Cannabis use disorder and adverse cardiovascular outcomes: A population‐based retrospective cohort analysis of adults from Alberta, Canada

Bahji, Anees; Hathaway, Josh; Adams, Denise; Crockford, David; Edelman, E. Jennifer; Stein, Michael D.; Patten, Scott B.

doi:10.1111/add.16337

Cited by 2 publications

(1 citation statement)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 Administrative diagnostic codes for illicit substance use disorders, including cannabis, have very high specificity (greater than 95%). [29][30][31][32][33] Other variables were included a priori based on prior work and clinical plausibility. These included factors such as age, sex, race/ethnicity (i.e., Black, Hispanic, White, and other [including Native Americans, Asians, and Pacific Islander due to sample size constraints]), primary payer, type of admission (i.e., elective and nonelective), and median household income based on zip code.…”

Section: Primary Exposures and Outcome Interestmentioning

confidence: 99%

Cannabis use disorder and perioperative outcomes following complex cancer surgery

Munir,

Woldesenbet,

Endo

et al. 2024

Journal of Surgical Oncology

View full text Add to dashboard Cite

IntroductionCannabis usage is increasing in the United States, especially among patients with cancer. We sought to evaluate whether cannabis use disorder (CUD) was associated with higher morbidity and mortality among patients undergoing complex cancer surgery.MethodsPatients who underwent complex cancer surgery between January 2016 and December 2019 were identified in the National Inpatient Sample database. CUD was defined according to ICD‐10 codes. Propensity score matching was performed to create a 1:1 matched cohort that was well balanced with respect to covariates, which included patient comorbidities, sociodemographic factors, and procedure type. The primary composite outcome was in‐hospital mortality and seven major perioperative complications (myocardial ischemia, acute kidney injury, stroke, respiratory failure, venous thromboembolism, hospital‐acquired infection, and surgical procedure‐related complications).ResultsAmong 15 014 patients who underwent a high‐risk surgical procedure, a cohort of 7507 patients with CUD (median age; 43 years [IQR: 30−56 years]; n = 3078 [41.0%] female) were matched with 7507 patients who were not cannabis users (median age; 44 years [IQR: 30−58 years); n = 2997 [39.9%] female). CUD was associated with slight increased risk relative to postoperative kidney injury (CUD, 7.8% vs. no CUD, 6.1%); however, in‐hospital mortality was slightly lower (CUD, 0.9% vs. no CUD, 1.6%) (both p < 0.001). On multivariable analysis, after controlling for other risk factors, CUD was not associated with higher morbidity and mortality (adjusted odds ratio: 1.06, 95% CI: 0.98−1.15; p = 0.158).ConclusionCUD was not associated with a higher risk of postoperative morbidity and mortality following complex cancer surgery.

show abstract

Section: Primary Exposures and Outcome Interestmentioning

confidence: 99%

Cannabis use disorder and perioperative outcomes following complex cancer surgery

Munir,

Woldesenbet,

Endo

et al. 2024

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

A Review of Cardiovascular Effects of Marijuana Use

Rezkalla,

Kloner

2024

Journal of Cardiopulmonary Rehabilitation and Prevention

View full text Add to dashboard Cite

Objective: Cannabinoids exert their effects on body tissues via cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors. Receptors are present in brain, myocardium, vascular endothelium, platelets, and adipose tissues. Under normal physiologic conditions, endocannabinoid effects are minimal. The use of exogenous cannabis leads to endothelial dysfunction and increases vascular thrombosis via CB1 receptor stimulation. On the other hand, CB2 receptors may have a beneficial anti-inflammatory response. Review Methods: We reviewed reports of the effects of cannabis on the cardiovascular system utilizing PUBMED from the last 20 years with emphasis on the most recent reports. Summary: Despite a plethora of reviews and some retrospective studies, there is a need for more definitive data regarding the effect of cannabis use on cardiovascular events (CVE). Marijuana does not appear to accelerate atherosclerosis. There is a suggestion that it may induce myocardial infarction in a small percentage of users, especially in male users, particularly during recent use. It has a possibility of increasing cerebrovascular events when combined with other risk factors such as tobacco use. There is an association between cannabis use and increased evidence of peripheral vascular disease. To have a definitive answer to the question of whether cannabis contributes to CVE, there is an urgent need for prospective controlled studies with patients presenting to academically oriented medical facilities with CVE following cannabis use for either medicinal or recreational use.

show abstract

Cannabis use disorder and adverse cardiovascular outcomes: A population‐based retrospective cohort analysis of adults from Alberta, Canada

Cited by 2 publications

References 75 publications

Cannabis use disorder and perioperative outcomes following complex cancer surgery

Cannabis use disorder and perioperative outcomes following complex cancer surgery

A Review of Cardiovascular Effects of Marijuana Use

Contact Info

Product

Resources

About