Cannabis Use Disorder: Friend or Foe in Septic Shock and Associated Mortality Among Geriatric Sepsis Patients With Chronic Kidney or Liver Disease?

Abstract

With the increasing medicinal use of cannabis and potential anti-inflammatory role, we aimed to assess the odds and in-hospital mortality of septic shock with vs. without cannabis use among geriatric sepsis patients with chronic kidney or liver diseases (CKD/CLD) using a nationally representative cohort. METHODS:We queried the National Inpatient Sample (2017) to identify geriatric sepsis patients with concomitant CKD/CLD complicated by septic shock. Primary outcomes (septic shock and associated inpatient mortality) and secondary outcomes (patient discharge and length of stay) were compared between cannabis users vs. non-users. Multivariable analysis was performed adjusting for confounders to assess the odds of septic shock and associated in-hospital mortality. A propensity score-matched analysis was performed to confirm outcomes observed in unmatched cohorts. A two-sided p-value<0.05 was considered statistically significant.

Cannabis Use and Its Multifaceted Impact on the Genitourinary System: A Scoping Review of the Literature

“…62 Dosage and frequency used were not provided. 62 Desai et al 63 researched cannabis use in geriatric patients with CKD and its association with septic shock and mortality. It was found that cannabis use, although frequency was not reported, did not affect the risk of developing septic shock but was associated with a significantly lower inpatient mortality rate.…”

“…It was found that cannabis use, although frequency was not reported, did not affect the risk of developing septic shock but was associated with a significantly lower inpatient mortality rate. 63 Surveys conducted by Collister et al 64 on Canadian adults with CKD and kidney failure found that smoking, consuming edibles, and oil treatments alleviated their symptoms, such as pain, sleep, and restless leg syndrome. Once again, the frequency of use of cannabis products was not reported in the study.…”