Cannabis Use in Fibromyalgia

Farré, Magı́; Farré, Adriana; Fiz, Jimena; Torrens, Marta

doi:10.1016/b978-0-12-800756-3.00112-5

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…(19,20) The endocannabinoid system is present in all of us, and its main actors are anandamide (AEA) and 2-arachidonoylglycerol (2-AG) (21), acting at the central and peripheral level via the cannabinoid receptors linked to proteins G: CB1R and CB2R and the proteins regulating their metabolism: monoacylglycerol lipase (MAGL) and fatty acid amidohydrolase (FAAH). (22) However, the existence of various peptides and arachidonic acid derivatives that also interact with CB1R and elicit effects similar to the endocannabinoids, has also been described. Currently an "expanded endocannabinoid system" is being discussed, which includes these mediators belonging to the same chemical class as endogenous cannabinoids, not metabolically linked to AEA or 2-AG and which act on other proteins different from CB1R and CB2R.…”

Section: Fibromyalgia the Cannabinoid System And Cannabismentioning

confidence: 99%

Efficacy of cannabinoids in fibromyalgia: a literature review

Anaya

Ortiz

Valencia

et al. 2021

Colomb. J. Anesthesiol.

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Fibromyalgia is a chronic disease of unclear etiology, involving a neural oversensitization and impaired pain modulation, in addition to a clinical deficiency of the endocannabinoid system. Fibromyalgia is associated with a number of somatic and psychological disorders and hence multiple pharmacological approaches have been used, including opioids, antidepressants, antiepileptics, and more recently medical cannabis. This narrative review comprises a review of the current literature on the efficacy of cannabinoids in fibromyalgia. The studies describe a possible influence of cannabis on pain control in patients with fibromyalgia, with positive effects on quality of life and sleep. The use of cannabis seems to be beneficial in patients with fibromyalgia; however, more robust studies are still needed to establish is actual efficacy in pain management, quality of life and improvement of associated symptoms.

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Section: Fibromyalgia the Cannabinoid System And Cannabismentioning

confidence: 99%

Efficacy of cannabinoids in fibromyalgia: a literature review

Anaya

Ortiz

Valencia

et al. 2021

Colomb. J. Anesthesiol.

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“…Besides THC, particular importance is also given to cannabidiol (CBD), which does not produce any psychedelic effects [ 16 ]. CBD is commonly used to treat various medical conditions in the human body [ 5 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. In addition to THC and CBD, several other cannabinoids have already been identified as having medicinal properties (e.g., tetrahydrocannabivarin (THCV), cannabichromene (CBC), cannabigerol (CBG), and cannabinol (CBN)) [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Cannabinoids in Oral Fluid Specimens as the Preferred Biological Matrix for a Point-of-Care Biosensor Diagnostic Device

Trif,

Harpaz,

Eltzov

et al. 2024

Biosensors

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An increasing number of countries have started to decriminalize or legalize the consumption of cannabis for recreational and medical purposes. The active ingredients in cannabis, termed cannabinoids, affect multiple functions in the human body, including coordination, motor skills, memory, response time to external stimuli, and even judgment. Cannabinoids are a unique class of terpeno-phenolic compounds, with 120 molecules discovered so far. There are certain situations when people under the influence of cannabis may be a risk to themselves or the public safety. Over the past two decades, there has been a growing research interest in detecting cannabinoids from various biological matrices. There is a need to develop a rapid, accurate, and reliable method of detecting cannabinoids in oral fluid as it can reveal the recent intake in comparison with urine specimens, which only show a history of consumption. Significant improvements are continuously made in the analytical formats of various technologies, mainly concerning improving their sensitivity, miniaturization, and making them more user-friendly. Additionally, sample collection and pretreatment have been extensively studied, and specific devices for collecting oral fluid specimens have been perfected to allow rapid and effective sample collection. This review presents the recent findings regarding the use of oral fluid specimens as the preferred biological matrix for cannabinoid detection in a point-of-care biosensor diagnostic device. A critical review is presented, discussing the findings from a collection of review and research articles, as well as publicly available data from companies that manufacture oral fluid screening devices. Firstly, the various conventional methods used to detect cannabinoids in biological matrices are presented. Secondly, the detection of cannabinoids using point-of-care biosensors is discussed, emphasizing oral fluid specimens. This review presents the current pressing technological challenges and highlights the gaps where new technological solutions can be implemented.

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Cannabis Use in Fibromyalgia

Cited by 2 publications

References 33 publications

Efficacy of cannabinoids in fibromyalgia: a literature review

Efficacy of cannabinoids in fibromyalgia: a literature review

Detection of Cannabinoids in Oral Fluid Specimens as the Preferred Biological Matrix for a Point-of-Care Biosensor Diagnostic Device

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