms underlining these processes are complex and paradoxical based on the heterogeneity of receptors and signaling pathways. Further insight from studies that uncover the mechanisms underlining the therapeutic effect of cannabinoids in the treatment of vascular-associated conditions is required to determine whether the known benefits of cannabinoids thus currently outweigh the known/unknown risks.

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Cannabis induced myocardial infarction underlying mechanism and the place of glycoprotein IIb/IIIa inhibitors in its management: Two illustrative cases of acute anterior myocardial infarction related to cannabis

Cited by 2 publications

References 11 publications

Marijuana and Coronary Dissection: A Case Report and Review of Literature

Marijuana and Coronary Dissection: A Case Report and Review of Literature

Pharmacognosy and Effects of Cannabinoids in the Vascular System

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