Cannabis sativa: A look at protozoa, helminths, insect vectors, and pests

Guerra, Rhanoica Oliveira; Neto, José Rodrigues do Carmo; Silva, Priscilla Elias Ferreira da; Borges, Yarlla Loyane Lira; Franco, Pablo Igor Ribeiro; Machado, Juliana Reis; Silva, Marcos

doi:10.1016/j.fitote.2023.105467

Cited by 6 publications

(3 citation statements)

References 146 publications

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“…Chinese culture indicates it for rheumatic pain, intestinal constipation, menstrual disorders, and malaria; in the ancient Egypt it was used as an antiinflammatory agent for the eyes; and in India, as a part of the mixture to suppress anxiety [ 16 ]. Moreover, it has been utilized in the treatment of a wide variety of other diseases including epilepsy, seizure disorders, depression, insomnia, pain, asthma, nausea, and diarrhea [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Cannabinoids have the ability to affect various types of infectious agents. When parasites were treated in vitro or in vivo with cannabinoids, it has been observed to inhibit the proliferation, growth, and invasion of these pathogens [ 17 ]. According to the etiologic agent causing the infectious and parasitic diseases, treatments administered together with cannabinoids can significantly interfere with the control of the parasitemia and the clinical outcome of the disease [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Anthelmintic Effect of Cannabidiol against Echinococcus granulosus sensu stricto

Albani,

Fuentes,

Ramírez

et al. 2024

TropicalMed

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Cystic echinococcosis is a global parasitic zoonosis caused by infection with the larval stage of Echinococcus granulosus sensu lato. Cystic echinococcosis affects more than 1 million people worldwide, causing important economic costs in terms of management and livestock associated losses. Albendazole is the main drug used in treating human cystic echinococcosis. In spite of this, its low aqueous solubility, poor absorption, and consequently erratic bioavailability are the cause of its chemotherapeutic failures. Based on the described problem, new treatment alternatives urgently need to be developed. The aim of the present research was to study the in vitro and in vivo efficacy of cannabidiol (CBD), the second most abundant component of the Cannabis sativa plant, was demonstrated against E. granulosus sensu stricto. CBD (50 µg/mL) caused a decrease in protoscoleces viability of 80 % after 24 h of treatment which was consistent with the observed tegumental alterations. Detachment of the germinal layer was observed in 50 ± 10% of cysts treated with 50 µg/mL of CBD during 24 h. In the clinical efficacy study, all treatments reduced the weight of cysts recovered from mice compared with the control group. However, this reduction was only significant with ABZ suspension and the CBD + ABZ combination. As we could observe by the SEM study, the co-administration of CBD with ABZ suspension caused greater ultrastructural alteration of the germinal layer in comparison with that provoked with the monotherapy. Further in vivo research will be conducted by changing the dose and frequency of CBD and CBD + ABZ treatments and new available CBD delivery systems will also be assayed to improve bioavailability in vivo.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anthelmintic Effect of Cannabidiol against Echinococcus granulosus sensu stricto

Albani,

Fuentes,

Ramírez

et al. 2024

TropicalMed

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“…From an agronomical point of view, industrial hemp is considered a low-input and lowimpact crop; it is capable of growing without pesticides and herbicides, as it is noticeably resistant to fungi, rodents, and many types of weeds. Moreover, its residues can be used in organic farming for the control of soilborne pathogens, as they act as natural pesticides, miticides, and repellants [6]. Furthermore, the hemp plant tolerates stress from heavy metals and other pollutants [7], and for this reason, this crop is successfully used to remove contaminants from the soil [8].…”

Section: Introductionmentioning

confidence: 99%

Impact of Chitosan-Based Foliar Application on the Phytochemical Content and the Antioxidant Activity in Hemp (Cannabis sativa L.) Inflorescences

Beleggia,

Iannucci,

Menga

et al. 2023

Plants

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In the present study, the phytochemical content and the antioxidant activity in the inflorescences of the monoecious hemp cultivar Codimono grown in southern Italy were assessed, and their elicitation was induced by foliar spray application of 50 mg/L and 250 mg/L of chitosan (CHT) at three different molecular weights (low, CHT L; medium, CHT M; high CHT H). The analysis of the phytochemical profile confirmed that cannabinoids were the most abundant class (54.2%), followed by flavonoids (40.3%), tocopherols (2.2%), phenolic acids (1.9%), and carotenoids (1.4%). Cannabinoids were represented almost exclusively by cannabidiol, whereas cannabigerol and Δ9-tetrahydrocannabinol were detected at very low levels (the latter was below the legal limit of 0.3%). The most abundant flavonoids were orientin and vitexin, whereas tocopherols were mainly represented by α-tocopherol. The antioxidant activity was found to be positively correlated with flavonoids and tocopherols. Statistical analysis revealed that the CHT treatments significantly affected the phytochemical content and the antioxidant activity of hemp inflorescences. Notably, a significant increase in the total phenolic content (from +36% to +69%), the α-tocopherol (from +45% to +75%) and β+γ-tocopherol (from +35% to +82%) contents, and the ABTS radical scavenging activity (from +12% to +28%) was induced by all the CHT treatments. In addition, treatments with CHT 50 solutions induced an increase in the total flavonoid content (from +12% to +27%), as well as in the vitexin (from +17% to +20%) and orientin (from +20% to +30%) contents. Treatment with CHT 50 L almost always resulted in the greatest increases. Overall, our findings indicated that CHT could be used as a low-cost and environmentally safe elicitor to improve the health benefits and the economic value of hemp inflorescences, thus promoting their employment in the food, pharmaceutical, nutraceutical, and cosmetic supply chains.

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Cannabinoids as cytotoxic agents and potential modulators of the human parasite Trichomonas vaginalis

De Freitas,

Midlej

2025

Biomedicine & Pharmacotherapy

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Cannabis sativa: A look at protozoa, helminths, insect vectors, and pests

Cited by 6 publications

References 146 publications

Anthelmintic Effect of Cannabidiol against Echinococcus granulosus sensu stricto

Anthelmintic Effect of Cannabidiol against Echinococcus granulosus sensu stricto

Impact of Chitosan-Based Foliar Application on the Phytochemical Content and the Antioxidant Activity in Hemp (Cannabis sativa L.) Inflorescences

Cannabinoids as cytotoxic agents and potential modulators of the human parasite Trichomonas vaginalis

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