Cannabis Use and Cognition in Adults Prescribed Opioids for Persistent Pain

Wildes, Megan; Bigand, Teresa; Layton, Matthew E.; Wilson, Marian

doi:10.1016/j.pmn.2019.06.014

Cited by 13 publications

(11 citation statements)

References 38 publications

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“…There is a growing interest in exploring the benefit of cannabisderived products for managing chronic persistent pain (Wallace et al, 2015). However, it has been shown in recent studies that cannabis products increase the risk of depression and anxiety in adults experiencing chronic pain (Wildes et al, 2020). Thus, individualizing the analgesic therapy (type and dose) based on the patient's profile is essential for preventing pain and pain-related cognitive decline.…”

Section: Therapies For Chronic Pain and Impact On Cognition Pharmacological Therapiesmentioning

confidence: 99%

Cognition and Pain: A Review

2021

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Cognition is defined as the brain’s ability to acquire, process, store, and retrieve information. Pain has been described as an unpleasant sensory or emotional experience, and for experiencing pain consciously, cognitive processing becomes imperative. Moreover, evaluation of pain strongly depends on cognition as it requires learning and recall of previous experiences. There could be a possible close link between neural systems involved in cognition and pain processing, and studies have reported an association between pain and cognitive impairment. In this narrative review, we explore the available evidence that has investigated cognitive changes associated with pain. We also examine the anatomical, biochemical, and molecular association of pain and neuro-cognition. Additionally, we focus on the cognitive impairment caused by analgesic medications. There is a need to improve our understanding of pathophysiology and cognitive impairment mechanisms associated with chronic pain and its treatment. This area provides a diverse opportunity for grounding future research, aiding institution of timely interventions to prevent chronic pain and associated cognitive decline, ultimately improving patient care.

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Section: Therapies For Chronic Pain and Impact On Cognition Pharmacological Therapiesmentioning

confidence: 99%

Cognition and Pain: A Review

2021

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“… 19 , 20 , 21 , 22 , 23 , 24 However, the effectiveness of cannabis substitution for opioids is not universally observed. 25 , 26 …”

Section: Introductionmentioning

confidence: 99%

“…In addition, it has been reported that patients commonly use medical cannabis as a substitute for opioid medication 19‐24 . However, the effectiveness of cannabis substitution for opioids is not universally observed 25,26 …”

Section: Introductionmentioning

confidence: 99%

Consensus‐based recommendations for titrating cannabinoids and tapering opioids for chronic pain control

Sihota

Smith

Ahmed³

et al. 2020

Int J Clin Pract

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“…These cognitive benefits were attributed to higher levels of CBD. In contrast, a recent study found that high CBD products may be linked with poorer cognitive function in adults using opioid medicine for chronic pain [15]. Emerging evidence also suggests that delta‐9‐tetrahydrocannabinol (THC), despite its known psychoactive properties, may reverse cognitive impairment in mice models when administered in low doses [16].…”

Section: Introductionmentioning

confidence: 99%

Medical cannabis and cognitive performance in middle to old adults treated for chronic pain

Sznitman

Vulfsons

Meiri

et al. 2020

Drug and Alcohol Review

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Introduction and Aims Cannabis exposure is becoming more common in older age but little is known about how it is associated with brain health in this population. This study assesses the relationship between long‐term medical cannabis (MC) use and cognitive function in a sample of middle‐aged and old chronic pain patients. Design and Methods A cross‐sectional study was conducted among chronic pain patients aged 50+ years who had MC licenses (n = 63) and a comparison group who did not have MC licenses (n = 62). CogState computerised brief battery was used to assess cognitive performance of psychomotor reaction, attention, working memory and new learning. Regression models and Bayesian t‐tests examined differences in cognitive performance in the two groups. Furthermore, the associations between MC use patterns (dosage, cannabinoid concentrations, length and frequency of use and hours since last use) with cognition were assessed among MC licensed patients. Results Mean age was 63 ± 6 and 60 ± 5 years in the non‐exposed and MC patients, respectively. Groups did not significantly differ in terms of cognitive performance measures. Furthermore, none of the MC use patterns were associated with cognitive performance. Discussion and Conclusions These results suggest that use of whole plant MC does not have a widespread impact on cognition in older chronic pain patients. Considering the increasing use of MC in older populations, this study could be a first step towards a better risk–benefit assessment of MC treatment in this population. Future studies are urgently needed to further clarify the implications of late‐life cannabis use for brain health.

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Cannabis Use and Cognition in Adults Prescribed Opioids for Persistent Pain

Cited by 13 publications

References 38 publications

Cognition and Pain: A Review

Cognition and Pain: A Review

Consensus‐based recommendations for titrating cannabinoids and tapering opioids for chronic pain control

Medical cannabis and cognitive performance in middle to old adults treated for chronic pain

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